Neurological Sciences

, Volume 38, Supplement 1, pp 201–206 | Cite as

Transcutaneous supraorbital neurostimulation for the prevention of chronic migraine: a prospective, open-label preliminary trial

  • Paola Di FioreEmail author
  • Gennaro Bussone
  • Alberto Galli
  • Henri Didier
  • Cesare Peccarisi
  • Domenico D’Amico
  • Fabio Frediani


Since chronic migraine is difficult to treat and often associated with medication overuse, non-invasive neurostimulation approaches are worth investigating. Transcutaneous supraorbital neurostimulation using the Cefaly® device is promising as a non-invasive preventive treatment for episodic migraine, but no data are available for chronic migraine. Our aim was to perform a preliminary evaluation of the efficacy of the Cefaly® device for the prophylaxis of chronic migraine with or without medication overuse. Primary endpoints were 50% reduction in monthly migraine days and 50% reduction in monthly medication use over 4 months. In an open-label study, twenty-three consecutive headache center patients with chronic migraine, diagnosed according to International Headache Society criteria, were recruited prospectively. After informed consent, patients were trained to use Cefaly® and instructed to use it for 20 min daily over 4 months. All patients received active neurostimulation. Thirty-five percent of the patients enrolled in the study achieved the study endpoints. Over half the patients had a greater than 50% reduction in acute medication consumption.


Chronic migraine Migraine prophylaxis Medication overuse Transcutaneous supraorbital neurostimulation 


Compliance with ethical standards


This study had no external funding source. Cefaly® devices were made available by the manufacturer (Cefaly Technology, Liège, Belgium) free of charge, for use in the study, Cefaly® Technology had no role in the design or conduct of the study

Conflict of interest

The authors certify that there is no actual or potential conflict of interest in relation to this article.


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Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  • Paola Di Fiore
    • 1
    Email author
  • Gennaro Bussone
    • 2
  • Alberto Galli
    • 1
  • Henri Didier
    • 3
  • Cesare Peccarisi
    • 4
  • Domenico D’Amico
    • 5
  • Fabio Frediani
    • 1
  1. 1.Neurological and Stroke Unit Department, Headache Center, ASST Santi Paolo e CarloSan Carlo Borromeo HospitalMilanItaly
  2. 2.C. Besta Neurological Institute IRCCS Foundation and Igea Healthcare InstituteMilanItaly
  3. 3.Maxillo-Facial and Dental Unit, Dental and Oral Surgery, Headache and Facial Pain Center, IRCCS Foundation Ca’ Granda, Ospedale Maggiore PoliclinicoUniversity of MilanMilanItaly
  4. 4.LIMPE-DISMOV AcademyUniversity La SapienzaRomeItaly
  5. 5.Headache CenterCarlo Besta Neurological Institute and FoundationMilanItaly

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