Skip to main content
SpringerLink
Log in

Recent advancement in ultrasound-assisted novel technologies for the extraction of bioactive compounds from herbal plants: a review

  • Review
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

Herbal plants comprise potent bioactives, and they have a potential for the development of functional foods. Ultrasonication technology can be used to enhance the efficiency and quality of these bioactivities. The present review discussed the ultrasound-assisted novel extraction technologies (supercritical carbon dioxide (CO2) and high pressurized liquid), including mechanistic understanding, influencing factors, extract process efficiency, and the recovery of bioactives with an industrial perspective. The strong observations of this study are the novel ultrasound-induced extraction process variables, such as ultrasound amplitude, sonication time, temperature, solid-solvent ratio, and pressure, are significantly influenced and must be optimized for maximum recovery of bioactives. The novel green technologies (ultrasound and assisted) could remarkably improve the extraction efficiency and enhance the quality of green extract. This review will support technological understanding about the impact on process parameters for the extraction of bioactives for the development of functional foods and nutraceuticals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Aguilar-Hernández G, Zepeda-Vallejo LG, García-Magaña MDL, Vivar-Vera MDLÁ, Pérez-Larios A, Girón-Pérez MI, Montalvo-González E. Extraction of alkaloids using ultrasound from pulp and by-products of soursop fruit (Annona muricata L.). Applied Sciences. 10(14): 4869 (2020) https://doi.org/10.3390/app10144869

    Article  CAS  Google Scholar 

  • Albero B, Tadeo JL, Pérez RA. Ultrasound-assisted extraction of organic contaminants. Trends in Analytical Chemistry. 118: 739-750 (2019)

    Article  CAS  Google Scholar 

  • Almusallam IA, Mohamed Ahmed IA, Babiker EE, Al Juhaimi FY, Fadimu GJ, Osman MA, Al Maiman SA, Ghafoor K, Alqah HAS, Optimization of ultrasound-assisted extraction of bioactive properties from date palm (Phoenix dactylifera L.) spikelets using response surface methodology. LWT-Food Science and Technology. 140(December 2020): 110816 (2021) https://doi.org/10.1016/j.lwt.2020.110816

    Article  CAS  Google Scholar 

  • Altemimi A, Lightfoot DA, Kinsel M, Watson DG. Employing response surface methodology for the optimization of ultrasound assisted extraction of lutein and β-carotene from spinach. Molecules. 20(4): 6611-6625. (2015) https://doi.org/10.3390/molecules20046611

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Amin R, Ahmed D, Aydar AY, Qamar MT. Modelling of polyphenol and flavonoid extraction from bottle gourd fruit using green and cost effective LTTM glycerol-ammonium acetate in neat and diluted forms. Journal of Food Measurement and Characterization. 16(5): 3372–3384 (2022)

    Article  Google Scholar 

  • Aydar AY, Aydın T, Yılmaz T, Kothakota A, Terezia SC, Leontin CF, Pandiselvam R. Investigation on the influence of ultrasonic pretreatment on color, quality and antioxidant attributes of microwave dried Inula viscosa (L.). Ultrasonics Sonochemistry. 90: 106184 (2022)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Azimi Mahalleh A, Sharayei P, Azarpazhooh E. Optimization of ultrasonic-assisted extraction of bioactive compounds from Nepeta (Nepeta binaludensis Jamzad). Journal of Food Measurement and Characterization. 14(2): 668-678 (2020)

    Article  Google Scholar 

  • Bakht MA, Geesi MH, Riadi Y, Imran M, Ali MI, Ahsan MJ, Ajmal N. Ultrasound-assisted extraction of some branded tea: Optimization based on polyphenol content, antioxidant potential and thermodynamic study. Saudi Journal of Biological Sciences. 26(5): 1043-1052 (2019) https://doi.org/10.1016/j.sjbs.2018.07.013

    Article  CAS  Google Scholar 

  • Bernardi S, Lupatini-Menegotto AL, Kalschne DL, Moraes Flores ÉL, Bittencourt PRS, Colla E, Canan C. Ultrasound: A suitable technology to improve the extraction and techno-functional properties of vegetable food proteins. Plant Foods for Human Nutrition. 76: 1-11 (2021)

    Article  CAS  PubMed  Google Scholar 

  • Bhuyan P. Extraction of Neem ( Azadirachta Indica ) oil using blends of hexane , ethyl acetate and acetone by sonication. International Journal of Advance Research, Idras and Innovations in Technology. 5(2): 78-84 (2019)

    Google Scholar 

  • Bhuyan DJ, Vuong QV, Chalmers AC, Altena IA, Van Bowyer MC, Scarlett CJ. Phytochemical, antibacterial and antifungal properties of an aqueous extract of Eucalyptus microcorys leaves. South African Journal of Botany. 112: 180-185. (2017) https://doi.org/10.1016/j.sajb.2017.05.030

    Article  CAS  Google Scholar 

  • Chanioti S, Tzia C. Optimization of ultrasound-assisted extraction of oil from olive pomace using response surface technology: Oil recovery, unsaponifiable matter, total phenol content and antioxidant activity. LWT - Food Science and Technology. 79: 178-189 (2018) https://doi.org/10.1016/j.lwt.2017.01.029

    Article  CAS  Google Scholar 

  • Chatterjee T, Ghosh B. Micropropagation of medicinal plants: a review. International Journal of Economic Plants. 7(2): 066-072 (2020)

    Article  Google Scholar 

  • Chemat F, Vian MA, Cravotto G. Green extraction of natural products: Concept and principles. International Journal of Molecular Sciences. 13(7): 8615-8627. (2012) https://doi.org/10.3390/ijms13078615

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chemat F, Rombaut N, Meullemiestre A, Turk M, Perino S, Abert-vian M. Review of Green Food Processing techniques. Preservation, transformation, and extraction. Innovative Food Science and Emerging Technologies. 41(April): 357-377. (2017) https://doi.org/10.1016/j.ifset.2017.04.016

    Article  CAS  Google Scholar 

  • Chemat F, Rombaut N, Sicaire AG, Meullemiestre A, Fabiano-Tixier AS, Abert-Vian M. Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols, and applications. A review. Ultrasonics Sonochemistry. 34: 540–560 (2017) https://doi.org/10.1016/j.ultsonch.2016.06.035

    Article  CAS  PubMed  Google Scholar 

  • Čižmek L, Bavcon Kralj M, Čož-Rakovac R, Mazur D, Ul’yanovskii N, Likon M, Trebše P. Supercritical carbon dioxide extraction of four medicinal mediterranean plants: Investigation of chemical composition and antioxidant activity. Molecules. 26(18): 5697 (2021)

    Article  PubMed  PubMed Central  Google Scholar 

  • Dary C, Baghdikian B, Kim S, Mabrouki F, Hul S, Jabbour F, Bun SS. Optimization of ultrasound-assisted extraction of bioactive alkaloids from Stephania cambodica using response surface methodology. Comptes Rendus Chimie. 20(11-12): 996-1005 (2017) https://doi.org/10.1016/j.crci.2017.09.004

    Article  CAS  Google Scholar 

  • Dash DR, Pathak SS, Pradhan RC. Improvement in novel ultrasound-assisted extraction technology of high value-added components from fruit and vegetable peels. Journal of Food Process Engineering 44(4): e13658 (2021)

    Article  CAS  Google Scholar 

  • Dassoff ES, Li YO. Mechanisms and effects of ultrasound-assisted supercritical CO2 extraction. Trends in Food Science & Technology. 86: 492-501 (2019)

    Article  CAS  Google Scholar 

  • Deng Y, Wang W, Zhao S, Yang X, Xu W, Guo M, Liu D. Ultrasound-assisted extraction of lipids as food components: Mechanism, solvent, feedstock, quality evaluation and coupled technologies–A review. Trends in Food Science & Technology. (2022) https://doi.org/10.1016/j.tifs.2022.01.034

    Article  Google Scholar 

  • Dhanani T, Shah S, Gajbhiye NA, Kumar S. Effect of extraction methods on yield, phytochemical constituents and antioxidant activity of Withania somnifera. Arabian Journal of Chemistry. 10: S1193-S1199 (2017) https://doi.org/10.1016/j.arabjc.2013.02.015

    Article  CAS  Google Scholar 

  • Dias JL, Mazzutti S, de Souza JA, Ferreira SR, Soares LA, Stragevitch L, Danielski L. Extraction of umbu (Spondias tuberosa) seed oil using CO2, ultrasound and conventional methods: Evaluations of composition profiles and antioxidant activities. The Journal of Supercritical Fluids. 145, 10-18 (2019) https://doi.org/10.1016/j.supflu.2018.11.011

    Article  CAS  Google Scholar 

  • Dias ALB, de Aguiar AC, Rostagno MA. Extraction of natural products using supercritical fluids and pressurized liquids assisted by ultrasound: Current status and trends. Ultrasonics Sonochemistry. 74: 105584 (2021) https://doi.org/10.1016/j.ultsonch.2021.105584

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Do DT, Lam DH, Nguyen T, Phuong Mai TT, Phan LTM, Vuong HT, Nguyen DV, Linh NTT, Hoang MN, Mai TP, Nguyen HH. Utilization of response surface methodology in optimization of polysaccharides extraction from Vietnamese red Ganoderma lucidum by ultrasound-assisted enzymatic method and examination of bioactivities of the extract. Scientific World Journal. 2021: 1-14. (2021) https://doi.org/10.1155/2021/7594092

    Article  CAS  Google Scholar 

  • Dong Z, Delacour C, Carogher KM, Udepurkar AP, Kuhn S. Continuous ultrasonic reactors: Design, mechanism and application. Materials. 13(2): 344-358 (2020) https://doi.org/10.3390/ma13020344

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dzah CS, Duan Y, Zhang H, Wen C, Zhang J, Chen G, Ma H. The effects of ultrasound assisted extraction on yield, antioxidant, anticancer and antimicrobial activity of polyphenol extracts: A review. Food Bioscience. 35(June 2019): 100547 (2020) https://doi.org/10.1016/j.fbio.2020.100547

    Article  CAS  Google Scholar 

  • Fernando CD, Soysa P. Extraction Kinetics of phytochemicals and antioxidant activity during black tea (Camellia sinensis L.) brewing. Nutrition Journal. 14(1): 1-7 (2015) https://doi.org/10.1186/s12937-015-0060-x

    Article  CAS  Google Scholar 

  • Gavahian M, Manyatsi TS, Morata A, Tiwari BK. Ultrasound-assisted production of alcoholic beverages: From fermentation and sterilization to extraction and aging. Comprehensive Reviews in Food Science and Food Safety. 21(6): 5243–5271 (2022)

    Article  CAS  PubMed  Google Scholar 

  • Guo X, Shang X, Zhou X, Zhao B, Zhang J. Ultrasound-assisted extraction of polysaccharides from Rhododendron aganniphum: Antioxidant activity and rheological properties. Ultrasonics Sonochemistry. 38(3): 246-255 (2017) https://doi.org/10.1016/j.ultsonch.2017.03.021

    Article  CAS  PubMed  Google Scholar 

  • Hadidi M, Ibarz A, Pagan J. Optimisation and kinetic study of the ultrasonic-assisted extraction of total saponins from alfalfa (Medicago sativa) and its bioaccessibility using the response surface methodology. Food Chemistry. 309: 125786. (2020) https://doi.org/10.1016/j.foodchem.2019.125394

    Article  CAS  PubMed  Google Scholar 

  • He W, Yin M, Yang R, Zhao W. Optimization of adlay (Coix lacryma-jobi) bran oil extraction: Variability in fatty acids profile and fatty acid synthase inhibitory activities. Biocatalysis and Agricultural Biotechnology. 28: 101740 (2020) https://doi.org/10.1016/j.bcab.2020.101740

  • He Q, Lei Q, Huang S, Zhou Y, Liu Y, Zhou S, Qiu H. Effective extraction of bioactive alkaloids from the roots of Stephania tetrandra by deep eutectic solvents-based ultrasound-assisted extraction. Journal of Chromatography A. 1689: 463746 (2023)

  • Hojnik M, Škerget M, Knez Ž. Extraction of lutein from Marigold flower petals–Experimental kinetics and modelling. LWT-Food Science and Technology. 41(10) (2008) https://doi.org/10.1016/j.lwt.2007.11.017

    Article  Google Scholar 

  • Hsieh YH, Li Y, Pan Z, Chen Z, Lu J, Yuan J, Zhang J. Ultrasonication-assisted synthesis of alcohol-based deep eutectic solvents for extraction of active compounds from ginger. Ultrasonics Sonochemistry. 63: 104915 (2020) https://doi.org/10.1016/j.ultsonch.2019.104915

    Article  CAS  PubMed  Google Scholar 

  • Islam M, Saini P, Das R, Shekhar S, Sinha AS, Kumar M, Kamlesh P. Rice Straw as a Source of Nanocellulose for Sustainable Food Packaging Materials: A Review (pp. 2351–2385). Bipresources. (2023a) https://doi.org/10.15376/biores.18.1.Islam

    Article  Google Scholar 

  • Islam M, Malakar S, Dwivedi U, Kumar N, Prabakar PK, Kishore A, Kumar A. Impact of different drying techniques on grapefruit peels and subsequent optimization of ultrasonic extraction conditions for bioactive compounds. Journal of Food Process Engineering. e14331 (2023b) https://doi.org/10.1111/jfpe.14331

    Article  Google Scholar 

  • Jacotet-navarro M, Rombaut N, Fabiano-tixier A, Danguien M, Bily A, Chemat F. Ultrasound versus microwave as green processes for extraction of rosemarinic, carnosic and ursolic acids from rosemary. Ultrasonics Sonochemistry. 27: 102-109 (2015) https://doi.org/10.1016/j.ultsonch.2015.05.006

    Article  CAS  PubMed  Google Scholar 

  • Jamshaid S, Ahmed D. Optimization of ultrasound-assisted extraction of valuable compounds from fruit of Melia azedarach with glycerol-choline chloride deep eutectic solvent. Sustainable Chemistry and Pharmacy. 29: 100827 (2022)

    Article  CAS  Google Scholar 

  • Jamshaid S, Ahmed D, Aydar AY. Ultrasound-assisted extraction optimization of polyphenols, flavonoids, and antioxidant compounds from fruit of Melia azedarach using a glycerol-based green deep eutectic solvent. Journal of Food Processing and Preservation. 46(8): e16657 (2022)

    Article  CAS  Google Scholar 

  • Jiang Y, Ning Z, Li S. Extraction and purification of isochlorogenic acid C from Chrysanthemum morifolium using ionic liquid-based ultrasound-assisted extraction and aqueous two-phase system. Food Science & Nutrition. 6(8): 2113-2122 (2018)

    Article  CAS  Google Scholar 

  • Jin Y, Liu Z, Liu D, Shi G, Liu D, Yang Y, Gu H. Industrial Crops & Products Natural antioxidant of rosemary extract used as an additive in the ultrasound-assisted extraction of anthocyanins from lingonberry (Vaccinium vitis-idaea L.) pomace. Industrial Crops & Products. 138: 111425 (2019) https://doi.org/10.1016/j.indcrop.2019.05.074

    Article  CAS  Google Scholar 

  • Jiskani AH, Aydar AY, Ahmed D. Optimization of ultrasound-assisted extraction of antioxidant compounds from Rumex hastatus with response surface methodology. Journal of Food Processing and Preservation. 45(11): e15983 (2021)

    Article  CAS  Google Scholar 

  • Jovanović AA, Đorđević VB, Zdunić GM, Pljevljakušić DS, Šavikin KP, Gođevac DM, Bugarski BM. Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. Separation and Purification Technology. 179: 369-380. (2017) https://doi.org/10.1016/j.seppur.2017.01.055

    Article  CAS  Google Scholar 

  • Kate AE, Singh A, Shahi NC, Pandey JP, Singh TP,Prakash O. Impact of polar bio-solvent, particle size and soaking time on microwave-assisted extraction of edible oil from black soybean. Journal of Food Measurement and Characterization. 11(1): 272-280. (2018) https://doi.org/10.1007/s11694-016-9394-0

    Article  Google Scholar 

  • Khemakhem I, Ahmad-Qasem MH, Catalán EB, Micol V, García-Pérez JV, Ayadi MA, Bouaziz M. Kinetic improvement of olive leaves’ bioactive compounds extraction by using power ultrasound in a wide temperature range. Ultrasonics Sonochemistry. 34: 466-473. (2018) https://doi.org/10.1016/j.ultsonch.2016.06.010

    Article  CAS  Google Scholar 

  • Koubaa M, Mhemdi H, Fages J. Recovery of valuable components and inactivating microorganisms in the agro-food industry with ultrasound-assisted supercritical fluid technology. The Journal of Supercritical Fluids. 134: 71-79 (2018)

    Article  CAS  Google Scholar 

  • Kumar K, Srivastav S, Sharanagat VS. Ultrasound assisted extraction (UAE) of bioactive compounds from fruit and vegetable processing by-products: A review. Ultrasonics Sonochemistry. 70(2020): 105325 (2021) https://doi.org/10.1016/j.ultsonch.2020.105325

    Article  CAS  PubMed  Google Scholar 

  • Kumar G, Upadhyay S, Yadav DK, Malakar S, Dhurve P, Suri S. Application of ultrasound technology for extraction of color pigments from plant sources and their potential bio-functional properties: A review. Journal of Food Process Engineering. e14238 (2022) https://doi.org/10.1111/jfpe.14238

    Article  Google Scholar 

  • Kumar N, Kumar G, Prabhakar PK, Sahu JK, Naik S. Ultrasound-assisted extraction of bioactive compounds from giloy (Tinospora cordifolia) stem: Quantitative process optimization and bioactives analysis. Journal of Food Process Engineering. e14259 (2023) https://doi.org/10.1111/jfpe.14259

    Article  Google Scholar 

  • Kunene P, Mahlambi P. Assessment of antiretroviral drugs in vegetables: Evaluation of microwave-assisted extraction performance with and without solid-phase extraction cleanup. Separation Science Plus. 6(2): 2200059 (2023)

    Article  CAS  Google Scholar 

  • Li J, Chen Z, Shi H, Yu J, Huang G, Huang H. Ultrasound-assisted extraction and properties of polysaccharide from Ginkgo biloba leaves. Ultrasonics Sonochemistry. 106295 (2023) https://doi.org/10.1016/j.ultsonch.2023.106295

    Article  PubMed  PubMed Central  Google Scholar 

  • Liao J, Guo Z, Yu G. Process intensification and kinetic studies of ultrasound-assisted extraction of flavonoids from peanut shells. Ultrasonics Sonochemistry. 76: 105661 (2021) https://doi.org/10.1016/j.ultsonch.2021.105661

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu X, Ou H, Xiang Z, Gregersen H. Ultrasound pretreatment combined with supercritical CO2 extraction of Iberis amara seed oil. Journal of Applied Research on Medicinal and Aromatic Plants. 18: 100265 (2020a) https://doi.org/10.1016/j.jarmap.2020.100265

    Article  Google Scholar 

  • Liu X, Ou H, Gregersen H. Ultrasound-assisted supercritical CO2 extraction of cucurbitacin E from Iberis amara seeds. Industrial Crops and Products. 145: 112093 (2020b) https://doi.org/10.1016/j.indcrop.2020.112093

    Article  CAS  Google Scholar 

  • Lorenzo JM, Khaneghah AM, Gavahian M, Eş I, Munekata PES, Ferreira ICFR, Barba FJ, Lorenzo JM, Khaneghah AM, Gavahian M, Eş I, Munekata PES, Ferreira ICFR, Barba FJ. Understanding the potential benefits of thyme and its derived products for food industry and consumer health : From extraction of value-added compounds to the evaluation of and antimicrobial activities. Critical Reviews in Food Science and Nutrition. 59(18): 2879-2895 (2019) https://doi.org/10.1080/10408398.2018.1477730

    Article  CAS  PubMed  Google Scholar 

  • Low ZL, Low DYS, Tang SY, Manickam S, Tan KW, Ban ZH. Ultrasonic cavitation: An effective cleaner and greener intensification technology in the extraction and surface modification of nanocellulose. Ultrasonics Sonochemistry. 90: 106176 (2022)

    Article  PubMed  PubMed Central  Google Scholar 

  • Malakar S, Arora VK, Munshi M, Yadav DK, Pou KR, Deb S, Chandra R. Application of novel pretreatment technologies for intensification of drying performance and quality attributes of food commodities: a review. Food Science and Biotechnology. (2023) https://doi.org/10.1007/s10068-023-01322-0

  • Malakar S, Dhurve P, Arora VK. Modeling and optimization of osmo-sonicated dehydration of garlic slices in a novel infrared dryer using artificial neural network and response surface methodology. Journal of Food Process Engineering. (2022) https://doi.org/10.1111/jfpe.14261

  • Martínez JM, Delso C, Aguilar DE, Álvarez I, Raso J. Organic-solvent-free extraction of carotenoids from yeast Rhodotorula glutinis by application of ultrasound under pressure. Ultrasonics Sonochemistry. 61: 104833. (2020) https://doi.org/10.1016/j.ultsonch.2019.104833

    Article  CAS  PubMed  Google Scholar 

  • Mikheev IV, Pirogova MO, Usoltseva LO, Uzhel AS, Bolotnik TA, Kareev IE, Proskurnin MA. Green and rapid preparation of long-term stable aqueous dispersions of fullerenes and endohedral fullerenes: The pros and cons of an ultrasonic probe. Ultrasonics Sonochemistry. 73: 105533. (2021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mohammadpour H, Sadrameli SM, Eslami F, Asoodeh A. Optimization of ultrasound-assisted extraction of Moringa peregrina oil with response surface methodology and comparison with Soxhlet method. Industrial Crops and Products. 131: 106-116. (2019) https://doi.org/10.1016/j.indcrop.2019.01.030

    Article  CAS  Google Scholar 

  • Munekata PES, Alcántara C, Žugčić T, Abdelkebir R, Carmen M, García-pérez JV, Režek A, Gavahian M, Barba FJ, Lorenzo JM. Impact of ultrasound-assisted extraction and solvent composition on bioactive compounds and in vitro biological activities of thyme and rosemary. Food Research International. 134: 109242. (2020) https://doi.org/10.1016/j.foodres.2020.109242

    Article  CAS  PubMed  Google Scholar 

  • Nabet N, Gilbert-López B, Madani K, Herrero M, Ibáñez E, Mendiola JA. Optimization of microwave-assisted extraction recovery of bioactive compounds from Origanum glandulosum and Thymus fontanesii. Industrial Crops and Products. 129: 395-404. (2019)

    Article  CAS  Google Scholar 

  • Nguyen VT, Tran NTH, Tran TG. Central composite experimental design for ultrasound‐assisted extraction optimization of alkaloid compounds and antioxidant properties from cocoa pod husk (Theobroma cacao L.). Journal of Food Processing and Preservation. 46(11): e17084. (2022) https://doi.org/10.1111/jfpp.17084

    Article  CAS  Google Scholar 

  • Nieto, G. Ros, G. Castillo, J. Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review Gema. Medicines. 1-13. (2018) https://doi.org/10.3390/medicines5030098

    Article  PubMed  PubMed Central  Google Scholar 

  • Nishad J, Saha S, Kaur C. Enzyme- and ultrasound-assisted extractions of polyphenols from Citrus sinensis (cv. Malta) peel: A comparative study. Journal of Food Processing and Preservation. 43(8): 1-13. (2019) https://doi.org/10.1111/jfpp.14046

    Article  CAS  Google Scholar 

  • Palma A, Díaz MJ, Ruiz-Montoya M, Morales E, Giráldez I. Ultrasound extraction optimization for bioactive molecules from Eucalyptus globulus leaves through antioxidant activity. Ultrasonics Sonochemistry. 76: 105654. (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pandiselvam R, Aydar AY, Kutlu N, Aslam R, Sahni P, Mitharwal S, Kothakota A. Individual and interactive effect of ultrasound pre-treatment on drying kinetics and biochemical qualities of food: A critical review. Ultrasonics Sonochemistry. 92: 106261. (2022)

    Article  PubMed  PubMed Central  Google Scholar 

  • Proestos C. The benefits of plant extracts for human health. Foods. 9(11): 1653. (2020) https://doi.org/10.3390/foods9111653

    Article  PubMed  PubMed Central  Google Scholar 

  • Raheem M, Ahmed D, Aydar AY. The Optimization of Curcumin Extraction from Turmeric with Modern Techniques Using Response Surface Methodology. Latin American Applied Research. 53(2), 95-102. (2023)

    Article  CAS  Google Scholar 

  • Rahman MM, Byanju B, Grewell D, Lamsal BP. High-power sonication of soy proteins: Hydroxyl radicals and their effects on protein structure. Ultrasonics Sonochemistry. 64: 105019. (2020)

    Article  CAS  PubMed  Google Scholar 

  • Rao MV, Sengar AS, Sunil CK, Rawson A. Ultrasonication-A green technology extraction technique for spices: A review. Trends in Food Science & Technology. 116: 975-991. (2021)

    Article  CAS  Google Scholar 

  • Rao MV, Akhil KG, Sunil CK, Venkatachalapathy N, Jaganmohan R. Effect of microwave treatment on physical and functional properties of foxtail millet flour. International Journal of Chemical Studies. 9(1), 2762-2767. (2021)

    Article  Google Scholar 

  • Raza A, Li F, Xu X, Tang J. Optimization of Ultrasonic-assisted extraction of antioxidant polysaccharides from the stem of Trapa quadrispinosa using response surface methodology. International Journal of Biological Macromolecules. 94: 335-344. (2017) https://doi.org/10.1016/j.ijbiomac.2016.10.033

    Article  CAS  PubMed  Google Scholar 

  • Riaz U, Iqbal S, Sohail MI, Samreen T, Ashraf M, Akmal F, Siddiqui A, Ahmad I, Naveed M, Khan NI, Akhter RM. A Comprehensive Review on Emerging Importance and Economical Potential of Medicinal and Aromatic Plants (MAPs) in Current Scenario. Pakistan Journal of Agricultural Research. 34(2): 68-73. (2021) https://doi.org/10.17582/journal.pjar/2021/34.2.381.392

    Article  Google Scholar 

  • Riera E, Golás Y, Blanco A, Gallego JA, Blasco M, Mulet A. Mass transfer enhancement in supercritical fluids extraction by means of power ultrasound. Ultrasonics Sonochemistry. 11(3): 241-244. (2004) https://doi.org/10.1016/j.ultsonch.2004.01.019

    Article  CAS  PubMed  Google Scholar 

  • Riera EBA, García J, Benedito J, Mulet A, Gallego-Juárez JA, Blasco M. High-power ultrasonic system for the enhancement of mass transfer in supercritical CO2 extraction processes. Physics Procedia. 3(1): 141-146. (2010) https://doi.org/10.1016/j.phpro.2010.01.020

    Article  CAS  Google Scholar 

  • Rodrigues S, Fernandes FAN, Sousa E, Brito D, Dutra A, Narain N. Ultrasound extraction of phenolics and anthocyanins from jabuticaba peel. Industrial Crops & Products. 69: 400-407. (2015) https://doi.org/10.1016/j.indcrop.2015.02.059

    Article  CAS  Google Scholar 

  • Saifullah M, McCullum R, McCluskey A, Vuong Q. Comparison of conventional extraction technique with ultrasound assisted extraction on recovery of phenolic compounds from lemon scented tea tree (Leptospermum petersonii) leaves. Heliyon. 6(4): e03666. (2020) https://doi.org/10.1016/j.heliyon.2020.e03666

    Article  PubMed  PubMed Central  Google Scholar 

  • Santos MP, Souza MC, Sumere BR, da Silva LC, Cunha DT, Bezerra RMN, Rostagno MA. Extraction of bioactive compounds from pomegranate peel (Punica granatum L.) with pressurized liquids assisted by ultrasound combined with an expansion gas. Ultrasonics Sonochemistry. 54: 11-17. (2019) https://doi.org/10.1016/j.ultsonch.2019.02.021

    Article  CAS  PubMed  Google Scholar 

  • Santos L, Janet Z, Uribe AG, Benedito J. Effect of Solvent Composition on Ultrasound ‑ Generated Intensity and Its Influence on the Ultrasonically Assisted Extraction of Bioactives from Agave Bagasse ( Agave salmiana ). Food Engineering Reviews. 13: 713-725. (2021)https://doi.org/10.1007/s12393-020-09260-x

    Article  CAS  Google Scholar 

  • Senrayan, J. Venkatachalam, S. Optimization of ultrasound-assisted solvent extraction (UASE) based on oil yield, antioxidant activity and evaluation of fatty acid composition and thermal stability of Coriandrum sativum L. seed oil. Food Science and Biotechnology. 28(2): 377-386. (2019) https://doi.org/10.1007/s10068-018-0467-1

    Article  CAS  PubMed  Google Scholar 

  • Senrayan J, Venkatachalam S. Ultrasonic acoustic-cavitation as a novel and emerging energy efficient technique for oil extraction from kapok seeds. Innovative Food Science & Emerging Technologies. 62, 102347. (2020) https://doi.org/10.1016/j.ifset.2020.102347

    Article  CAS  Google Scholar 

  • Singla M, Sit N. Application of ultrasound in combination with other technologies in food processing: A review. Ultrasonics Sonochemistry. 73: 105506. (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sumere BR, de Souza MC, Dos Santos MP, Bezerra RMN, da Cunha DT, Martinez J, Rostagno MA. Combining pressurized liquids with ultrasound to improve the extraction of phenolic compounds from pomegranate peel (Punica granatum L.). Ultrasonics Sonochemistry. 48: 151-162. (2018) https://doi.org/10.1016/j.ultsonch.2018.05.028

    Article  CAS  PubMed  Google Scholar 

  • Sun Q, Du B, Wang C, Xu W, Fu Z, Yan Y, Zhang H. Ultrasound-Assisted Ionic Liquid Solid–Liquid Extraction Coupled with Aqueous Two-Phase Extraction of Naphthoquinone Pigments in Arnebia euchroma (Royle) Johnst. Chromatographia. 82: 1777-1789. (2019)

    Article  CAS  Google Scholar 

  • Susy J, Araújo FDe, Leite E, Souza D, Ribeiro J, Cristina A, Gomes A, Ryan L, Kotzebue V, Lincon D, Lomonaco D, Oliveira VDe, Elaine S, Leandro A, Tejo M. Microencapsulation of sweet orange essential oil ( Citrus aurantium var . dulcis ) by liophylization using maltodextrin and maltodextrin / gelatin mixtures : Preparation , characterization , antimicrobial. Journal of Biological Macromolecules. 14: 991-999. (2019)https://doi.org/10.1016/j.ijbiomac.2019.09.160

    Article  CAS  Google Scholar 

  • Taha, A. Mehany, T. Pandiselvam, R. Anusha Siddiqui, S. Mir, N A. Malik, M A. Hu, H. Sonoprocessing: Mechanisms and recent applications of power ultrasound in food. Critical Reviews in Food Science and Nutrition. 1-39. (2022) https://doi.org/10.1080/10408398.2022.2161464

    Article  PubMed  Google Scholar 

  • Tamidi AM, Lau KK, Khalit SH. A review of recent development in numerical simulation of ultrasonic-assisted gas-liquid mass transfer process. Computers & Chemical Engineering. 155: 107498. (2021)

    Article  CAS  Google Scholar 

  • Tang, W. Li, D. Lv, Y. Jiang, J. Extraction and removal of caffeine from green tea by ultrasonic‐enhanced supercritical fluid. Journal of Food Science, 75(4): C363–C368. (2010) https://doi.org/10.1111/j.1750-3841.2010.01604.x

    Article  CAS  PubMed  Google Scholar 

  • Tao Y, Wu P, Dai Y, Luo X, Manickam S, Li D. Show, P L. Bridge between mass transfer behavior and properties of bubbles under two-stage ultrasound-assisted physisorption of polyphenols using macroporous resin. Chemical Engineering Journal. 436: 135158. (2022) https://doi.org/10.1016/j.cej.2022.135158

    Article  CAS  Google Scholar 

  • Thilakarathna RCN, Siow LF, Tang TK, Chan ES, Lee YY. Physicochemical and antioxidative properties of ultrasound-assisted extraction of mahua (Madhuca longifolia) seed oil in comparison with conventional Soxhlet and mechanical extractions. Ultrasonics sonochemistry. 92: 106280. (2023)

    Article  CAS  PubMed  Google Scholar 

  • Torres-valenzuela LS, Ballesteros-gómez A. Green Solvents for the Extraction of High Added-Value Compounds from Agri-food Waste. Food Engineering Reviews. 12(1): 83-100. (2020)

    Article  CAS  Google Scholar 

  • Tsaltaki C, Katsouli M, Kekes T, Chanioti S, Tzia C. Comparison study for the recovery of bioactive compounds from Tribulus conventional extraction methods. Industrial Crops & Products. 142: 111875. (2019)https://doi.org/10.1016/j.indcrop.2019.111875

    Article  CAS  Google Scholar 

  • tul Kubra K, Ahmed D, Aydar AY, Qamar MT. Ultrasound-and heat-assisted extraction of glycyrrhizin from licorice by two glycerol-based DESs-Modeling and optimization as per response surface methodology. Sustainable Chemistry and Pharmacy. 31: 100910. (2023)

    Article  Google Scholar 

  • Vaeli N, Honarvar B, Esfandiari N, Aboosadi ZA. A laboratory study on extracting active ingredients from scrophularia striata boiss using ultrasound-assisted supercritical fluid extraction technique. South African Journal of Chemical Engineering. 35: 111-117. (2021)

    Article  Google Scholar 

  • Venkateswara Rao M, CK S, Rawson A, DV C. Modifying the plant proteins techno-functionalities by novel physical processing technologies: a review. Critical Reviews in Food Science and Nutrition. 1-22. (2021) https://doi.org/10.1080/10408398.2021.1997907

    Article  PubMed  Google Scholar 

  • Vernes L, Abert-Vian M, El Maâtaoui M, Tao Y, Bornard I, Chemat F. Application of ultrasound for green extraction of proteins from spirulina. Mechanism, optimization, modeling, and industrial prospects. Ultrasonics Sonochemistry. 54: 48-60. (2019)

    Article  CAS  PubMed  Google Scholar 

  • Vigano J, de Paula Assis BF, Nathia-Neves G, Dos Santos P, Meireles MAA, Veggi PC, Martinez J. Extraction of bioactive compounds from defatted passion fruit bagasse (Passiflora edulis sp.) applying pressurized liquids assisted by ultrasound. Ultrasonics Sonochemistry. 64: 104999. (2020)https://doi.org/10.1016/j.ultsonch.2020.104999

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Tong Y, Li W, Zhang X, Gao X, Yong J, Zhao J, Koike K. Enhanced ultrasound-assisted enzymatic hydrolysis extraction of quinolizidine alkaloids from Sophora alopecuroides L. seeds. Journal of Natural Medicines. 72(2): 424-432. (2018)https://doi.org/10.1007/s11418-017-1165-7

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Zhang X, Ma X, Zhang K, Li S, Wang X, Liu X, Liu J, Fan W, Li Y, Li Q, Zhu X. Study on the kinetic model, thermodynamic and physicochemical properties of Glycyrrhiza polysaccharide by ultrasonic assisted extraction. Ultrasonics Sonochemistry. 51: 249-257. (2019)https://doi.org/10.1016/j.ultsonch.2018.10.012

    Article  CAS  PubMed  Google Scholar 

  • Wang QY, Dong X, Yang J, Hu YH, Peng LQ, Zheng H, Cao J. Vesicle based ultrasonic-assisted extraction of saponins in Panax notoginseng. Food Chemistry. 303: 125394. (2020)https://doi.org/10.1016/j.foodchem.2019.125394

    Article  CAS  PubMed  Google Scholar 

  • Wang C, Li J, Cao Y, Huang J, Lin H, Zhao T, Li Q. Extraction and characterization of pectic polysaccharides from Choerospondias axillaris peels: Comparison of hot water and ultrasound-assisted extraction methods. Food Chemistry. 401: 134156. (2023)https://doi.org/10.1016/j.foodchem.2022.134156

    Article  CAS  PubMed  Google Scholar 

  • Wen C, Zhang J, Zhang H, Dzah CS, Zandile M, Duan Y, Luo X. Advances in ultrasound assisted extraction of bioactive compounds from cash crops–A review. Ultrasonics Sonochemistry. 48: 538-549. (2018)

    Article  CAS  PubMed  Google Scholar 

  • Wu J. Power Ultrasound for Extraction and Modification of Polysaccharides from Medicinal Fungi. In Advances in Food Processing Technology, Springer Singapore. (2019). https://doi.org/10.1007/978-981-13-6451-8

    Chapter  Google Scholar 

  • Yang Y-C, Wei M-C. Ethanol solution-modified supercritical carbon dioxide extraction of triterpenic acids from Hedyotis corymbosa with ultrasound assistance and determination of their solubilities. Separation and Purification Technology. 150: 204-214. (2015)https://doi.org/10.1016/j.seppur.2015.01.008

    Article  CAS  Google Scholar 

  • Yang YC, Wang CS, Wei MC. Development and validation of an ultrasound-assisted supercritical carbon-dioxide procedure for the production of essential oils from Perilla frutescens. LWT. 128: 109503. (2020)

    Article  CAS  Google Scholar 

  • Yang Y, Wang C, Wei M. Kinetics and mass transfer considerations for an ultrasound-assisted supercritical CO2 procedure to produce extracts enriched in fl avonoids from Scutellaria barbata. Journal of CO2 Utilization. 32: 219-231. (2019) https://doi.org/10.1016/j.jcou.2019.04.008

    Article  CAS  Google Scholar 

  • Yun C, Ji X, Chen Y, Zhao Z, Gao Y, Gu L, Wang H. Ultrasound-assisted enzymatic extraction of Scutellaria baicalensis root polysaccharide and its hypoglycemic and immunomodulatory activities. International Journal of Biological Macromolecules. 227: 134–145. (2023) https://doi.org/10.1016/j.ijbiomac.2022.12.115

    Article  CAS  PubMed  Google Scholar 

  • Yusoff IM, Taher ZM, Rahmat Z, Chua LS. A review of ultrasound-assisted extraction for plant bioactive compounds: Phenolics, flavonoids, thymols, saponins and proteins. Food Research International. 111268 (2022) https://doi.org/10.1016/j.foodres.2022.111268

    Article  PubMed  Google Scholar 

  • Zabot GL, Viganó J, Silva EK. Low-frequency ultrasound coupled with high-pressure technologies: Impact of hybridized techniques on the recovery of phytochemical compounds. Molecules. 26(17): 5117 (2021)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zahra W, Rai SN, Birla H, Singh SS, Rathore AS, Dilnashin H, Singh SP. Economic importance of medicinal plants in Asian countries. Bioeconomy for Sustainable Development. 359-377 (2020) https://doi.org/10.1007/978-981-13-9431-7_19

    Article  Google Scholar 

  • Zhang Z, Wang L, Li D, Jiao S, Dong X, Mao Z, Ultrasound-assisted extraction of oil from flaxseed. Separation and Purification Technology. 62: 192-198 (2008) https://doi.org/10.1016/j.seppur.2008.01.014

    Article  CAS  Google Scholar 

  • Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: a comprehensive review. Chinese Medicine (United Kingdom). 13(1): 1-26 (2018) https://doi.org/10.1186/s13020-018-0177-x

    Article  CAS  Google Scholar 

  • Zhao L-J, Xia B-H, Lin L-M, Xiong S-H, Tang J, Liao D-F. Optimization of ultrasound-assisted enzymatic polysaccharide extraction from turpiniae folium based on response surface methodology. Digital Chinese Medicine. 1(3): 239-246 (2018) https://doi.org/10.1016/s2589-3777(19)30031-x

    Article  Google Scholar 

Download references

Acknowledgements

All the authors are thankful to the National Institute of Food Technology Entrepreneurship and Management, Haryana, India, for providing support during the preparation of this review paper.

Author information

Authors and Affiliations

  1. Department of Food Engineering, National Institute of Food Technology Entrepreneurship and Management, Haryana, 131028, India

    Makdud Islam, Santanu Malakar & Nitin Kumar

  2. Department of Food Technology, Vignan’s Foundation for Science Technology and Research, Vadlamudi, Andhra Pradesh, India, 522213

    Madaraboina Venkateswara Rao

  3. Food Customization Research Lab, Centre for Rural Development and Technology, Indian Institute of Technology, Delhi, New Delhi, India

    Jatindra K. Sahu

Authors
  1. Makdud Islam
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Santanu Malakar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Madaraboina Venkateswara Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nitin Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jatindra K. Sahu
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MI: Conceptualization, Methodology, Writing—original draft. SM: Formal analysis, writing review & editing, MVR: Writing review & editing. NK: Conceptualization, supervision, writing review. JKS: Review and editing.

Corresponding authors

Correspondence to Nitin Kumar or Jatindra K. Sahu.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Islam, M., Malakar, S., Rao, M.V. et al. Recent advancement in ultrasound-assisted novel technologies for the extraction of bioactive compounds from herbal plants: a review. Food Sci Biotechnol 32, 1763–1782 (2023). https://doi.org/10.1007/s10068-023-01346-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-023-01346-6

Keywords

Search

Navigation