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Paediatric pneumococcal disease in Central Europe

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Abstract

Streptococcus pneumoniae causes considerable global paediatric morbidity and mortality, despite the availability of safe and effective pneumococcal conjugate vaccines (PCVs). To justify the introduction of PCVs, accurate information on the burden of disease is required. Here, we present an appraisal of the pneumococcal epidemiological situation in 11 Central European countries. The data are based on study findings presented at the 12th Central European Vaccine Advisory Group (CEVAG) meeting, held on 21–22 May 2010 in Sofia, Bulgaria, and a literature review of the PubMed database using the search terms ‘pneumococcal’ or ‘Streptococcus pneumoniae’, in combination with ‘otitis media’, ‘pneumonia’, ‘meningitis’ or ‘bacteraemia/sepsis’, and ‘[Central European country name]’. The incidence of pneumococcal disease appears to be lower in Central Europe than previously reported for Europe as a whole, with the highest risk in infants aged 0–2 years. The fatality rates in the under fives from invasive infections are up to 40%. A paucity of comprehensive country-specific data on pneumococcal disease burden arises from the lack of homogenous surveillance programmes. Standardised, active surveillance systems are required for the accurate evaluation of the pneumococcal disease burden in the region. Only then can the need for vaccination be addressed.

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Acknowledgements

Preparation of this report was supported by an educational grant from GlaxoSmithKline and Pfizer. Editorial assistance was provided by Dr. Julianna Solomons of Wells Healthcare, funded with support from GlaxoSmithKline and Pfizer.

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Authors and Affiliations

  1. Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic

    R. Prymula & R. Chlibek

  2. University Hospital Hradec Kralove, Hradec Kralove, Czech Republic

    R. Prymula

  3. Vilnius University Clinic of Children’s Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania

    I. Ivaskeviciene & V. Usonis

  4. Infectious Diseases Hospital, Sofia, Bulgaria

    A. Mangarov

  5. National Institute of Child Health, Budapest, Hungary

    Zs. Mészner

  6. Pediatric Clinic, University Hospital ‘Aleksandrovska’, Sofia, Bulgaria

    P. Perenovska

  7. Department of Pediatrics, University Hospital Center, Zagreb, Croatia

    D. Richter

  8. Division of Infectious Disease and Clinical Microbiology, University of Istanbul, Istanbul, Turkey

    N. Salman

  9. Pediatric Clinic, University Hospital, Trencin, Slovakia

    P. Šimurka

  10. Children’s Clinic of Tartu University Hospital, Tartu, Estonia

    E. Tamm

  11. Paediatric Infectious Diseases Department, University of Zagreb, Zagreb, Croatia

    G. Tešović

  12. Department of Paediatric Infectious Diseases, Children’s Faculty Hospital, Košice, Slovakia

    I. Urbancikova

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  1. R. Prymula
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Prymula, R., Chlibek, R., Ivaskeviciene, I. et al. Paediatric pneumococcal disease in Central Europe. Eur J Clin Microbiol Infect Dis 30, 1311–1320 (2011). https://doi.org/10.1007/s10096-011-1241-y

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