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Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice

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Abstract

In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.

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Acknowledgements

This work was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (115015-03-2-HD020).

Funding

Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET), Ministry of Agriculture, Food and Rural Affairs (MAFRA), Grant Number: 115015-03-2-HD020.

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Authors and Affiliations

  1. Hisol Inc., Namwon-si, Jeollabuk-do, Republic of Korea

    Hwa-Jin Kim

  2. Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA

    Mi-Kyoung You

  3. Department of Food and Nutrition, Mokpo National University, Muan-gun, Jeollanam-do, Republic of Korea

    Ziyun Wang, Young-Hyeon Lee & Hyeon-A Kim

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  1. Hwa-Jin Kim
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  2. Mi-Kyoung You
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Correspondence to Hyeon-A Kim.

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Kim, HJ., You, MK., Wang, Z. et al. Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice. Food Sci Biotechnol 29, 275–281 (2020). https://doi.org/10.1007/s10068-019-00710-9

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  • DOI: https://doi.org/10.1007/s10068-019-00710-9

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