Abstract
Purpose
Dizziness and vertigo are caused by multiple etiologies, including cerebrovascular ischemic events. However, identifying cerebrovascular ischemic events as a cause of dizziness and vertigo remains a challenge. We tried to assess the value of fibrinogen (FIB) in identifying of cerebral ischemic event in patients with dizziness/vertigo.
Methods
The study enrolled patients with dizziness/vertigo presented within 72 h in a tertiary hospital. The plasma FIB levels were measured in all participants. According to the final diagnosis, participants were divided into cerebral ischemic events group and non-cerebrovascular diseases group. Multivariate logistic regression was performed to explore the association between FIB and cerebral ischemic events. The receiver operating characteristic curve was performed, and the nomogram was constructed to evaluate the overall prediction ability of FIB in cerebral ischemic event.
Results
A total of 298 participants were enrolled in our study, of 126 cerebral ischemic events patients. Multivariate logistic regression analysis showed that FIB was independently associated with cerebral ischemic event in patients with dizziness (OR = 1.84, 95%CI [1.15, 2.92], p = 0.010). The cut-off value of FIB in predicting cerebral ischemic event was 2.43 g/L (AUC = 0.658). The nomogram showed that higher FIB level was associated with a greater risk of cerebral ischemic event (C-index = 0.800).
Conclusions
Our study suggested that FIB may be a useful biochemical parameter for identifying cerebral ischemic event in patients with dizziness/vertigo.
Similar content being viewed by others
References
Mendel B, Bergenius J, Langius-Eklof A (2010) Dizziness: a common, troublesome symptom but often treatable. J Vestib Res 20(5):391–398
Powell G, Derry-Sumner H, Rajenderkumar D et al (2020) Persistent postural perceptual dizziness is on a spectrum in the general population. Neurology 94(18):e1929–e1938
Kaski D (2020) Neurological update: dizziness. J Neurol 267(6):1864–1869
Cheung CS, Mak PS, Manley KV et al (2010) Predictors of important neurological causes of dizziness among patients presenting to the emergency department. Emerg Med J 27(7):517–521
Renner V, Geissler K, Boeger D et al (2017) Inpatient treatment of patients admitted for dizziness: a population-based healthcare research study on epidemiology, diagnosis, treatment, and outcome. Otol Neurotol 38(10):e460–e469
Navi B, Kamel H, Shah M et al (2012) Rate and predictors of serious neurologic causes of dizziness in the emergency department. Mayo Clin Proc 87(11):1080–1088
Kerber K, Zahuranec D, Brown D et al (2014) Stroke risk after nonstroke emergency department dizziness presentations: a population-based cohort study. Ann Neurol 75(6):899–907
Newman-Toker DE (2016) Missed stroke in acute vertigo and dizziness: it is time for action, not debate. Ann Neurol 79(1):27–31
Paul NL, Simoni M, Rothwell PM et al (2013) Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study. Lancet Neurol 12(1):65–71
Flossmann E, Rothwell PM (2003) Prognosis of vertebrobasilar transient ischaemic attack and minor stroke. Brain 126(Pt 9):1940–1954
Asdaghi N, Coutts S (2011) Stroke: neuroimaging in acute stroke-where does MRI fit in? Nat Rev Neurol 7(1):6–7
Saber Tehrani AS, Kattah JC, Kerber KA et al (2018) Diagnosing stroke in acute dizziness and vertigo: pitfalls and pearls. Stroke 49(3):788–795
Navi BB, Kamel H, Shah MP et al (2012) Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department. Stroke 43(6):1484–1489
Newman-Toker DE, Kerber KA, Hsieh YH et al (2013) HINTS outperforms ABCD2 to screen for stroke in acute continuous vertigo and dizziness. Acad Emerg Med 20(10):986–996
Kartal AG, Yilmaz S, Yaka E et al (2014) Diagnostic value of S100B protein in the differential diagnosis of acute vertigo in the emergency department. Acad Emerg Med 21(7):736–741
Kuroda R, Nakada T, Ojima T et al (2017) The TriAGe + score for vertigo or dizziness: a diagnostic model for stroke in the emergency department. J Stroke Cerebrovasc Dis 26(5):1144–1153
Herrington W, Lacey B, Sherliker P et al (2016) Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease. Circ Res 118(4):535–546
Vilar R, Fish R, Casini A et al (2020) Fibrin(ogen) in human disease: both friend and foe. Haematologica 105(2):284–296
Kokotailo R, Hill M (2005) Coding of stroke and stroke risk factors using international classification of diseases, revisions 9 and 10. Stroke 36(8):1776–1781
Burt C, Schappert S (2004) Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1999-2000. Vital and health statistics Series 13 undefined (157):1–70
Kerber K, Brown D, Lisabeth L et al (2006) Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke 37(10):2484–2487
Atzema CL, Grewal K, Lu H et al (2016) Outcomes among patients discharged from the emergency department with a diagnosis of peripheral vertigo. Ann Neurol 79(1):32–41
Tao WD, Liu M, Fisher M et al (2012) Posterior versus anterior circulation infarction: how different are the neurological deficits? Stroke 43(8):2060–2065
Ohle R, Montpellier R‐A, Marchadier V et al (2020) Can emergency physicians accurately rule out a central cause of vertigo using the HINTS examination? A systematic review and meta‐analysis. Acad Emerg Med 27(9):887–896. https://doi.org/10.1111/acem.13960
Saber Tehrani AS, Coughlan D, Hsieh YH et al (2013) Rising annual costs of dizziness presentations to U.S. emergency departments. Acad Emerg Med 20(7):689–696
Shenhar-Tsarfaty S, Ben Assayag E, Bova I et al (2008) Persistent hyperfibrinogenemia in acute ischemic stroke / transient ischemic attack (TIA). Thromb Haemost 99(1):169–173
Alvarez-Perez F, Castelo-Branco M, Alvarez-Sabin J (2011) Usefulness of measurement of fibrinogen, D-dimer, D-dimer/fibrinogen ratio, C reactive protein and erythrocyte sedimentation rate to assess the pathophysiology and mechanism of ischaemic stroke. J Neurol Neurosurg Psychiatry 82(9):986–992
Grotemeyer K (1990) Abnormal hemorheological parameters in vertebrobasilar-insufficiency. Acta Neurol Scand 81(6):529–532
Chuang SY, Bai CH, Chen WH et al (2009) Fibrinogen independently predicts the development of ischemic stroke in a Taiwanese population: CVDFACTS study. Stroke 40(5):1578–1584
Smith S, Travers R, Morrissey J (2015) How it all starts: Initiation of the clotting cascade. Crit Rev Biochem Mol Biol 50(4):326–336
Sabeti S, Exner M, Mlekusch W et al (2005) Prognostic impact of fibrinogen in carotid atherosclerosis: nonspecific indicator of inflammation or independent predictor of disease progression? Stroke 36(7):1400–1404
Kofoed S, Wittrup H, Sillesen H et al (2003) Fibrinogen predicts ischaemic stroke and advanced atherosclerosis but not echolucent, rupture-prone carotid plaques: the Copenhagen City Heart Study. Eur Heart J 24(6):567–576
Zhang Y, Zhu C, Guo Y et al (2014) Higher fibrinogen level is independently linked with the presence and severity of new-onset coronary atherosclerosis among Han Chinese population. PloS One 9(11):e113460
Mauriello A, Sangiorgi G, Palmieri G et al (2000) Hyperfibrinogenemia is associated with specific histocytological composition and complications of atherosclerotic carotid plaques in patients affected by transient ischemic attacks. Circulation 101(7):744–750
Walton BL, Byrnes JR, Wolberg AS (2015) Fibrinogen, red blood cells, and factor XIII in venous thrombosis. J Thromb Haemost 13:S208–S215. https://doi.org/10.1111/jth.12918
Fatah K, Hamsten A, Blombäck B et al (1992) Fibrin gel network characteristics and coronary heart disease: relations to plasma fibrinogen concentration, acute phase protein, serum lipoproteins and coronary atherosclerosis. Thromb Haemost 68(2):130–135
Guo F, Liu J, Wang C et al (2009) Fibrinogen, fibrin, and FDP induce C-reactive protein generation in rat vascular smooth muscle cells: pro-inflammatory effect on atherosclerosis. Biochem Biophys Res Commun 390(3):942–946
Eidelman R, Hennekens C (2003) Fibrinogen: a predictor of stroke and marker of atherosclerosis. Eur Heart J 24(6):499–500
Willeit P, Thompson S, Agewall S et al (2016) Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration. Eur J Prev Cardiol 23(2):194–205
Kim H, Oh E, Choi S et al (2021) Transient vestibular symptoms preceding posterior circulation stroke: a prospective multicenter study. Stroke 52(6):e224–e228.
Lee C, Su Y, Ho H et al (2011) Risk of stroke in patients hospitalized for isolated vertigo: a four-year follow-up study. Stroke 42(1):48–52
Liu S, Wu N, Shi H et al (2020) Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease. Cardiovasc Diabetol 19(1):36
Poznyak Anastasia, Grechko Andrey V, Poggio Paolo, Myasoedova Veronika A, Alfieri Valentina, Orekhov Alexander N (2020) The diabetes mellitus–atherosclerosis connection: the role of lipid and glucose metabolism and chronic inflammation. Int J Mol Sci 21(5):1835. https://doi.org/10.3390/ijms21051835
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent
Considering the study was retrospective, the informed consent requirement was waived by the ethics committee of the hospital.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Wang, Y., Zhou, X. & Luo, Y. Predicting value of fibrinogen in identifying cerebrovascular ischemic events in patients with dizziness/vertigo. Neurol Sci 43, 1105–1113 (2022). https://doi.org/10.1007/s10072-021-05363-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-021-05363-3