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A decade-long surveillance of nasopharyngeal colonisation with Streptococcus pneumoniae among children attending day-care centres in south-eastern France: 1999–2008

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Abstract

The antimicrobial resistance and serotype distribution of Streptococcus pneumoniae (SP) among children attending day-care centres in south-eastern France were monitored from 1999 to 2008, before and after interventions promoting prudent antibiotic use initiated in 2000 and the availability of pneumococcal conjugate vaccine in 2003. Antibiotic susceptibility and serotypes of SP isolates were determined on nasopharyngeal samples of children aged 3-40 months attending day-care centres, from January to March 1999, 2002, 2004, 2006 and 2008. SP carriage fell from 54% to 45%, and SP with diminished susceptibility to penicillin (PDSP) fell from 34% to 19%. Antibiotic prescriptions dropped from 63% to 38% of children, but third-generation cephalosporins were increasingly prescribed. The overall antibiotic susceptibility increased. Over 90% of the children had received at least one vaccine dose in 2008. Vaccine serotypes 6B, 9V, 19F and 23F (76%) in 1999 were replaced by non-vaccine types (95%) in 2008, among which were 15 (20%), 19A (15%), 23A/B (10%) and 6A (9%). Serotypes 6A, 19A and 15 accounted for over 50% of PDSP strains in 2008 versus 6% in 1999. Children now mostly harbour non-vaccine types; however, PDSP isolates are mainly recruited among these. Vaccine-related benefits may be threatened by combined vaccine- and antibiotic-driven selective pressure.

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Acknowledgements

The authors are grateful to the directors and staff of the day-care centres and to the parents and children who collaborated in the study.

These surveys were supported by Produits Roche, Wyeth Pharmaceuticals and the Nice University Hospital Program for Clinical Research, Nice, France.

These results were presented at the 46th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Washington, DC, October 2008.

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Authors and Affiliations

  1. Public Health Department, Hôpital de l’Archet, CHU de Nice, BP 3079, 06202, Nice cedex 3, France

    B. Dunais, P. Bruno-Bazureault, H. Carsenti-Dellamonica, P. Touboul & C. Pradier

  2. Département de Santé Publique, Hôpital l’Archet 1, BP 79, 06202, Nice cedex 3, France

    B. Dunais

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  1. B. Dunais
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  2. P. Bruno-Bazureault
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  3. H. Carsenti-Dellamonica
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  4. P. Touboul
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  5. C. Pradier
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Correspondence to B. Dunais.

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Dunais, B., Bruno-Bazureault, P., Carsenti-Dellamonica, H. et al. A decade-long surveillance of nasopharyngeal colonisation with Streptococcus pneumoniae among children attending day-care centres in south-eastern France: 1999–2008. Eur J Clin Microbiol Infect Dis 30, 837–843 (2011). https://doi.org/10.1007/s10096-011-1154-9

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  • DOI: https://doi.org/10.1007/s10096-011-1154-9

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