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Model study of combined electrical and near-infrared neural stimulation on the bullfrog sciatic nerve

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Abstract

This paper implemented a model study of combined electrical and near-infrared (808 nm) neural stimulation (NINS) on the bullfrog sciatic nerve. The model includes a COMSOL model to calculate the electric-field distribution of the surrounding area of the nerve, a Monte Carlo model to simulate light transport and absorption in the bullfrog sciatic nerve during NINS, and a NEURON model to simulate the neural electrophysiology changes under electrical stimulus and laser irradiation. The optical thermal effect is considered the main mechanism during NINS. Therefore, thermal change during laser irradiation was calculated by the Monte Carlo method, and the temperature distribution was then transferred to the NEURON model to stimulate the sciatic nerve. The effects on thermal response by adjusting the laser spot size, energy of the beam, and the absorption coefficient of the nerve are analyzed. The effect of the ambient temperature on the electrical stimulation or laser stimulation and the interaction between laser irradiation and electrical stimulation are also studied. The results indicate that the needed stimulus threshold for neural activation or inhibition is reduced by laser irradiation. Additionally, the needed laser energy for blocking the action potential is reduced by electrical stimulus. Both electrical and laser stimulation are affected by the ambient temperature. These results provide references for subsequent animal experiments and could be of great help to future basic and applied studies of infrared neural stimulation (INS).

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Acknowledgments

This work was supported by the Nature Science Foundation of China Grant (No. 31500796).

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  1. Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Institution of Biomedical Engineering, Jinan University, Guangzhou, Guangdong, 510632, China

    Mengxian You & Zongxia Mou

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  1. Mengxian You
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  2. Zongxia Mou
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Correspondence to Zongxia Mou.

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This is a simulation study, so for this type of study formal consent is not required. And this article does not contain any studies with human participants or animals performed by any of the authors.

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You, M., Mou, Z. Model study of combined electrical and near-infrared neural stimulation on the bullfrog sciatic nerve. Lasers Med Sci 32, 1163–1172 (2017). https://doi.org/10.1007/s10103-017-2222-x

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