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Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review

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Abstract

Multiple sclerosis (MS) as chronic autoimmune inflammatory neurological disease of the central nervous system (CNS) occurs due to several environmental and genetic factors, whose pathogenesis is associated with genes with regulatory role in the immune system. Long non-coding RNAs (LncRNAs) are able to reportedly regulate responses of immune systems and expression of genes, and show the tissue specificity and complexity of biofunctions. Various studies have suggested that the aberrant LncRNA expression is an underlying factor involved in the incidence of MS and that the analysis of the expression profile of these molecules can be a specific biomarker of MS for preventing the course of the disease or responding to treatment. The purpose of this research was to review the recent studies for exploring the functions of LncRNAs in the processes leading to MS disease.

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Acknowledgments

The authors would like to thank all colleagues in the Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences.

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All authors listed have made a substantial, direct, and intellectual contribution to the work, and approved it for publication.

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

    Eskandar Taghizadeh

  2. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Eskandar Taghizadeh, Mohammad Mahdi Samadian & Mohammad Soudyab

  3. Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

    Forough Taheri

  4. Department of Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Abbas Abi

  5. Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Seyed Mohammad Gheibi hayat

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  1. Eskandar Taghizadeh
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Taghizadeh, E., Taheri, F., Samadian, M.M. et al. Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review. Neurol Sci 41, 2443–2451 (2020). https://doi.org/10.1007/s10072-020-04425-2

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