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Sleep duration and efficiency are associated with plasma amyloid-β in non-demented older people

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A Correction to this article was published on 06 January 2022

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Abstract

Study objectives

This study aims to investigate the extent to which sleep duration and efficiency are associated with plasma amyloid-β (Aβ) levels in non-demented older people.

Methods

This study is a cross-sectional analysis of 305 non-demented older people. Sleep duration and efficiency were assessed used the Pittsburgh Sleep Quality Index. Levels of plasma Aβ were determined by sandwich enzyme-linked immunosorbent assay technique. Associations between sleep variables and plasma Aβ levels were evaluated with multivariable linear regression analysis.

Results

Compared to those with sleep duration > 7 h, participants with sleep duration < 6 h had a higher plasma Aβ42 level (β = 0.495, 95% CI 0.077~0.913, p = 0.021) and Aβ42/Aβ40 ratio (β = 0.101, 95% CI 0.058~0.144, p < 0.001). Compared to those with sleep efficiency ≥ 85%, participants with lower sleep efficiency (65~74%, <65%) had a higher level of plasma Aβ42 (<65%: β = 0.627, 95% CI 0.147~1.108, p = 0.011) and Aβ42/Aβ40 ratio (65~74%: β = 0.052, 95% CI 0.007~0.097, p = 0.026; <65%: β = 0.117, 95% CI 0.067~0.168, p < 0.001).

Conclusions

These findings indicated that short sleep duration and low sleep efficiency were associated with a high level of Aβ42. A better comprehending of the link between sleep and plasma Aβ levels may lead to effective sleep-based intervention to reduce the risk of Alzheimer’s disease.

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Acknowledgements

We would like to thank Ms. Weiping Zhang and Ms. Biqing Lin for the screening tests in our clinic population. We thank Ms. Qiulan Huang for assistance in data collection and recruitment.

Funding

This work was supported by the National Key R&D Program of China (Grant No. 2018YFC2001700), the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (Grant No. 2015BAI06B02), and the Special fund of Foshan Summit plan (Grant No. 2019A011).

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Authors and Affiliations

  1. Department of Neurology, First People’s Hospital of Foshan, No.81, Lingnan North Road, Foshan, 528000, Guangdong, China

    Yajing Liu, Lushi Chen, Shuyun Huang, Lang Hu, Jiali Luo, Pan Shang, Yukai Wang & Haiqun Xie

  2. National Research Center for Rehabilitation Technical Aids, Rehabilitation Hospital, Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, Key Laboratory of Intelligent Control and Rehabilitation Technology of the Ministry of Civil Affairs, Beijing, China

    Zeping Lv

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  1. Yajing Liu
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  2. Lushi Chen
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Correspondence to Yukai Wang or Haiqun Xie.

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The authors declare no competing interests.

Ethical approval

This study was approved by First People’s Hospital of Foshan Research Ethics Board. The participants provided their written informed consent to participate in this study.

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Yajing Liu and Lushi Chen are co-first authors.

The original online version of this article was revised: Originally, a number 7 was added in the article title of the article. We have corrected and removed the added data here.

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Liu, Y., Chen, L., Huang, S. et al. Sleep duration and efficiency are associated with plasma amyloid-β in non-demented older people. Neurol Sci 43, 305–311 (2022). https://doi.org/10.1007/s10072-021-05271-6

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