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A General Method to Prepare Peptide-Based Supramolecular Hydrogels

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Peptide Self-Assembly

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1777))

Abstract

As a type of versatile soft materials, supramolecular hydrogels made of peptides have received increasing research attention in past decade and have found useful applications in many areas. Meanwhile, numerous methods have been reported to initiate hydrogelation via noncovalent intermolecular interactions. Generally, most hydrogelation starts from a homogeneous solution and reaches a balance of water hydration and hydrophobic interactions, thereby resulting in hydrogelation. Here, we describe a general method to prepare supramolecular hydrogels of small peptides, and describe two examples to demonstrate hydrogel preparation.

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Acknowledgments

This work was partially supported by grant from NIH (CA142746) and Keck Foundation.

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Authors and Affiliations

  1. Brandeis University, Waltham, MA, USA

    Dan Yuan, Junfeng Shi, Ning Zhou & Bing Xu

Authors
  1. Dan Yuan
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  2. Junfeng Shi
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  3. Ning Zhou
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  4. Bing Xu
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Corresponding author

Correspondence to Bing Xu .

Editor information

Editors and Affiliations

  1. Department of Chemistry, University of Rochester, Rochester, New York, USA

    Bradley L. Nilsson

  2. Department of Medicinal Chemistry, Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA

    Todd M. Doran

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Yuan, D., Shi, J., Zhou, N., Xu, B. (2018). A General Method to Prepare Peptide-Based Supramolecular Hydrogels. In: Nilsson, B., Doran, T. (eds) Peptide Self-Assembly. Methods in Molecular Biology, vol 1777. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7811-3_9

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  • DOI: https://doi.org/10.1007/978-1-4939-7811-3_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7809-0

  • Online ISBN: 978-1-4939-7811-3

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