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The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review

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Abstract

Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease, which is characterized by the selective loss of the upper and lower motor neurons. The pathogenesis of ALS remains to be elucidated and has been connected to genetic, environmental and immune conditions. Evidence from clinical and experimental studies has suggested that the immune system played an important role in ALS pathophysiology. Autoantibodies are essential components of the immune system. Several autoantibodies directed at antigens associated with ALS pathogenesis have been identified in the serum and/or cerebrospinal fluid of ALS patients. The aim of this review is to summarize the presence and clinical significance of autoantibodies in ALS.

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  1. Shen Liu, Ye Hong, and Bian-Rong Wang contributed equally.

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  1. Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 210006, PR China

    Shen Liu, Ye Hong, Hong-Dong Zhao, Teng Jiang, Ying-Dong Zhang & Jian-Quan Shi

  2. Department of Neurology, Geriatric Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210006, PR China

    Bian-Rong Wang

  3. The Second Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu Province, 211166, PR China

    Zi-Qiao Wei

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Liu, ., Hong, Y., Wang, BR. et al. The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review. Neurol Sci (2024). https://doi.org/10.1007/s10072-024-07581-x

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