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Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury

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Abstract

Traumatic brain injury (TBI) is a leading cause of mortality and disability in children and young adults worldwide. Neurologic impairment is caused by both immediate brain tissue disruption and post-injury cellular and molecular events that worsen the primary neurologic insult. The β-lactam antibiotic ceftriaxone (CTX) has been reported to induce neuroprotection in animal models of diverse neurologic diseases via up-regulation of GLT-1. However, no studies have addressed the neuroprotective role of CTX in the setting of TBI, and whether the mechanism is involved in the modulation of neuronal autophagy remains totally unclear. The present study was designed to determine the hypothesis that administration of CTX could significantly enhance functional recovery in a rat model of TBI and whether CTX treatment could up-regulate GLT-1 expression and suppress post-TBI neuronal autophagy. The results demonstrated that daily treatment with CTX attenuated TBI-induced brain edema and cognitive function deficits in rats. GLT-1 is down-regulated following TBI and this phenomenon can be reversed by treatment of CTX. In addition, we also found that CTX significantly reduced autophagy marker protein, LC3 II, in hippocampus compared to the TBI group. These results suggest that CTX might provide a new therapeutic strategy for TBI and this protection might be associated with up-regulation of GLT-1 and suppression of neuronal autophagy.

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Acknowledgments

This research was supported by the Natural Science Foundation of Hebei, China, Grant Number H2012401071.

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Authors and Affiliations

  1. Department of Surgery, Hebei Medical University, No. 361 East Zhongshan Road, Shijiazhuang, 050017, People’s Republic of China

    Changmeng Cui & Jianzhong Cui

  2. Tangshan Workers’ Hospital, Tangshan, 063000, People’s Republic of China

    Ying Cui, Liqian Sun, Kaijie Wang & Jianzhong Cui

  3. School of Basic Medical Science, Hebei United University, Tangshan, 063000, People’s Republic of China

    Junling Gao, Yongchao Wang, Ran Li & Yanxia Tian

  4. Department of Neurosurgery, Affiliated Hospital of Taishan Medical University, Taishan, 271000, People’s Republic of China

    Sixin Song

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  1. Changmeng Cui
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  2. Ying Cui
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  4. Liqian Sun
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  7. Ran Li
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  9. Sixin Song
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  10. Jianzhong Cui
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Correspondence to Changmeng Cui.

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Cui, C., Cui, Y., Gao, J. et al. Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury. Neurol Sci 35, 695–700 (2014). https://doi.org/10.1007/s10072-013-1585-4

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  • DOI: https://doi.org/10.1007/s10072-013-1585-4

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