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Association of monocyte chemoattractant protein-1 −2518A>G polymorphism with occurrence, severity, and outcome in ischemic stroke

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Abstract

Monocyte chemoattractant protein-1 (MCP-1) is implicated in promoting atherosclerotic diseases, including stroke. Therefore, several studies have investigated the association between variants of the MCP-1 gene and risk of atherosclerotic diseases. We sought to determine the occurrence of MCP-1 −2518A>G polymorphism in patients with ischemic stroke (IS), and studied its association with the severity of disease and functional outcome after an acute IS. One hundred and forty-five consecutive patients with first ever IS and 145 age- and sex-matched control subjects were recruited. Stroke severity and functional outcome were assessed on admission and at one month post-stroke, respectively. Genotyping for the MCP-1 −2518A>G polymorphism was performed by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). No significant difference in the frequency of MCP-1 −2518A>G genotypes between IS patients and controls was found, with OR = 0.69 (95 % CI 0.46–1.04, P = 0.08). Moreover, carriage of the G allele was not associated with stroke severity (Scandinavian stroke scale score 33.1 vs. 32.5, respectively, P = 0.71), or poor outcome at 1 month post-stroke (63.9 vs. 59.7 %, respectively, P = 0.61). In conclusion, we were unable to demonstrate a significant association of the MCP-1 −2518A>G gene polymorphism with IS occurrence, severity or functional outcome in a Caucasian population. However, larger studies are necessary to fully elucidate the role of this polymorphism in IS.

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Authors and Affiliations

  1. Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100, Alexandroupolis, Greece

    Efstathia Giannakopoulou, Georgia Ragia, Vangelis G. Manolopoulos & Anna Tavridou

  2. Department of Neurology, University of Patras, Patras, Greece

    Stella Marousi & John Ellul

Authors
  1. Efstathia Giannakopoulou
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  2. Georgia Ragia
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  3. Stella Marousi
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  4. John Ellul
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  5. Vangelis G. Manolopoulos
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  6. Anna Tavridou
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Correspondence to Anna Tavridou.

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Giannakopoulou, E., Ragia, G., Marousi, S. et al. Association of monocyte chemoattractant protein-1 −2518A>G polymorphism with occurrence, severity, and outcome in ischemic stroke. Neurol Sci 34, 1315–1320 (2013). https://doi.org/10.1007/s10072-012-1235-2

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  • DOI: https://doi.org/10.1007/s10072-012-1235-2

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