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The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives

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Abstract

The significance of gut microbiome and their metabolites (postbiotics) on human health could be a promising approach to treat various diseases that includes inflammatory bowel diseases, colon cancer, and many neurological disorders. Probiotics with potential mental health benefits (psychobiotics) can alter the gut-brain axis via immunological, humoral, neuronal, and metabolic pathways. Recently, probiotic bacteria like Lactobacillus and Bifidobacterium have been demonstrated for SCFAs production, which play a crucial role in a variety of diseases. These acids could enhance the production of mucins, antimicrobial proteins (bacteriocins and peptides), cytokines (Interleukin 10 and 18) and neurotransmitters (serotonin) in the intestine to main the gut microbiota, intestinal barrier system and other immune functions. In this review, we discuss about two mechanisms such as (i) SCFAs mediated intestinal barrier system, and (ii) SCFAs mediated gut-brain axis to elucidate the therapeutic options for the treatment/prevention of various diseases.

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Authors are thankful to School of Life Sciences, BSACIST, Chennai, Tamil Nadu, India for providing all the facilities while collecting the experimental work. Manuscript do not receive any fund.

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    Mangala Lakshmi Ragavan & S. Hemalatha

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Ragavan, M.L., Hemalatha, S. The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives. Food Sci Biotechnol 33, 275–285 (2024). https://doi.org/10.1007/s10068-023-01414-x

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