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Gender differences on motor and non-motor symptoms of de novo patients with early Parkinson’s disease

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Abstract

The affect of gender differences on clinical presentation of Parkinson’s disease (PD) remains controversial. De novo PD subjects were recruited from a trial-based multicenter cohort in clinical sites of Chinese Parkinson Study Group. Demographic information, motor and non-motor symptom measurements were performed by face-to-face interview using specific scales. Scores and frequencies of symptoms were compared between male and female patients, and regression models were used to control the effects of age and disease duration. Totally 428 PD patients were enrolled in this study, and 60.3 % of them were male. Total UPDRS scores were not significantly different between male and female (25.02 ± 12.84 vs. 25.24 ± 13.22, adjusted p = 0.984). No significant gender differences were found on scores for four cardinal motor signs, neither on motor subtypes (PIGD 19.0 vs. 15.9 %, adjusted p = 0.303). Female patients more likely had depressive symptoms (38.8 vs. 27.5 %, adjusted p = 0.023; CES-D score 13.78 ± 10.91 vs. 11.23 ± 9.42, adjusted p = 0.015). Male patients had significantly higher scores for MMSE (28.26 ± 2.21 vs. 27.00 ± 3.38, adjusted p = 0.0001), and lower scores for identification (1.39 ± 1.63 vs. 2.01 ± 2.63, adjusted p = 0.002) in ADAS-cog. No significant differences were found for other non-motor symptoms including motivation problems (male 29.8 % vs. female 30.6 %, adjusted p = 0.760), fatigue (62.6 vs. 70.5 %, adjusted p = 0.140), constipation (37.2 vs. 30.1 %, adjusted p = 0.243), and sleep quality (57.6 vs. 61.3 %, adjusted p = 0.357; PSQI score: 5.62 ± 3.31 vs. 6.10 ± 3.53, adjusted p = 0.133). Female might be more depressed and have worse performance on cognition in early untreated PD patients, but gender differences are not apparent on motor and other non-motor symptoms.

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Acknowledgments

The study was supported by grants from the Ministry of Science and Technology of China (2012AA02A514), the National Basic Research Development Program of China (2011CB504101), Ministry of Health (201002011), and the Beijing High Standard Health Human Resource Cultural Program in Health System (2009e1e12).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Neurology and Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 10053, China

    Yang Song, Jing An & Piu Chan

  2. Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China

    Jing An & Piu Chan

  3. Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing, China

    Jing An & Piu Chan

  4. Key Laboratory on Parkinson Disease of Beijing, Beijing, China

    Jing An & Piu Chan

  5. Chinese National Human Genome Center, Beijing, China

    Zhuqin Gu & Piu Chan

Authors
  1. Yang Song
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  2. Zhuqin Gu
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  4. Piu Chan
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Consortia

Chinese Parkinson Study Group

Corresponding author

Correspondence to Piu Chan.

Additional information

The members of Chinese Parkinson Study Group are listed in Appendix.

Appendix: Members of Chinese Parkinson Study Group (CPSG)

Appendix: Members of Chinese Parkinson Study Group (CPSG)

Piu Chan (Xuanwu Hospital of Capital Medical University), Yanming Xu (West China Hospital of Sichuang University), Jun Xu (The Affiliated Gulou Hospital of Nanjing University), Yuming Xu (The First Affiliated Hospital of Zhengzhou University), Chunfeng Liu (The Second Affiliated Hospital of Suzhou University), Zhenyu Wang (The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine), Ping Wang (The Inner Mongolian People’s Hospital), Guohua Hu (The Second Affiliated Hospital of Jilin University), Weizhi Wang (The Second Affiliated Hospital of Harbin University), Baorong Zhang (The Second Affiliated Hospital of Zhejiang University), Zhanhua Liang (The First Affiliated Hospital of Dalian University), Anmu Xie (The Affiliated Hospital of Qindao University), Shengdi Chen (The Affiliated Ruijin Hospital of Shanghai Jiaotong University), Beisha Tang (Xiangya Hospital of Central Southern University), Benyan Luo (The First Affiliated Hospital of Zhejiang University), Wen Lü (The Affiliated Sir Sun Yat-Sen Hospital of Zhejiang University), Shenggang Sun (The Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology), Ming Shao (The First Affiliated Hospital of Guanzhou Medical College), Tao Feng (The Affiliated Tiantan Hospital of Capital Medical University), Zhuolin Liu (The First Hospital of Sun Yat-Sen University), Yiming Liu (Qilu Hospital of Shangdong University), Qinyong Ye (The Affiliated Union University of Fujian Medical University), Haibo Chen (Beijing Hospital), Xinhua Wan (Peking Union Medical College Hospital), Xia Sheng (The Affiliated Hospital of Xuzhou Medical College).

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Song, Y., Gu, Z., An, J. et al. Gender differences on motor and non-motor symptoms of de novo patients with early Parkinson’s disease. Neurol Sci 35, 1991–1996 (2014). https://doi.org/10.1007/s10072-014-1879-1

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  • DOI: https://doi.org/10.1007/s10072-014-1879-1

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