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Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

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Abstract

We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all β-lactams. A duplication of the tetrapeptide S569AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K583TG catalytic motif, was associated with this unusual phenotype.

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Acknowledgments

This work was partially supported by the Medical School of the University of Thessalia (grant no. 3917).

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Authors and Affiliations

  1. Department of Microbiology, University Hospital of Larissa, Larissa, Greece

    S. D. Kotsakis, A. Liakopoulos & E. Petinaki

  2. Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece

    S. D. Kotsakis & L. S. Tzouvelekis

  3. Department of Microbiology, Medical School, University of Athens, M. Asias 75, Athens, 11527, Greece

    L. S. Tzouvelekis

  4. Laboratory of Clinical Microbiology, Attikon University Hospital of Athens, Athens, Greece

    L. Zerva

Authors
  1. S. D. Kotsakis
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  2. L. S. Tzouvelekis
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  3. L. Zerva
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  4. A. Liakopoulos
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  5. E. Petinaki
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Correspondence to L. S. Tzouvelekis.

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Kotsakis, S.D., Tzouvelekis, L.S., Zerva, L. et al. Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams. Eur J Clin Microbiol Infect Dis 31, 169–172 (2012). https://doi.org/10.1007/s10096-011-1289-8

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  • DOI: https://doi.org/10.1007/s10096-011-1289-8

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