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Antibacterial behaviour of quaternized poly(vinyl chloride)-g-poly(4-vinyl pyridine) graft copolymers

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Abstract

Amphiphilic graft copolymers consisting of poly(vinyl chloride) (PVC) main chains and poly(4-vinyl pyridine) (P4VP) side chains were synthesized via atom transfer radical polymerization (ATRP) using direct initiation of chlorine atoms. The successful synthesis of PVC-g-P4VP graft copolymers was confirmed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis showed that PVC-g-P4VP exhibited microphase-separated, ordered structure with 37.6 nm of domain spacing, which was not observed in neat PVC. For antibacterial applications, the tertiary nitrogen atoms of PVC-g-P4VP was quaternized using 1-bromohexane, as confirmed by FTIR measurements. Bacteria including Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Bacillus cereus (B. cereus), and Pseudomonas aeruginosa (P. aeruginosa) were completely killed in 24 h on the quaternized PVC-g-P4VP (46% grafting) surface, indicating its excellent antibacterial behavior while it showed to be cytotoxic to mammalian cell.

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Authors and Affiliations

  1. Department of Life Science, Dongguk University-Seoul, 3-26 Phil-dong, Chung-gu, Seoul, 100-715, South Korea

    Madhumita Patel & Jung-Suk Sung

  2. Department of Chemical and Biomolecular Engineering, Yonsei University, 262 Seongsanno, Seodaemun-gu, Seoul, 120-749, South Korea

    Rajkumar Patel, Won Seok Chi & Jong Hak Kim

  3. Department of Chemistry and Nano Science, EwhaWomans University, Global Top 5 Research Program, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea

    Madhumita Patel

Authors
  1. Madhumita Patel
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  2. Rajkumar Patel
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  3. Won Seok Chi
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  4. Jong Hak Kim
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  5. Jung-Suk Sung
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Corresponding authors

Correspondence to Rajkumar Patel, Jong Hak Kim or Jung-Suk Sung.

Additional information

This work was financially supported by a National Research Foundation (NRF) grant funded by the Korean government (MEST) through the Core Research Program (2012R1A2A2A02011268), Agriculture Research Center program of Ministry for Food, Agriculture, Forestry, and Fisheries (IPET 112051-3), the Korea CCS R&D Center and the Energy Efficiency & Resources of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Ministry of Knowledge Economy (20122010100040).

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Patel, M., Patel, R., Chi, W.S. et al. Antibacterial behaviour of quaternized poly(vinyl chloride)-g-poly(4-vinyl pyridine) graft copolymers. Chin J Polym Sci 33, 265–274 (2015). https://doi.org/10.1007/s10118-015-1577-3

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  • DOI: https://doi.org/10.1007/s10118-015-1577-3

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