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Untargeted metabolite profiling of serum in rats exposed to pyrraline

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Abstract

Pyrraline, one of advanced glycation end-products, is formed in advanced Maillard reactions. It was reported that the presence of pyrraline was tested to be associated with nephropathy and diabetes. Pyrraline might result in potential health risks because many modern diets are heat processed. In the study, an integrated metabolomics by ultra-high-performance liquid chromatography with mass spectrometry was used to evaluate the effects of pyrraline on metabolism in rats. Thirty-two metabolites were identified as differential metabolites. Linolenic acid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, arachidonic acid metabolism, tyrosine metabolism and glycerophospholipid metabolism were the main perturbed networks in this pathological process. Differential metabolites and metabolic pathways we found give new insights into studying the toxic molecular mechanisms of pyrraline.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 31901808, 31972111, 31871772), Beijing Municipal Education Commission common project (KM201810011012), Beijing Excellent Talents Funding for Youth Scientist Innovation Team (201600026833TD01) and Project of High-level Teacher in Beijing Municipal Universities (IDHT20180506).

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Authors and Affiliations

  1. China-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Laboratory for Food Quality and Safety, Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry, Beijing Technology and Business University (BTBU), 11 Fucheng Road, Beijing, 100048, China

    Chuanqin Hu, Jiahui Wang, Fangyuan Qi, Yingli Liu, Fen Zhao, Jing Wang & Baoguo Sun

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  1. Chuanqin Hu
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  2. Jiahui Wang
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  3. Fangyuan Qi
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  4. Yingli Liu
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  5. Fen Zhao
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  6. Jing Wang
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  7. Baoguo Sun
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Contributions

CH: Investigation, Methodology, Writing-original draft, Conceptualization. JW: Methodology, Formal analysis, Visualization. FQ: Conceptualization. YL: Conceptualization. FZ: Conceptualization. JW: Conceptualization, Supervision, Funding acquisition. BS: Conceptualization. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jing Wang.

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The authors declare that they have no competing interests.

Ethical approval

The animal care and all experimental processes were conducted according to the European Community guidelines for using experimental animals. The study protocol was agreed by the Animal Care and Use Committee of Peking University Health Science Center. This article does not contain any studies with human participants performed by any of the author.

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Hu, C., Wang, J., Qi, F. et al. Untargeted metabolite profiling of serum in rats exposed to pyrraline. Food Sci Biotechnol 32, 1541–1549 (2023). https://doi.org/10.1007/s10068-023-01256-7

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  • DOI: https://doi.org/10.1007/s10068-023-01256-7

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