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No causal link between age at menopause and multiple sclerosis onset and severity: a Mendelian randomization study

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Fig. 1

Data availability

Data supporting the findings of this study are available from the article/Supplementary material. Supplementary material includes Table S1, references 6–17.

References

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Acknowledgements

The authors thank the generous sharing of GWAS summary statistics from the ReproGen consortium, the International Multiple Sclerosis Genetics Consortium (IMSGC) and the UK Biobank (UKB).

Funding

This work was supported by the Department of science and Technology of Sichuan Province (2020YFS0219 and 2021YFS0173), and 1·3·5 project for disciplines of excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University (Grant No. 21HXFH041).

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Author notes

  1. Dongren Sun and Liangdan Tu contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    Dongren Sun, Liangdan Tu, Rui Wang, Ziyan Shi & Hongyu Zhou

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  1. Dongren Sun
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  2. Liangdan Tu
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  3. Rui Wang
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  4. Ziyan Shi
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  5. Hongyu Zhou
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Contributions

H. Z. conceived and designed the overall research. D.S. and L.T. collected and analyzed the data, and wrote the first draft of the manuscript. All authors were involved in the collection and monitoring of the data. All authors reviewed and agreed to the submitted version.

Corresponding author

Correspondence to Hongyu Zhou.

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Ethical approval

Not applicable. The present MR analysis was based on summary data from previous studies that had achieved written informed consent and ethics approval.

Competing interests

The authors declare no competing interests.

Informed consent

All analyses were performed using publicly available GWAS datasets. The GWAS studies cited in this research have received approval from their respective ethical review boards and have complied with informed consent requirements from participants.

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Supplementary Information

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Supplementary file1 (DOCX 17 KB)

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Sun, D., Tu, L., Wang, R. et al. No causal link between age at menopause and multiple sclerosis onset and severity: a Mendelian randomization study. Neurol Sci 45, 1287–1290 (2024). https://doi.org/10.1007/s10072-023-07145-5

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  • DOI: https://doi.org/10.1007/s10072-023-07145-5

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