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Isolation of Haliclonamides: New Peptides as Antifouling Substances from a Marine Sponge Species, Haliclona

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Abstract

Bioassay-guided fractionation of an extract of a marine sponge species, Haliclona, led to the isolation and identification of new peptides, Haliclonamides C, D, and E. Their structures were determined by spectroscopic methods. These compounds showed repellent activity against the blue mussel Mytilus edulis galloprovincialis.

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Authors and Affiliations

  1. Marine Biotechnology Institute, Shimizu Laboratories, 1900 Sodeshi-cho, Shimizu-shi, 424-0037, Shizuoka, Japan

    Yutaka Sera, Kyoko Adachi & Yoshikazu Shizuri

  2. Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya-shi, 468-8503, Aichi, Japan

    Kiyonaga Fujii

Authors
  1. Yutaka Sera
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  2. Kyoko Adachi
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  3. Kiyonaga Fujii
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  4. Yoshikazu Shizuri
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Sera, Y., Adachi, K., Fujii, K. et al. Isolation of Haliclonamides: New Peptides as Antifouling Substances from a Marine Sponge Species, Haliclona. Mar. Biotechnol. 4, 441–446 (2002). https://doi.org/10.1007/s10126-001-0082-6

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  • DOI: https://doi.org/10.1007/s10126-001-0082-6

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