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Correlation between EEG during AED withdrawal and epilepsy recurrence: a meta-analysis

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Abstract

To assess the risk of epilepsy recurrence after withdrawal from antiepileptic drugs (AEDs), researchers extensively studied recurrence-related risk factors, including electroencephalogram (EEG) during AED withdrawal. The relationship between EEG and epilepsy recurrence is controversial. We used meta-analysis to determine the correlation between EEG during AED withdrawal and epilepsy recurrence. A total of seven studies met the criteria for inclusion. The Newcastle–Ottawa Scale was used to conduct the research quality evaluation. Seven hundred three patients were included in meta-analysis. Patients with abnormal EEGs during withdrawal had a higher recurrence rate than patients with normal EEGs. Abnormal EEGs during withdrawal were a risk factor for recurrence.

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Funding

This study was supported by the National Natural Science Foundation of China (grant number 81071040, 81471320).

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  1. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Juan Yao, Hao Wang & Zheng Xiao

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  1. Juan Yao
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  2. Hao Wang
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Correspondence to Zheng Xiao.

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Yao, J., Wang, H. & Xiao, Z. Correlation between EEG during AED withdrawal and epilepsy recurrence: a meta-analysis. Neurol Sci 40, 1637–1644 (2019). https://doi.org/10.1007/s10072-019-03855-x

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