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Migraine neuroscience: from experimental models to target therapy

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Abstract

Migraine sciences have witnessed tremendous advances in recent years. Pre-clinical and clinical experimental models have contributed significantly to provide useful insights into the brain structures that mediate migraine attacks. These models have contributed to elucidate the role of neurotransmission pathways and to identify the role of important molecules within the complex network involved in migraine pathogenesis. The contribution and efforts of several research groups from all over the world has ultimately lead to the generation of novel therapeutic approaches, specifically targeted for the prevention of migraine attacks, the monoclonal antibodies directed against calcitonin gene-related peptide or its receptor. These drugs have been validated in randomized placebo-controlled trials and are now ready to improve the lives of a large multitude of migraine sufferers. Others are in the pipeline and will soon be available.

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Funding

This manuscript was partly supported by grants from the Italian Ministry of Health to IRCCS Mondino 432 Foundation, Pavia, Italy (GR-2016-02363848, and RC2017-2019).

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Authors and Affiliations

  1. Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy

    Rosaria Greco, Chiara Demartini, Roberto De Icco, Daniele Martinelli, Alessia Putortì & Cristina Tassorelli

  2. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

    Roberto De Icco, Daniele Martinelli, Alessia Putortì & Cristina Tassorelli

Authors
  1. Rosaria Greco
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  2. Chiara Demartini
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  3. Roberto De Icco
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  4. Daniele Martinelli
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  5. Alessia Putortì
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  6. Cristina Tassorelli
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Correspondence to Rosaria Greco.

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Conflict of interest

CT received honoraria for the participation to advisory boards or for oral presentations from 424 Allergan, ElectroCore, Eli-Lilly, Novartis, and Teva. CT has no ownership interest and does not 425 own stocks of any pharmaceutical company. CT serves as Chief Section Editor of Frontiers in 426 Neurology—Section Headache Medicine and Facial Pain and on the editorial board of The Journal of Headache and Pain.

The other authors have no potential conflicts of interest to declare.

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Greco, R., Demartini, C., De Icco, R. et al. Migraine neuroscience: from experimental models to target therapy. Neurol Sci 41 (Suppl 2), 351–361 (2020). https://doi.org/10.1007/s10072-020-04808-5

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