Skip to main content
SpringerLink
Log in

Recent progress in exploiting small molecule peptides as supramolecular hydrogelators

  • Review
  • Published:
Chinese Journal of Polymer Science Aims and scope Submit manuscript

Abstract

Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their inherent biodegradability and biocompatibility, as well as versatility in molecular design and ease of synthesis. Built upon the directional, intermolecular interactions such as hydrogen bonding and π-π stacking, peptide-based molecular units can associate in aqueous solution into filamentous assemblies of various sizes and shapes. Under appropriate conditions, these filamentous assemblies can percolate into a 3D network with materials properties tailorable for specific biomedical applications. In this review, we survey the literature published over the past three years in the development of peptide-based hydrogelators for biomedical applications. We highlight several representative examples and center our discussion on the fundamentals of molecular design, assembly, and gelation conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Appel, E.A., del Barrio, J., Loh, X.J. and Scherman, O.A., Chem. Soc. Rev., 2012, 41(18): 6195

    Article  CAS  Google Scholar 

  2. Du, X.W., Zhou, J., Shi, J.F. and Xu, B., Chem. Rev., 2015, 115(24): 13165

    Article  CAS  Google Scholar 

  3. Hoffman, A.S., Adv. Drug Deliver. Rev., 2012, 64: 18

    Article  Google Scholar 

  4. Lau, H.K. and Kiick, K.L., Biomacromolecules, 2015, 16(1): 28

    Article  CAS  Google Scholar 

  5. Eslahi, N., Abdorahim, M. and Simchi, A., Biomacromolecules, 2016, 17(11): 3441

    Article  CAS  Google Scholar 

  6. Drury, J.L. and Mooney, D.J., Biomaterials, 2003, 24(24): 4337

    Article  CAS  Google Scholar 

  7. Lee, K.Y. and Mooney, D.J., Chem. Rev., 2001, 101(7): 1869

    Article  CAS  Google Scholar 

  8. Jabbari, E., Leijten, J., Xu, Q.B. and Khademhosseini, A., Mater. Today, 2016, 19(4): 190

    Article  CAS  Google Scholar 

  9. Vega, S.L., Kwon, M.Y. and Burdick, J.A., Eur. Cells. Mater., 2017, 33: 59

    Article  CAS  Google Scholar 

  10. Annabi, N., Tamayol, A., Uquillas, J.A., Akbari, M., Bertassoni, L.E., Cha, C., Camci-Unal, G., Dokmeci, M.R., Peppas, N.A. and Khademhosseini, A., Adv. Mater., 2014, 26(1): 85

    Article  CAS  Google Scholar 

  11. Holmes, R.A., Yang, X., Tronci, G. and Wood, D., Tissue Eng. Pt. A, 2016, 22: S126

    Google Scholar 

  12. Slaughter, B.V., Khurshid, S.S., Fisher, O.Z., Khademhosseini, A. and Peppas, N.A., Adv. Mater., 2009, 21(32-33): 3307

    Article  CAS  Google Scholar 

  13. Yang, J.A., Yeom, J., Hwang, B.W., Hoffman, A.S. and Hahn, S.K., Prog. Polym. Sci., 2014, 39(12): 1973

    Article  CAS  Google Scholar 

  14. Singh, A. and Peppas, N.A., Adv. Mater., 2014, 26(38): 6530

    Article  CAS  Google Scholar 

  15. Wen, Y., Waltman, A., Han, H.F. and Collier, J.H., ACS Nano, 2016, 10(10): 9274

    Article  CAS  Google Scholar 

  16. Rudra, J.S., Sun, T., Bird, K.C., Daniels, M.D., Gasiorowski, J.Z., Chong, A.S. and Collier, J.H., ACS Nano, 2012, 6(2): 1557

    Article  CAS  Google Scholar 

  17. Barrett, J.C., Ulery, B.D., Trent, A., Liang, S., David, N.A. and Tirrell, M.V., ACS. Biomater. Sci. Eng., 2017, 3(2): 144

    Article  CAS  Google Scholar 

  18. Vashist, A., Vashist, A., Gupta, Y.K. and Ahmad, S., J. Mater. Chem. B, 2014, 2(2): 147

    Article  CAS  Google Scholar 

  19. Hoare, T.R. and Kohane, D.S., Polymer, 2008, 49(8): 1993

    Article  CAS  Google Scholar 

  20. Ashley, G.W., Henise, J., Reid, R. and Santi, D.V., Proc. Natl. Acad. Sci. U.S.A., 2013, 110(6): 2318

    Article  CAS  Google Scholar 

  21. Singh, N.K. and Lee, D.S., J. Control. Release, 2014, 193: 214

    Article  CAS  Google Scholar 

  22. Zhang, Y.F., Wang, R., Hua, Y.Y., Baumgartner, R. and Cheng, J.J., ACS Macro Lett., 2014, 3(7): 693

    Article  CAS  Google Scholar 

  23. Purcell, B.P., Lobb, D., Charati, M.B., Dorsey, S.M., Wade, R.J., Zellars, K.N., Doviak, H., Pettaway, S., Logdon, C.B., Shuman, J.A., Freels, P.D., Gorman, J.H., Gorman, R.C., Spinale, F.G. and Burdick, J.A., Nat. Mater., 2014, 13(6): 653

    Article  CAS  Google Scholar 

  24. Hartlieb, M., Kempe, K. and Schubert, U.S., J. Mater. Chem. B, 2015, 3(4): 526

    Article  CAS  Google Scholar 

  25. Nguyen, Q.V., Huynh, D.P., Park, J.H. and Lee, D.S., Eur. Polym. J., 2015, 72: 602

    Article  CAS  Google Scholar 

  26. Wu, X.L., He, C.L., Wu, Y.D., Chen, X.S. and Cheng, J.J., Adv. Funct. Mater., 2015, 25(43): 6744

    Article  CAS  Google Scholar 

  27. Fu, X.H., Shen, Y., Ma, Y.A., Fu, W.X. and Li, Z.B., Sci. China-Chem., 2015, 58(6): 1005

    Article  CAS  Google Scholar 

  28. Ma, Y.N., Fu, X.H., Shen, Y., Fu, W.X. and Li, Z.B., Macromolecules, 2014, 47(14): 4684

    Article  CAS  Google Scholar 

  29. Zhang, S.S., Fu, W.X. and Li, Z.B., Polym. Chem., 2014, 5(10): 3346

    Article  CAS  Google Scholar 

  30. Srivastava, S., Andreev, M., Levi, A.E., Goldfeld, D.J., Mao, J., Heller, W.T., Prabhu, V.M., de Pablo, J.J. and Tirrell, M.V., Nat. Commun., 2017, 8: 14131

    Article  CAS  Google Scholar 

  31. Whittaker, J., Balu, R., Choudhury, N.R. and Dutta, N.K., Polym. Int., 2014, 63(9): 1545

    Article  CAS  Google Scholar 

  32. Zhao, Y., Nakajima, T., Yang, J.J., Kurokawa, T., Liu, J., Lu, J., Mizumoto, S., Sugahara, K., Kitamura, N., Yasuda, K., Daniels, A.U.D. and Gong, J.P., Adv. Mater., 2014, 26(3): 436

    Article  CAS  Google Scholar 

  33. Li, J., Mo, L.T., Lu, C.H., Fu, T., Yang, H.H. and Tan, W.H., Chem. Soc. Rev., 2016, 45(5): 1410

    Article  CAS  Google Scholar 

  34. Um, S.H., Lee, J.B., Park, N., Kwon, S.Y., Umbach, C.C. and Luo, D., Nat. Mater., 2006, 5(10): 797

    Article  CAS  Google Scholar 

  35. Xiong, X.L., Wu, C.C., Zhou, C.S., Zhu, G.Z., Chen, Z. and Tan, W.H., Macromol. Rapid Commun., 2013, 34(16): 1271

    Article  CAS  Google Scholar 

  36. Kahn, J.S., Hu, Y.W. and Willner, I., Accounts Chem. Res., 2017, 50(4): 680

    Article  CAS  Google Scholar 

  37. Singh, N., Kumar, M., Miravet, J.F., Ulijn, R.V. and Escuder, B., Chem. Eur. J., 2017, 23(5): 981

    Article  CAS  Google Scholar 

  38. Cui, H., Webber, M.J. and Stupp, S.I., Biopolymers, 2010, 94(1): 1

    Article  CAS  Google Scholar 

  39. Zhou, J., Li, J., Du, X.W. and Xu, B., Biomaterials, 2017, 129: 1

    Article  CAS  Google Scholar 

  40. Jonker, A.M., Lowik, D.W.P.M. and van Hest, J.C.M., Chem. Mater., 2012, 24(5): 759

    Article  CAS  Google Scholar 

  41. Sathaye, S., Mbi, A., Sonmez, C., Chen, Y.C., Blair, D.L., Schneider, J.P. and Pochan, D.J., Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2015, 7(1): 34

    Article  CAS  Google Scholar 

  42. Altunbas, A. and Pochan, D.J., Top. Curr. Chem., 2012, 310: 135

    Article  CAS  Google Scholar 

  43. Li, I.C., Moore, A.N. and Hartgerink, J.D., Biomacromolecules, 2016, 17(6): 2087

    Article  CAS  Google Scholar 

  44. Suh, J.K.F. and Matthew, H.W.T., Biomaterials, 2000, 21(24): 2589

    Article  CAS  Google Scholar 

  45. van Vlierberghe, S., Dubruel, P. and Schacht, E., Biomacromolecules, 2011, 12(5): 1387

    Article  CAS  Google Scholar 

  46. Shen, X.P., Shamshina, J.L., Berton, P., Gurau, G. and Rogers, R.D., Green. Chem., 2016, 18(1): 53

    Article  Google Scholar 

  47. Zhang, X.L., Dong, C.M., Huang, W.Y., Wang, H.M., Wang, L., Ding, D., Zhou, H., Long, J.F., Wang, T.L. and Yang, Z.M., Nanoscale, 2015, 7(40): 16666

    Article  CAS  Google Scholar 

  48. Patenaude, M., Smeets, N.M.B. and Hoare, T., Macromol. Rapid Commun., 2014, 35(6): 598

    Article  CAS  Google Scholar 

  49. Hennink, W.E. and van Nostrum, C.F., Adv. Drug Deliver. Rev., 2012, 64: 223

    Article  Google Scholar 

  50. Konieczynska, M.D. and Grinstaff, M.W., Accounts Chem. Res., 2017, 50(2): 151

    Article  CAS  Google Scholar 

  51. Holloway, J.L., Ma, H., Rai, R., Hankenson, K.D. and Burdick, J.A., Macromol. Biosci., 2015, 15(9): 1218

    Article  CAS  Google Scholar 

  52. Khetan, S., Guvendiren, M., Legant, W.R., Cohen, D.M., Chen, C.S. and Burdick, J.A., Nat. Mater., 2013, 12(5): 458

    Article  CAS  Google Scholar 

  53. Rodell, C.B., Wade, R.J., Purcell, B.P., Dusaj, N.N. and Burdick, J.A., ACS. Biomater. Sci. Eng., 2015, 1(4): 277

    Article  CAS  Google Scholar 

  54. Wade, R.J., Bassin, E.J., Rodell, C.B. and Burdick, J.A., Nat. Commun., 2015, 6: 6639

    Article  CAS  Google Scholar 

  55. Kloxin, A.M., Kasko, A.M., Salinas, C.N. and Anseth, K.S., Science, 2009, 324(5923): 59

    Article  CAS  Google Scholar 

  56. Brown, T.E., Marozas, I.A. and Anseth, K.S., Adv. Mater., 2017, 29(11): 1605001

    Article  CAS  Google Scholar 

  57. Grim, J.C., Marozas, I.A. and Anseth, K.S., J. Control. Release, 2015, 219: 95

    Article  CAS  Google Scholar 

  58. McKinnon, D.D., Brown, T.E., Kyburz, K.A., Kiyotake, E. and Anseth, K.S., Biomacromolecules, 2014, 15(7): 2808

    Article  CAS  Google Scholar 

  59. Rosales, A.M. and Anseth, K.S., Nat. Rev. Mater., 2016, 1(2): 15012

    Article  CAS  Google Scholar 

  60. Sridhar, B.V., Brock, J.L., Silver, J.S., Leight, J.L., Randolph, M.A. and Anseth, K.S., Adv. Healthc. Mater., 2015, 4(5): 702

    Article  CAS  Google Scholar 

  61. Webber, M.J., Appel, E.A., Meijer, E.W. and Langer, R., Nat. Mater., 2016, 15(1): 13

    Article  CAS  Google Scholar 

  62. Sun, J.E.P., Stewart, B., Litan, A., Lee, S.J., Schneider, J.P., Langhans, S.A. and Pochan, D.J., Biomater. Sci., 2016, 4(5): 839

    Article  CAS  Google Scholar 

  63. Dong, R.J., Pang, Y., Su, Y. and Zhu, X.Y., Biomater. Sci., 2015, 3(7): 937

    Article  CAS  Google Scholar 

  64. Zhao, F., Ma, M.L. and Xu, B., Chem. Soc. Rev., 2009, 38(4): 883

    Article  CAS  Google Scholar 

  65. Aida, T., Meijer, E.W. and Stupp, S.I., Science, 2012, 335(6070): 813

    Article  CAS  Google Scholar 

  66. Voorhaar, L. and Hoogenboom, R., Chem. Soc. Rev., 2016, 45(14): 4013

    Article  CAS  Google Scholar 

  67. Seiffert, S. and Sprakel, J., Chem. Soc. Rev., 2012, 41(2): 909

    Article  CAS  Google Scholar 

  68. Rodell, C.B., Kaminski, A.L. and Burdick, J.A., Biomacromolecules, 2013, 14(11): 4125

    Article  CAS  Google Scholar 

  69. Kakuta, T., Takashima, Y., Nakahata, M., Otsubo, M., Yamaguchi, H. and Harada, A., Adv. Mater., 2013, 25(20): 2849

    Article  CAS  Google Scholar 

  70. Yang, Z.M., Gu, H.W., Fu, D.G., Gao, P., Lam, J.K. and Xu, B., Adv. Mater., 2004, 16(16): 1440

    Article  CAS  Google Scholar 

  71. Appel, E.A., Tibbitt, M.W., Webber, M.J., Mattix, B.A., Veiseh, O. and Langer, R., Nat. Commun., 2015, 6: 7295

    Article  CAS  Google Scholar 

  72. Lock, L.L., Li, Y., Mao, X., Chen, H., Staedtke, V., Bai, R., Ma, W., Lin, R., Li, Y., Liu, G. and Cui, H., ACS Nano, 2017, 11(1): 797

    Article  CAS  Google Scholar 

  73. Hu, Y., Lin, R., Patel, K., Cheetham, A.G., Kan, C. and Cui, H., Coordin. Chem. Rev., 2016, 320: 2

    Article  CAS  Google Scholar 

  74. Wang, Z., Li, Y.W., Huang, Y.R., Thompson, M.P., LeGuyader, C.L.M., Sahu, S. and Gianneschi, N.C., Chem. Commun., 2015, 51(96): 17108

    Article  CAS  Google Scholar 

  75. Anderson, C.F. and Cui, H., Ind. Eng. Chem. Res., 2017, 56(20): 5761

    Article  CAS  Google Scholar 

  76. Lin, Y.A., Ou, Y.C., Cheetham, A.G. and Cui, H., ACS Macro Lett., 2013, 2(12): 1088

    Article  CAS  Google Scholar 

  77. Lin, Y.A., Ou, Y.C., Cheetham, A.G. and Cui, H., Biomacromolecules, 2014, 15(4): 1419

    Article  CAS  Google Scholar 

  78. Lock, L.L., Reyes, C.D., Zhang, P. and Cui, H., J. Am. Chem. Soc., 2016, 138(10): 3533

    Article  CAS  Google Scholar 

  79. Zhang, P.C., Cheetham, A.G., Lin, Y.A. and Cui, H., ACS Nano, 2013, 7(7): 5965

    Article  CAS  Google Scholar 

  80. Carter, J.M., Qian, Y., Foster, J.C. and Matson, J.B., Chem. Commun., 2015, 51(66): 13131

    Article  CAS  Google Scholar 

  81. Mart, R.J., Osborne, R.D., Stevens, M.M. and Ulijn, R.V., Soft Matter, 2006, 2(10): 822

    Article  CAS  Google Scholar 

  82. Wong, S., Shim, M.S. and Kwon, Y.J., J. Mater. Chem. B, 2014, 2(6): 595

    Article  CAS  Google Scholar 

  83. Choe, S., Bond, C.W., Harrington, D.A., Stupp, S.I., McVary, K.T. and Podlasek, C.A., Nanomed. Nanotechnol. Biol. Med., 2017, 13(1): 95

    Article  CAS  Google Scholar 

  84. Fichman, G. and Gazit, E., Acta Biomater., 2014, 10(4): 1671

    Article  CAS  Google Scholar 

  85. Yu, Z.Q., Xu, Q., Dong, C.B., Lee, S.S., Gao, L.Q., Li, Y.W., D'Ortenzio, M. and Wu, J., Curr. Pharm. Design., 2015, 21(29): 4342

    Article  CAS  Google Scholar 

  86. Qian, Y. and Matson, J.B., Adv. Drug Deliver. Rev., 2017, 110-111: 137

    Article  CAS  Google Scholar 

  87. Worthington, P., Langhans, S. and Pochan, D., Adv. Drug Deliver. Rev., 2017, 110-111: 127

    Article  CAS  Google Scholar 

  88. Moore, A.N. and Hartgerink, J.D., Accounts Chem. Res., 2017, 50(4): 714

    Article  CAS  Google Scholar 

  89. Berns, E.J., Sur, S., Pan, L.L., Goldberger, J.E., Suresh, S., Zhang, S.M., Kessler, J.A. and Stupp, S.I., Biomaterials, 2014, 35(1): 185

    Article  CAS  Google Scholar 

  90. Choe, S., Veliceasa, D., Bond, C.W., Harrington, D.A., Stupp, S.I., McVary, K.T. and Podlasek, C.A., Acta Biomater., 2016, 32: 89

    Article  CAS  Google Scholar 

  91. Acar, H., Srivastava, S., Chung, E.J., Schnorenberg, M.R., Barrett, J.C., LaBelle, J.L. and Tirrell, M., Adv. Drug Deliver. Rev., 2017, 110-111: 65

    Article  CAS  Google Scholar 

  92. Fleming, S. and Ulijn, R.V., Chem. Soc. Rev., 2014, 43(23): 8150

    Article  CAS  Google Scholar 

  93. Raeburn, J. and Adams, D.J., Chem. Commun., 2015, 51(25): 5170

    Article  CAS  Google Scholar 

  94. Su, H., Koo, J.M. and Cui, H., J. Control. Release, 2015, 219: 383

    Article  CAS  Google Scholar 

  95. Wang, Y., Cheetham, A.G., Angacian, G., Su, H., Xie, L. and Cui, H., Adv. Drug Deliver. Rev., 2017, 110-111: 112

    Article  CAS  Google Scholar 

  96. Chakroun, R.W., Zhang, P., Lin, R., Schiapparelli, P., Quinones-Hinojosa, A. and Cui, H., Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2017, DOI: 10.1002/wnan.1479

    Google Scholar 

  97. Lock, L.L., LaComb, M., Schwarz, K., Cheetham, A.G., Lin, Y.A., Zhang, P. and Cui, H., Faraday Discuss., 2013, 166: 285

    Article  CAS  Google Scholar 

  98. Lin, R., Zhang, P., Cheetham, A.G., Walston, J., Abadir, P. and Cui, H., Bioconjug. Chem., 2015, 26(1): 71

    Article  CAS  Google Scholar 

  99. Lock, L.L., Tang, Z., Keith, D., Reyes, C. and Cui, H., ACS Macro Lett., 2015, 4(5): 552

    Article  CAS  Google Scholar 

  100. Zhang, P., Lock, L.L., Cheetham, A.G. and Cui, H., Mol. Pharm., 2014, 11(3): 964

    Article  CAS  Google Scholar 

  101. Lampel, A., McPhee, S.A., Park, H.A., Scott, G.G., Humagain, S., Hekstra, D.R., Yoo, B., Frederix, P., Li, T.D., Abzalimov, R.R., Greenbaum, S.G., Tuttle, T., Hu, C., Bettinger, C.J. and Ulijn, R.V., Science, 2017, 356(6342): 1064

    Article  CAS  Google Scholar 

  102. Hauser, C.A.E. and Zhang, S.G., Chem. Soc. Rev., 2010, 39(8): 2780

    Article  CAS  Google Scholar 

  103. Zhao, X.B., Pan, F., Xu, H., Yaseen, M., Shan, H.H., Hauser, C.A.E., Zhang, S.G. and Lu, J.R., Chem. Soc. Rev., 2010, 39(9): 3480

    Article  CAS  Google Scholar 

  104. Holmes, T.C., de Lacalle, S., Su, X., Liu, G.S., Rich, A. and Zhang, S.G., Proc. Natl. Acad. Sci. U.S.A., 2000, 97(12): 6728

    Article  CAS  Google Scholar 

  105. Nagai, Y., Unsworth, L.D., Koutsopoulos, S. and Zhang, S.G., J. Control. Release, 2006, 115(1): 18

    Article  CAS  Google Scholar 

  106. Koutsopoulos, S., Unsworth, L.D., Nagai, Y. and Zhang, S.G., Proc. Natl. Acad. Sci. U.S.A., 2009, 106(12): 4623

    Article  CAS  Google Scholar 

  107. Koutsopoulos, S. and Zhang, S.G., J. Control. Release, 2012, 160(3): 451

    Article  CAS  Google Scholar 

  108. Altunbas, A., Lee, S.J., Rajasekaran, S.A., Schneider, J.P. and Pochan, D.J., Biomaterials, 2011, 32(25): 5906

    Article  CAS  Google Scholar 

  109. Branco, M.C., Pochan, D.J., Wagner, N.J. and Schneider, J.P., Biomaterials, 2009, 30(7): 1339

    Article  CAS  Google Scholar 

  110. Haines-Butterick, L., Rajagopal, K., Branco, M., Salick, D., Rughani, R., Pilarz, M., Lamm, M.S., Pochan, D.J. and Schneider, J.P., Proc. Natl. Acad. Sci. U.S.A., 2007, 104(19): 7791

    Article  CAS  Google Scholar 

  111. Rughani, R.V., Branco, M.C., Pochan, D. and Schneider, J.P., Macromolecules, 2010, 43(19): 7924

    Article  CAS  Google Scholar 

  112. Bakota, E.L., Wang, Y., Danesh, F.R. and Hartgerink, J.D., Biomacromolecules, 2011, 12(5): 1651

    Article  CAS  Google Scholar 

  113. Fallas, J.A., O'Leary, L.E.R. and Hartgerink, J.D., Chem. Soc. Rev., 2010, 39(9): 3510

    Article  CAS  Google Scholar 

  114. O'Leary, L.E.R., Fallas, J.A., Bakota, E.L., Kang, M.K. and Hartgerink, J.D., Nat. Chem., 2011, 3(10): 821

    Article  CAS  Google Scholar 

  115. Bakota, E.L., Aulisa, L., Galler, K.M. and Hartgerink, J.D., Biomacromolecules, 2011, 12(1): 82

    Article  CAS  Google Scholar 

  116. Aulisa, L., Dong, H. and Hartgerink, J.D., Biomacromolecules, 2009, 10(9): 2694

    Article  CAS  Google Scholar 

  117. Lindsey, S., Piatt, J.H., Worthington, P., Sonmez, C., Satheye, S., Schneider, J.P., Pochan, D.J. and Langhans, S.A., Biomacromolecules, 2015, 16(9): 2672

    Article  CAS  Google Scholar 

  118. Medina, S.H., Li, S., Howard, O.M.Z., Dunlap, M., Trivett, A., Schneider, J.P. and Oppenheim, J.J., Biomaterials, 2015, 53: 545

    Article  CAS  Google Scholar 

  119. Smith, D.J., Brat, G.A., Medina, S.H., Tong, D., Huang, Y., Grahammer, J., Furtmuller, G.J., Oh, B.C., Nagy-Smith, K.J., Walczak, P., Brandacher, G. and Schneider, J.P., Nat. Nanotechnol., 2016, 11(1): 95

    Article  CAS  Google Scholar 

  120. Frederix, P.W., Scott, G.G., Abul-Haija, Y.M., Kalafatovic, D., Pappas, C.G., Javid, N., Hunt, N.T., Ulijn, R.V. and Tuttle, T., Nat. Chem., 2015, 7(1): 30

    Article  CAS  Google Scholar 

  121. Kumar, V.A., Shi, S., Wang, B.K., Li, I.C., Jalan, A.A., Sarkar, B., Wickremasinghe, N.C. and Hartgerink, J.D., J. Am. Chem. Soc., 2015, 137(14): 4823

    Article  CAS  Google Scholar 

  122. Pappas, C.G., Frederix, P.W.J.M., Mutasa, T., Fleming, S., Abul-Haija, Y.M., Kelly, S.M., Gachagan, A., Kalafatovic, D., Trevino, J., Ulijn, R.V. and Bai, S., Chem. Commun., 2015, 51(40): 8465

    Article  CAS  Google Scholar 

  123. Conte, M.P., Singh, N., Sasselli, I.R., Escuder, B. and Ulijn, R.V., Chem. Commun., 2016, 52(96): 13889

    Article  CAS  Google Scholar 

  124. Kumar, V.A., Taylor, N.L., Shi, S.Y., Wickremasinghe, N.C., D'Souza, R.N. and Hartgerink, J.D., Biomaterials, 2015, 52: 71

    Article  CAS  Google Scholar 

  125. Kang, M.K., Colombo, J.S., D'Souza, R.N. and Hartgerink, J.D., Biomacromolecules, 2014, 15(6): 2004

    Article  CAS  Google Scholar 

  126. Kumar, V.A., Liu, Q., Wickremasinghe, N.C., Shi, S.Y., Cornwright, T.T., Deng, Y.X., Azares, A., Moore, A.N., Acevedo-Jake, A.M., Agudo, N.R., Pan, S., Woodside, D.G., Vanderslice, P., Willerson, J.T., Dixon, R.A. and Hartgerink, J.D., Biomaterials, 2016, 98: 113

    Article  CAS  Google Scholar 

  127. Kumar, V.A., Taylor, N.L., Shi, S.Y., Wang, B.K., Jalan, A.A., Kang, M.K., Wickremasinghe, N.C. and Hartgerink, J.D., ACS Nano, 2015, 9(1): 860

    Article  CAS  Google Scholar 

  128. Wickremasinghe, N.C., Kumar, V.A., Shi, S.Y. and Hartgerink, J.D., ACS Biomater. Sci. Eng., 2015, 1(9): 845

    Article  CAS  Google Scholar 

  129. Cui, H., Pashuck, E.T., Velichko, Y.S., Weigand, S.J., Cheetham, A.G., Newcomb, C.J. and Stupp, S.I., Science, 2010, 327(5965): 555

    Article  CAS  Google Scholar 

  130. Hartgerink, J.D., Beniash, E. and Stupp, S.I., Science, 2001, 294(5547): 1684

    Article  CAS  Google Scholar 

  131. Silva, G.A., Czeisler, C., Niece, K.L., Beniash, E., Harrington, D.A., Kessler, J.A. and Stupp, S.I., Science, 2004, 303(5662): 1352

    Article  CAS  Google Scholar 

  132. Chung, E.J., Cheng, Y., Morshed, R., Nord, K., Han, Y., Wegscheid, M.L., Auffinger, B., Wainwright, D.A., Lesniak, M.S. and Tirrell, M.V., Biomaterials, 2014, 35(4): 1249

    Article  CAS  Google Scholar 

  133. Chung, E.J., Mlinar, L.B., Sugimoto, M.J., Nord, K., Roman, B.B. and Tirrell, M., Nanomed. Nanotechnol. Biol. Med., 2015, 11(2): 479

    Article  CAS  Google Scholar 

  134. Mlinar, L.B., Chung, E.J., Wonder, E.A. and Tirrell, M., Biomaterials, 2014, 35(30): 8678

    Article  CAS  Google Scholar 

  135. Trent, A., Ulery, B.D., Black, M.J., Barrett, J.C., Liang, S., Kostenko, Y., David, N.A. and Tirrell, M.V., AAPS J., 2015, 17(2): 380

    Article  CAS  Google Scholar 

  136. Lowik, D.W.P.M. and van Hest, J.C.M., Chem. Soc. Rev., 2004, 33(4): 234

    Article  Google Scholar 

  137. van den Heuvel, M., Baptist, H., Venema, P., van der Linden, E., Lowik, D.W.P.M. and van Hest, J.C.M., Soft Matter, 2011, 7(20): 9737

    Article  CAS  Google Scholar 

  138. Hamley, I.W. and Castelletto, V., Bioconjug. Chem., 2017, 28(3): 731

    Article  CAS  Google Scholar 

  139. Miravet, J.F., Escuder, B., Segarra-Maset, M.D., Tena-Solsona, M., Hamley, I.W., Dehsorkhi, A. and Castelletto, V., Soft Matter, 2013, 9(13): 3558

    Article  CAS  Google Scholar 

  140. Hamley, I.W., Soft Matter, 2011, 7(9): 4122

    Article  CAS  Google Scholar 

  141. Harrington, D.A., Cheng, E.Y., Guler, M.O., Lee, L.K., Donovan, J.L., Claussen, R.C. and Stupp, S.I., J. Biomed. Mater. Res. A, 2006, 78A(1): 157

    Article  CAS  Google Scholar 

  142. Webber, M.J., Kessler, J.A. and Stupp, S.I., J. Intern. Med., 2010, 267(1): 71

    Article  CAS  Google Scholar 

  143. Boekhoven, J. and Stupp, S.I., Adv. Mater., 2014, 26(11): 1642

    Article  CAS  Google Scholar 

  144. Lin, B.F., Megley, K.A., Viswanathan, N., Krogstad, D.V., Drews, L.B., Kade, M.J., Qian, Y.C. and Tirrell, M.V., J. Mater. Chem., 2012, 22(37): 19447

    Article  CAS  Google Scholar 

  145. Black, M., Trent, A., Kostenko, Y., Lee, J.S., Olive, C. and Tirrell, M., Adv. Mater., 2012, 24(28): 3845

    Article  CAS  Google Scholar 

  146. Soukasene, S., Toft, D.J., Moyer, T.J., Lu, H.M., Lee, H.K., Standley, S.M., Cryns, V.L. and Stupp, S.I., ACS Nano, 2011, 5(11): 9113

    Article  CAS  Google Scholar 

  147. Matson, J.B. and Stupp, S.I., Chem. Commun., 2011, 47(28): 7962

    Article  CAS  Google Scholar 

  148. Dehsorkhi, A., Castelletto, V. and Hamley, I.W., J. Pept. Sci., 2014, 20(7): 453

    Article  CAS  Google Scholar 

  149. Hamley, I.W., Angew. Chem. Int. Ed., 2007, 46(43): 8128

    Article  CAS  Google Scholar 

  150. Tysseling-Mattiace, V.M., Sahni, V., Niece, K.L., Birch, D., Czeisler, C., Fehlings, M.G., Stupp, S.I. and Kessler, J.A., J. Neurosci., 2008, 28(14): 3814

    Article  CAS  Google Scholar 

  151. Li, A., Hokugo, A., Yalom, A., Berns, E.J., Stephanopoulos, N., McClendon, M.T., Segovia, L.A., Spigelman, I., Stupp, S.I. and Jarrahy, R., Biomaterials, 2014, 35(31): 8780

    Article  CAS  Google Scholar 

  152. Berns, E.J., Alvarez, Z., Goldberger, J.E., Boekhoven, J., Kessler, J.A., Kuhn, H.G. and Stupp, S.I., Acta. Biomater., 2016, 37: 50

    Article  CAS  Google Scholar 

  153. Black, K.A., Lin, B.F., Wonder, E.A., Desai, S.S., Chung, E.J., Ulery, B.D., Katari, R.S. and Tirrell, M.V., Tissue Eng. Part A, 2015, 21(7-8): 1333

    Article  CAS  Google Scholar 

  154. Cinar, G., Ozdemir, A., Hamsici, S., Gunay, G., Dana, A., Tekinay, A.B. and Guler, M.O., Biomater. Sci., 2017, 5(1): 67

    Article  CAS  Google Scholar 

  155. Wan, Y.M., Wang, Z.N., Sun, J. and Li, Z.B., Langmuir, 2016, 32(30): 7512

    Article  CAS  Google Scholar 

  156. Wan, Y.M., Liu, L.B., Yuan, S.S., Sun, J. and Li, Z.B., Langmuir, 2017, 33(13): 3234

    Article  CAS  Google Scholar 

  157. Kuang, Y., Shi, J.F., Li, J., Yuan, D., Alberti, K.A., Xu, Q.B. and Xu, B., Angew. Chem. Int. Ed., 2014, 53(31): 8104

    Article  CAS  Google Scholar 

  158. Abul-Haija, Y.M., Roy, S., Frederix, P.W.J.M., Javid, N., Jayawarna, V. and Ulijn, R.V., Small, 2014, 10(5): 973

    Article  CAS  Google Scholar 

  159. Draper, E.R., Eden, E.G.B., McDonald, T.O. and Adams, D.J., Nat. Chem., 2015, 7(10): 849

    Article  CAS  Google Scholar 

  160. Vegners, R., Shestakova, I., Kalvinsh, I., Ezzell, R. and Janmey, P., J. Pept. Sci., 1995, 1(6): 371

    Article  CAS  Google Scholar 

  161. Shi, Y., Wang, J., Wang, H., Hu, Y., Chen, X. and Yang, Z., PloS one, 2014, 9(9): 106968

    Article  CAS  Google Scholar 

  162. Kuang, Y., Du, X.W., Zhou, J. and Xu, B., Adv. Healthc. Mater., 2014, 3(8): 1217

    Article  CAS  Google Scholar 

  163. Li, J., Kuang, Y., Shi, J.F., Zhou, J., Medina, J.E., Zhou, R., Yuan, D., Yang, C.H., Wang, H.M., Yang, Z.M., Liu, J.F., Dinulescu, D.M. and Xu, B., Angew. Chem. Int. Ed., 2015, 54(45): 13307

    Article  CAS  Google Scholar 

  164. Li, J., Shi, J., Medina, J.E., Zhou, J., Du, X., Wang, H., Yang, C., Liu, J., Yang, Z., Dinulescu, D.M. and Xu, B., Adv. Healthc. Mater., 2017

    Google Scholar 

  165. Zhou, J., Du, X.W., Yamagata, N. and Xu, B., J. Am. Chem. Soc., 2016, 138(11): 3813

    Article  CAS  Google Scholar 

  166. Zhou, J., Du, X.W., Gao, Y., Shi, J.F. and Xu, B., J. Am. Chem. Soc., 2014, 136(8): 2970

    Article  CAS  Google Scholar 

  167. Jayawarna, V., Ali, M., Jowitt, T.A., Miller, A.E., Saiani, A., Gough, J.E. and Ulijn, R.V., Adv. Mater., 2006, 18(5): 611

    Article  CAS  Google Scholar 

  168. Mahler, A., Reches, M., Rechter, M., Cohen, S. and Gazit, E., Adv. Mater., 2006, 18(11): 1365

    Article  CAS  Google Scholar 

  169. Fleming, S., Debnath, S., Frederix, P.W.J.M., Hunt, N.T. and Ulijn, R.V., Biomacromolecules, 2014, 15(4): 1171

    Article  CAS  Google Scholar 

  170. Pappas, C.G., Abul-Haija, Y.M., Flack, A., Frederix, P.W.J.M. and Ulijn, R.V., Chem. Commun., 2014, 50(73): 10630

    Article  CAS  Google Scholar 

  171. Raeburn, J., Alston, B., Kroeger, J., McDonald, T.O., Howse, J.R., Cameron, P.J. and Adams, D.J., Mater. Horizons, 2014, 1(2): 241

    Article  CAS  Google Scholar 

  172. Draper, E.R., Wallace, M., Schweins, R., Poole, R.J. and Adams, D.J., Langmuir, 2017, 33(9): 2387

    Article  CAS  Google Scholar 

  173. Cheetham, A.G., Zhang, P., Lin, Y.A., Lock, L.L. and Cui, H., J. Am. Chem. Soc., 2013, 135(8): 2907

    Article  CAS  Google Scholar 

  174. Lin, R. and Cui, H., Curr. Opin. Chem. Eng., 2015, 7: 75

    Article  Google Scholar 

  175. Cheetham, A.G., Ou, Y.C., Zhang, P. and Cui, H., Chem. Commun., 2014, 50(45): 6039

    Article  CAS  Google Scholar 

  176. Lin, Y.A., Cheetham, A.G., Zhang, P., Ou, Y.C., Li, Y., Liu, G., Hermida-Merino, D., Hamley, I.W. and Cui, H., ACS Nano, 2014, 8(12): 12690

    Article  CAS  Google Scholar 

  177. Ma, W., Cheetham, A.G. and Cui, H., Nano Today, 2016, 11(1): 13

    Article  CAS  Google Scholar 

  178. Cheetham, A.G., Lin, Y.A., Lin, R. and Cui, H., Acta Pharmacol. Sin., 2017, 38(6): 874

    Article  CAS  Google Scholar 

  179. Lin, R., Cheetham, A.G., Zhang, P., Lin, Y.A. and Cui, H., Chem. Commun., 2013, 49(43): 4968

    Article  CAS  Google Scholar 

  180. Cheetham, A.G., Zhang, P., Lin, Y.A., Lin, R. and Cui, H., J. Mater. Chem. B, 2014, 2(42): 7316

    Article  CAS  Google Scholar 

  181. Su, H., Zhang, P., Cheetham, A.G., Koo, J.M., Lin, R., Masood, A., Schiapparelli, P., Quinones-Hinojosa, A. and Cui, H., Theranostics, 2016, 6(7): 1065

    Article  CAS  Google Scholar 

  182. Ma, W., Su, H., Cheetham, A.G., Zhang, W., Kan, Q. and Cui, H., J. Control. Release, 2017, DOI: 10.1016/j.jconrel.2017.01.015

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland, 21218, USA

    Hao Su, Yuzhu Wang, Caleb F. Anderson, Jin Mo Koo, Han Wang & Honggang Cui

  2. Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland, 21218, USA

    Hao Su, Yuzhu Wang, Caleb F. Anderson, Jin Mo Koo, Han Wang & Honggang Cui

  3. Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Honggang Cui

  4. Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD, 21231, USA

    Honggang Cui

Authors
  1. Hao Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuzhu Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Caleb F. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jin Mo Koo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Han Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Honggang Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Honggang Cui.

Additional information

The work was financially supported by the National Science Foundation (No. DMR 1255281).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Su, H., Wang, Y., Anderson, C.F. et al. Recent progress in exploiting small molecule peptides as supramolecular hydrogelators. Chin J Polym Sci 35, 1194–1211 (2017). https://doi.org/10.1007/s10118-017-1998-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10118-017-1998-2

Keywords

Search

Navigation