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The role of time to positive blood cultures in enhancing the predictive capability of DENOVA score for diagnosing infective endocarditis in patients with Enterococcus faecalis bacteremia

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Abstract

DENOVA-score is useful to stratify the risk of infective endocarditis (IE) in Enterococcus faecalis bacteremia. Recently, time to positive (TTP) of blood cultures has also been related with a higher risk of IE. The objective was to evaluate DENOVA- score with TTP to improve its specificity. We performed a retrospective, case–control study in adult patients with E. faecalis bacteremia. Thirty-nine patients with definite E. faecalis IE and 82 with E. faecalis bacteremia were included. The addition of a TTP ≤ 8 h to DENOVA-score did not improve the diagnostic accuracy of this score.

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Data availability

No datasets were generated or analysed during the current study.

References

  1. Arias CA, Murray BE (2012) The rise of the Enterococcus: beyond vancomycin resistance. Nat Rev Microbiol 10:266–278. https://doi.org/10.1038/nrmicro2761

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Romay E, Pericàs JM, García-País MJ, Hernández-Meneses M, Ayuso B, García-González J et al (2022) Relationship among Streptococcus gallolyticus Subsp. gallolyticus, Enterococcus faecalis and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series. J Clin Med 11:2181. https://doi.org/10.3390/jcm11082181

    Article  PubMed  PubMed Central  Google Scholar 

  3. Suppli M, Aabenhus R, Harboe ZB, Andersen LP, Tvede M, Jensen J-US (2011) Mortality in enterococcal bloodstream infections increases with inappropriate antimicrobial therapy. Clin Microbiol Infect 17:1078–83. https://doi.org/10.1111/j.1469-0691.2010.03394.x

    Article  CAS  PubMed  Google Scholar 

  4. Billington EO, Phang SH, Gregson DB, Pitout JDD, Ross T, Church DL et al (2014) Incidence, Risk Factors, and Outcomes for Enterococcus spp. Blood Stream Infections: A Population-Based Study. Int J Infect Dis 26:76–82. https://doi.org/10.1016/j.ijid.2014.02.012

    Article  CAS  PubMed  Google Scholar 

  5. Pinholt M, Østergaard C, Arpi M, Bruun NE, Schønheyder HC, Gradel KO et al (2014) Incidence, clinical characteristics and 30-day mortality of enterococcal bacteraemia in Denmark 2006–2009: a population-based cohort study. Clin Microbiol Infect 20:145–151. https://doi.org/10.1111/1469-0691.12236

    Article  CAS  PubMed  Google Scholar 

  6. Bouza E, Kestler M, Beca T, Mariscal G, Rodríguez-Créixems M, Bermejo J et al (2015) The NOVA score: a proposal to reduce the need for transesophageal echocardiography in patients with enterococcal bacteremia. Clin Infect Dis 60:528–535. https://doi.org/10.1093/cid/ciu872

    Article  PubMed  Google Scholar 

  7. Berge A, Krantz A, Östlund H, Nauclér P, Rasmussen M (2019) The DENOVA score efficiently identifies patients with monomicrobial Enterococcus faecalis bacteremia where echocardiography is not necessary. Infection 47:45–50. https://doi.org/10.1007/s15010-018-1208-3

    Article  PubMed  Google Scholar 

  8. Haimi-Cohen Y, Vellozzi EM, Rubin LG (2002) Initial concentration of Staphylococcus epidermidis in simulated pediatric blood cultures correlates with time to positive results with the automated, continuously monitored BACTEC blood culture system. J Clin Microbiol 40:898–901. https://doi.org/10.1128/JCM.40.3.898-901.2002

    Article  PubMed  PubMed Central  Google Scholar 

  9. Siméon S, Moing VL, Tubiana S, Duval X, Fournier D, Lavigne J-P et al (2019) Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia. Clin Microbiol Infect 25:481–488. https://doi.org/10.1016/j.cmi.2018.07.015

    Article  PubMed  Google Scholar 

  10. Kahn F, Resman F, Bergmark S, Filiptsev P, Nilson B, Gilje P et al (2021) Time to blood culture positivity in Staphylococcus aureus bacteraemia to determine risk of infective endocarditis. Clin Microbiol Infect 27:1345.e7-1345.e12. https://doi.org/10.1016/j.cmi.2020.11.007

    Article  CAS  PubMed  Google Scholar 

  11. Khatib R, Riederer K, Saeed S, Johnson LB, Fakih MG, Sharma M et al (2005) Time to positivity in Staphylococcus aureus bacteremia: possible correlation with the source and outcome of infection. Clin Infect Dis 41:594–598. https://doi.org/10.1086/432472

    Article  PubMed  Google Scholar 

  12. Chen S-Y, Weng T-H, Tseng W-P, Fu C-M, Lin H-W, Liao C-H et al (2018) Value of blood culture time to positivity in identifying complicated nontyphoidal Salmonella bacteremia. Diagn Microbiol Infect Dis 91:210–216. https://doi.org/10.1016/j.diagmicrobio.2018.02.005

    Article  PubMed  Google Scholar 

  13. Cillóniz C, Ceccato A, de la Calle C, Gabarrús A, Garcia-Vidal C, Almela M et al (2017) Time to blood culture positivity as a predictor of clinical outcomes and severity in adults with bacteremic pneumococcal pneumonia. PLoS ONE 12:1–18. https://doi.org/10.1371/journal.pone.0182436

    Article  CAS  Google Scholar 

  14. Willmann M, Kuebart I, Vogel W, Flesch I, Markert U, Marschal M et al (2013) Time to positivity as prognostic tool in patients with Pseudomonas aeruginosa bloodstream infection. J Infect 67:416–423. https://doi.org/10.1016/j.jinf.2013.06.012

    Article  PubMed  Google Scholar 

  15. Oldberg K, Thorén R, Nilson B, Gilje P, Inghammar M, Rasmussen M (2021) Short time to blood culture positivity in Enterococcus faecalis infective endocarditis. Eur J Clin Microbiol Infect Dis 40:1657–1664. https://doi.org/10.1007/s10096-021-04210-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J-P, Del Zotti F et al (2015) 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 36:3075–128. https://doi.org/10.1093/eurheartj/ehv319

    Article  PubMed  Google Scholar 

  17. The European Committee on Antimicrobial Susceptibility Testint (2023) Breakpoint tables for interpretation of MICs and zone diameters. Available from: https://eucast.org/clinical_breakpoints

  18. Rosselli Del Turco E, Bartoletti M, Dahl A, Cervera C, Pericàs JM (2021) How do I manage a patient with enterococcal bacteraemia? Clin Microbiol Infect 27:364–371. https://doi.org/10.1016/j.cmi.2020.10.029

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Infectious Diseases Unit, Internal Medicine Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain

    M Teresa Pérez-Rodríguez, Olalla Lima, Martín Garrido, Alexandre Pérez-González, Antía Amoedo, Adrián Sousa, Ana López & Martín Rubianes

  2. Galicia Sur Health Research Institute, Vigo, Spain

    M Teresa Pérez-Rodríguez, Olalla Lima, Lucía Martínez-Lamas, Alexandre Pérez-González, Alejandro Araújo, Adrián Sousa, Ana López & Xurxo Cabrera

  3. Microbiology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain

    Anniris Rincón, Lucía Martínez-Lamas & Xurxo Cabrera

Authors
  1. M Teresa Pérez-Rodríguez
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  2. Olalla Lima
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  3. Martín Garrido
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  4. Anniris Rincón
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  5. Lucía Martínez-Lamas
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  6. Alexandre Pérez-González
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  7. Alejandro Araújo
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  8. Antía Amoedo
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  9. Adrián Sousa
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  10. Ana López
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  11. Xurxo Cabrera
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  12. Martín Rubianes
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Contributions

Draft manuscript preparation: OL, AAB, MPR

Data collection: MG, AR, APG, AA, AL, XC

Study conception and design: MPR, MR

Analysis and interpretation of results: AS, AL, LML

All authors reviewed the manuscript.

Corresponding author

Correspondence to M Teresa Pérez-Rodríguez.

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Ethical approval

The study protocol was evaluated by the Bioethics Committee (registration code 2022/440). Due to the retrospective design of the study, informed consent was not required, in accordance with the Declaration of Helsinki.

Conflict of interest

None of the authors have any conflict of interest.

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Pérez-Rodríguez, M., Lima, O., Garrido, M. et al. The role of time to positive blood cultures in enhancing the predictive capability of DENOVA score for diagnosing infective endocarditis in patients with Enterococcus faecalis bacteremia. Eur J Clin Microbiol Infect Dis (2024). https://doi.org/10.1007/s10096-024-04843-6

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  • DOI: https://doi.org/10.1007/s10096-024-04843-6

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