Abstract
Selective stimulation of the nervous system is an important way to improve the therapeutic efficacy and minimize side effects. This paper introduces an improved method using combined electrical and near-infrared stimulation to realize selective excitation and inhibition of different sciatic nerve branches. Both the electrical stimulation and the near-infrared laser are added to the main trunk of the sciatic nerve, and gold nanorods are injected into the light irradiation point of the nerve to increase the absorption of light. Two cuff recording electrodes are added to the two sciatic nerve branches, respectively. The compound nerve action potential recorded by the cuff electrode is transmitted to the physiological signal instrument. In the experiment, selective activation and inhibition of the two nerve branches are achieved by adjusting the electrical stimulation parameters, the light stimulus parameters and the location of the light. These results demonstrate that combined electrical and near-infrared stimulation, which can effectively activate or suppress the different nerve fibers in the nerve fiber bundle, is suitable for selective regulation of peripheral nerve. Meanwhile, the photoelectric combined stimulation can reduce both the electrical energy and light energy needed for the stimulation, and reduce the electrical damage and light damage to the nerve.
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References
J.M. Cayce, R.M. Friedman, E.D. Jansen, A. Mahavaden-Jansen, A.W. Roe, NeuroImage 57(1), 155–166 (2011)
J.M. Cayce, R.M. Friedman, G. Chen, et al., NeuroImage 84, 181–190 (2014)
G.M. Dittami, S.M. Rajguru, R.A. Lasher, R.W. Hitchcock, R.D. Rabbitt, J. Physiol. 589(6), 1295–1306 (2011)
A.R. Duke, J.M. Cayce, J.D. Malphrus, et al., J. Biomed. Opt. 14(6), 060501 (2009)
A.R. Duke, E. Peterson, M.A. Mackanos, et al., J. Neural Eng. 9(6), 066006 (2012a)
A.R. Duke, H. Lu, M.W. Jenkins, H.J. Chiel, E.D. Jansen, J. Neural Eng. 9(3), 036003 (2012b)
A.R. Duke, M.W. Jenkins, H. Lu, et al., Sci. Rep. 3, 2600 (2013)
K. Eom, J. Kim, J.M. Choi, et al., Small 10(19), 3853–3857 (2014)
N.M. Fried, G.A. Lagoda, N.J. Scott, L.M. Su, A.L. Burnett, J. Endourol. 22(3), 409–414 (2008)
A.D. Izzo, C.P. Richter, E.D. Jansen, J.T. Walsh, Lasers Surg. Med. 38(8), 745–753 (2006)
A.D. Izzo, E. Suh, J. Pathria, et al., J. Biomed. Opt. 12(2), 021008 (2007)
M.W. Jenkins, A.R. Duke, S. Gu, et al., Nat. Photonics 4, 623–626 (2010)
A. Jonsson et al., Proc. Natl. Acad. Sci. 113(34), 9440–9445 (2016)
E.J. Katz, I.K. Ilev, V. Krauthamer, H. Kim do, D. Weinreich, Neuroreport 21, 662–666 (2010)
S. Lee, S. Sheshadri, Z. Xiang, et al., Sensors Actuators B Chem. 242, 1165–1170 (2017)
M.E. Llewellyn, K.R. Thompson, K. Deisseroth, S. Delp, Nat. Med. 16, 1161 (2010)
C. Marin, E. Fernandez, Front Neuroeng 3(8), 1662–6443 (2010)
R.G. McCaughey, C. Chlebicki, B.J.F. Wong, Lasers Surg. Med. 42(1), 69–75 (2010)
Z.X. Mou, I. Triantis, V.M. Woods, C. Toumazou, K. Nikolic, IEEE Trans. Biomed. Eng. 59(6), 1758–1769 (2012)
Z.X. Mou, M.X. You, W. Xue, Lasers Med. Sci. 33(3), 1–6 (2018)
C. Paviolo, J.W. Haycock, J. Yong, et al., Biotechnol. Bioeng. 110(8), 2277–2291 (2013)
G. Paxinos, The Rat Nervous System, 3rd edn. (Elsevier, Sydney, 2004)
C.P. Richter, A.I. Matic, J.D. Wells, E.D. Jansen, J.T. Walsh, Laser Photonics Rev. 5, 68–80 (2011)
M.G. Shapiro, K. Homma, S. Villarreal, C.P. Richter, F. Bezanilla, Nat. Commun. 3, 736 (2012)
I.U. Teudt, A.E. Nevel, A.D. Izzo, et al., Laryngoscope 117(9), 1641–1647 (2007)
A.C. Thompson, P.R. Stoddart, E.D. Jansen, Curr Mol Imaging 3(2), 162–177 (2014)
D.J. Tyler, D.M. Durand, IEEE Trans Neural Syst Rehabil Eng 10(4), 294–303 (2002)
A. Vogel, V. Venugopalan, Chem. Rev. 103, 2079–2079 (2003)
Y.C. Wang, L. Guo, Front. Neurosci. 10(69) (2016)
J.D. Wells, C. Kao, E.D. Jansen, P.E. Konrad, A. Mahadevan-Jansen, J. Biomed. Opt. 10(6), 064003 (2005)
J.D. Wells, C. Kao, P. Konrad, et al., Biophys. J. 93(7), 2567–2580 (2007a)
J.D. Wells, S. Thomsen, P. Whitaker, et al., Lasers Surg. Med. 39(6), 513–526 (2007b)
J.D. Wells, P. Konrad, C. Kao, E.D. Jansen, A. Mahadevan-Jansen, J. Neurosci. Methods 163(2), 326–337 (2007c)
J. Yong, K. Needham, W.G. Brown, et al., Adv Healthc Mater 3(11), 1862–1868 (2014)
S. Yoo, J.H. Park, Y. Nam, ACS Nano 13(1), 544–551 (2019)
M.X. You, Z.X. Mou, Lasers Med. Sci. 32(5), 1163–1172 (2017)
K. Zhang, E. Katz, D.H. Kim, J.U. Kang, I.K. Ilev, Electron. Lett. 46(2), 118–120 (2010)
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This work was supported by the National Nature Science Foundation of China Grant (grant number: 31500796).
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You, M., Zhou, R. & Mou, Z. Selective stimulation of bullfrog sciatic nerve by gold nanorod assisted combined electrical and near-infrared stimulation. Biomed Microdevices 21, 76 (2019). https://doi.org/10.1007/s10544-019-0428-3
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DOI: https://doi.org/10.1007/s10544-019-0428-3