Abstract
In a number of experimental situations exogenously administered gangliosides have been demonstrated to speed recovery from axonotmesis. First demonstrated for the pre-and postganglionic sympathetic fibers of the cat nictitating membrane,1 it has now been demonstrated also for the rat sciatic nerve2 and rat tail nerve.3 The mechanism of action seems to be stimulation of the sprouting process.3,4 Hence, gangliosides would be expected to be beneficial in conditions such as traumatic nerve injury and mononeuritis from focal nerve infarction. Therapy would reduce the time of disability. Additionally, if regrowth of nerve is sometimes limited by fibrosis in the region of injury, then rapid growth out of this region would improve the quality of recovery.
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© 1984 Plenum Press, New York
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Hallett, M., Harrington, H., Tyler, H.R., Flood, T., Slater, N. (1984). Trials of Ganglioside Therapy for Amyotrophic Lateral Sclerosis and Diabetic Neuropathy. In: Ledeen, R.W., Yu, R.K., Rapport, M.M., Suzuki, K. (eds) Ganglioside Structure, Function, and Biomedical Potential. Advances in Experimental Medicine and Biology, vol 174. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1200-0_48
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DOI: https://doi.org/10.1007/978-1-4684-1200-0_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1202-4
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