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Identification of Harman as the Antibiotic Compound Produced by a Tunicate-Associated Bacterium

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Abstract

The alkaloid harman, previously reported from some marine invertebrates, was identified as the antibiotic substance of the tunicate-associated bacterium Enterococcus faecium. It exhibited antibacterial activity (MIC, 0.017 mM) against the ichthyopathogenic strain Vibrio anguillarum.

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Acknowledgements

We thank F. Monniot for identification of the tunicate; J.P. Brouard and N. Morin for low and high resolution mass spectra, respectively; G. Gastine for antibacterial tests; and J.L. Nicolas (Ifremer, Brest) for providing Vibrio strains. This work was supported by the International Foundation of Science (IFS) with grant N:F 2401-2 to A.F.

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Authors and Affiliations

  1. Laboratoire de Biochimie Marine, Département de Biologie, Faculté des Sciences, Université Chouaib Doukkali, BP 20 El Jadida, Morocco

    H. Aassila, S. Rifai & A. Fassouane

  2. Laboratoire de Chimie, associé au CNRS, Muséum National d'Histoire Naturelle, 63 rue Buffon, 75005 Paris, France

    M. L. Bourguet-Kondracki & M. Guyot

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  1. H. Aassila
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  2. M. L. Bourguet-Kondracki
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  3. S. Rifai
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  4. A. Fassouane
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  5. M. Guyot
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Correspondence to M. Guyot.

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Aassila, H., Bourguet-Kondracki, M., Rifai, S. et al. Identification of Harman as the Antibiotic Compound Produced by a Tunicate-Associated Bacterium . Mar. Biotechnol. 5, 163–166 (2003). https://doi.org/10.1007/s10126-002-0060-7

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  • DOI: https://doi.org/10.1007/s10126-002-0060-7

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