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Headache therapy with neuronal stabilising drugs

  • Current Reality in Headache Treatments
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Abstract

Migraine is a frequent episodic condition that often requires prophylaxis treatment to reduce the severity, frequency and duration of attacks and to ameliorate disability. Migraine can be interpreted as a disorder of pain modulation, which involves the trigeminovascular system and central nervous system modulation of paincontrolling structures. Antiepileptic drugs (neuronal stabilising drugs, NSD) have been increasingly recommended for migraine prophylaxis because of several well conducted studies confirming their efficacy. Valproate, Topiramate and Gabapentin are indicated as useful drugs for migraine preventive therapy according to the results of randomised double-blind, placebo-controlled trials. Due to these positive results, neuronal stabilisation may be considered as a pivotal approach for headache therapy.

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Authors and Affiliations

  1. Department of Neurology Headache Research Unit, IRCCS San Raffaele University Vita-Salute, Via Olgettina 48, 20100, Milan, Italy

    Bruno Colombo, Dacia Dalla Libera, Pietro Oreste Annovazzi & Giancarlo Comi

Authors
  1. Bruno Colombo
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  2. Dacia Dalla Libera
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  3. Pietro Oreste Annovazzi
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  4. Giancarlo Comi
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Correspondence to Bruno Colombo.

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Colombo, B., Dalla Libera, D., Annovazzi, P.O. et al. Headache therapy with neuronal stabilising drugs. Neurol Sci 29 (Suppl 1), 131–136 (2008). https://doi.org/10.1007/s10072-008-0904-7

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  • DOI: https://doi.org/10.1007/s10072-008-0904-7

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