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Zebrafish fgf10b has a Complementary Function to fgf10a in Liver and Pancreas Development

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Abstract

Fgf10 is a critical growth factor in mammals for development of endodermal organs such as the liver, pancreas, lung, and gut. Due to whole genome duplication, the zebrafish has two fgf10 orthologs, fgf10a and fgf10b. While fgf10a has a role in development of the esophagus and swimbladder, we found in the present study that fgf10b had a complementary expression pattern in the liver, pancreas, and gut. Morpholino knockdown of Fgf10b further confirmed its essential role in the normal development of liver and pancreas. Thus, our data provide another example of functional partition of two duplicated othologous genes during evolution.

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Acknowledgments

This work was supported by the National Medical Research Council, Singapore. YC is supported by a graduate scholarship from the National University of Singapore Graduate School for Integrative Sciences and Engineering and WZ is supported by a graduate scholarship from the National University of Singapore.

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Authors and Affiliations

  1. Department of Biological Sciences, National University of Singapore, Singapore, Singapore

    Chuan Yan, Weiling Zheng & Zhiyuan Gong

  2. National University of Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore

    Chuan Yan & Zhiyuan Gong

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  1. Chuan Yan
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  2. Weiling Zheng
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  3. Zhiyuan Gong
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Correspondence to Zhiyuan Gong.

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Chuan Yan and Weiling Zheng authors contributed equally

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Yan, C., Zheng, W. & Gong, Z. Zebrafish fgf10b has a Complementary Function to fgf10a in Liver and Pancreas Development. Mar Biotechnol 17, 162–167 (2015). https://doi.org/10.1007/s10126-014-9604-x

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  • DOI: https://doi.org/10.1007/s10126-014-9604-x

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