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Spectral domain OCT can differentiate the retinal morphological changes of patients with Parkinson’s disease in clinical middle stages

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Abstract

Background

The retinal morphological change has been detected in Parkinson’s disease. However, the previous studies had a controversial conclusion. The aim of this study was to observe the changes of retinal morphology in patients with Parkinson’s disease with different clinical stages based on Hoehn-Yahr stage by spectral domain optical coherence tomography (SD-OCT).

Method

Fifty-three PD patients and forty-one healthy controls (HC) were enrolled. Subjects were assessed for the retinal structure using SD-OCT and general ophthalmic examinations. The PD group was divided into three subgroups by the Hoehn and Yahr scale: H-Y I stage group, H-Y II stage group, and H-Y III stage group.

Results

The mean deviation of visual field had a significant difference among the four groups. The macular retinal thickness (MRT) and macular volume (MV) were obviously decreased in PD patients. And the further statistical analysis showed that the difference appeared between the H-Y III stage group and HC group. The other subgroups had no differences compared with the HC group.

Conclusion

SD-OCT examination can detect the changes in retinal morphology in PD patients, and it may not be found the difference until the patients are in the H-Y III stage (the middle stage of PD).

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Acknowledgments

The authors are grateful to the patients with Parkinson’s disease and the healthy people enrolled for their participation in this research.

Funding

This work was supported by the Suzhou Science and Technology Development Project (SYSD2016091), National Natural Science Foundation of China (No. 81671270), Project of Clinical Advantage Scientific Group of the Second Affiliated Hospital of Soochow University (XKQ2015002), and the Nature Science Foundation of Jiangsu Province (BK20161220).

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Authors and Affiliations

  1. Department of Ophthalmology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

    Jiang Huang, Guoxu Xu, Ji Zhang & Tongtong Niu

  2. Department of Ophthalmology, Huashan Hospital North, Fudan University, Shanghai, China

    Qingping Wang

  3. Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

    Kai Li, Jing Liu, Qilin Zhang & Weifeng Luo

  4. Department of Neurology, Changsha Central Hospital, Changsha, China

    Qin Zhang

Authors
  1. Jiang Huang
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  2. Qingping Wang
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  3. Kai Li
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  4. Qin Zhang
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  5. Guoxu Xu
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  6. Jing Liu
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  7. Ji Zhang
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  8. Tongtong Niu
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  9. Qilin Zhang
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  10. Weifeng Luo
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Corresponding author

Correspondence to Weifeng Luo.

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Huang, J., Wang, Q., Li, K. et al. Spectral domain OCT can differentiate the retinal morphological changes of patients with Parkinson’s disease in clinical middle stages. Neurol Sci 41, 1909–1912 (2020). https://doi.org/10.1007/s10072-020-04266-z

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  • DOI: https://doi.org/10.1007/s10072-020-04266-z

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