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Association of variants in microRNA with Parkinson’s disease in Chinese Han population

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Abstract

MicroRNAs (miRNAs) are short RNAs regulating gene expression and may participate in pathogenesis of various diseases. Recently, rs897984:T > C in miR-4519 and rs11651671:A > G in miR-548at-5p have been reported that associate with Parkinson’s disease (PD). However, to our knowledge, there is no further evidence regarding this finding. Herein, we performed a case-control study of 546 PD patients and 550 healthy controls to genotype the two single-nucleotide polymorphisms (SNPs) to assess their associations with PD. The results showed that rs897984 (OR value for C allele = 0.851, 95% CI 0.603–1.201, P = 0.358) in miR-4519 and rs11651671 (OR value for G allele = 1.405, 95% CI 0.927–2.131, P = 0.107) in miR-548at-5p were not associated to PD, which suggest they may not contribute to the gene susceptibility of PD at least in Chinese Han population. More evidences from larger sample size and other ethnic populations are still needed to illustrate the association between miRNAs and PD.

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Acknowledgments

We acknowledge all the participants including both stroke patients and healthy controls.

Funding

This work was supported by National Key R&D Program of China [2017YFA0105000], the National Natural Science Foundation of China to Dr. Yuming Xu [grant numbers 81530037, 81471158], the National Natural Science Foundation of China to Dr. Changhe Shi [grant number 81771290], and National Natural Science Foundation of China to Dr. Han Liu [grant number 81701247].

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  1. Fang Li and Han Liu contributed equally to this article.

Authors and Affiliations

  1. Department of Neurology, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, 1 Jian-she east road, Zhengzhou, Henan, 450000, China

    Fang Li, Han Liu, Yuan Cheng, Jing Yang, Yutao Liu, Yanlin Wang, Zhihua Yang, Changhe Shi & Yuming Xu

  2. Institute of Clinical Medicine, The first affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450000, China

    Fang Li, Yuan Cheng & Zhihua Yang

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  1. Fang Li
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Correspondence to Changhe Shi or Yuming Xu.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Li, F., Liu, H., Cheng, Y. et al. Association of variants in microRNA with Parkinson’s disease in Chinese Han population. Neurol Sci 39, 353–357 (2018). https://doi.org/10.1007/s10072-017-3210-4

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