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Microarray Analysis of Hepatic Gene Expression in Juvenile Japanese Flounder Paralichthys olivaceus Fed Diets Supplemented with Fish or Vegetable Oils

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Abstract

Gene expression profiling was performed in Japanese flounder Paralichthys olivaceus fed diets supplemented with fish oil (FO), linseed oil (LO), or olive oil (OO) for 6 weeks. The LO and OO groups showed significantly retarded growth, lower feed intake, lower protein efficiency ratio, and lower hepatosomatic index (P < 0.05). Liver fatty acid composition reflected the dietary fatty acid composition. Microarray analysis revealed that dietary n − 3 highly unsaturated fatty acid (HUFA) deficiency affected 169 transcripts. In the LO group, 57 genes were up-regulated and 38 genes were down-regulated, whereas in the OO group nine genes were up-regulated and 87 genes were down-regulated. Analysis of the functional annotations suggested that dietary n − 3 HUFA affected genes involved in signal transduction (23.2 %), cellular processes (21.1 %), metabolism (including glucose, lipid, and nucleobase; 15.5 %), transport (11.3 %), regulation of transcription (10.5 %), and immune response (4.2 %). Several genes encoding serine/threonine kinases such as protein kinase C and calmodulin-dependent kinase and nuclear hormone receptors such as vitamin D receptor, retinoic acid receptor, and receptors for cytokines (bone morphogenic protein and transforming growth factor β) were affected. Among 169 transcripts, 22 genes were affected in both LO and OO groups. The present study identified several genes involved in n − 3 HUFA deficiency-sensitive pathways, which will be useful for selective breeding of flounder strains able to adapt to n − 3 HUFA deficiency.

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Acknowledgments

The expenses of this study were partially defrayed by a grant to Y.H. from JSPS-NRCT Asian Core University Program “Development of new bio-technology for aquaculture and risk management of aquaculture products”. U.L. is supported by a scholarship from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

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  1. Department of Marine Bioscience, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan, Minato 4-5-7, Tokyo, 108-8477, Japan

    Ubonrat Limtipsuntorn, Yutaka Haga, Hidehiro Kondo, Ikuo Hirono & Shuichi Satoh

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  1. Ubonrat Limtipsuntorn
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  2. Yutaka Haga
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Limtipsuntorn, U., Haga, Y., Kondo, H. et al. Microarray Analysis of Hepatic Gene Expression in Juvenile Japanese Flounder Paralichthys olivaceus Fed Diets Supplemented with Fish or Vegetable Oils. Mar Biotechnol 16, 88–102 (2014). https://doi.org/10.1007/s10126-013-9535-y

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