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Analytical method validation for terbutryn using gas chromatography/ion trap, gas chromatography/mass selective detector, and liquid chromatography/triple quadrupole mass spectrometers

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Abstract

Analytical methods including solvent extraction followed by gas chromatography/ion-trap (GC/IT) with scan and MS/MS mode, a GC/mass selective detector (GC/MSD), and liquid chromatography/triple quadrupole mass spectrometers (LC/MS/MS) were optimized to identify and quantify terbutryn. The spike recovery was 96.5% using GC/IT with scan mode and 103.5% with MS/MS mode, 90.3% by GC/MSD, and 92.5% by LC/MS/MS. The limit of detection (LOD) was 0.0015 mg/kg by GC/IT with scan, 0.026 mg/kg with MS/MS mode, 0.015 mg/kg with GC/MSD, and 0.026 mg/kg by LC/MS/MS. Of the four methods, GC/IT with scan mode was determined to be the most sensitive (with LOD: 0.0015 mg/kg and limit of quantitation (LOQ): 0.0047 mg/kg), rapid (retention time: 9.6 min) and the most precise method (relative standard deviation: 17%) for the quantification of terbutryn. GC/IT with scan mode proved to be the more sensitive analytical method for terbutryn than other methods in this study, showing better accuracy and rapid analysis.

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Acknowledgements

This research was supported by High Value added Food Technology Development Program (Project Nos. 314078-3 and 316050-03) from Ministry of Agriculture, Food, and Rural Affairs (Republic of Korea).

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Authors and Affiliations

  1. Korea Food Research Institute, Anyangpangyo, Bundang, Seongnam, Gyeonggi, 13539, Korea

    Hae Won Jang, Jangho Lee, Hyunwook Choi & Tae Gyu Nam

  2. Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul, 05029, Korea

    Seung-Hyun Kim

  3. Food Biotechnology Program, Korea University of Science and Technology, Daejeon, 34113, Korea

    Jangho Lee

  4. Department of Food Science and Biotechnology, Dongguk University, 32, Dongguk-ro, Ilsandong-gu, Goyang, Gyeonggi-do, 10326, Korea

    Kwang-Geun Lee

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  1. Hae Won Jang
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Correspondence to Kwang-Geun Lee.

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Jang, H.W., Lee, J., Choi, H. et al. Analytical method validation for terbutryn using gas chromatography/ion trap, gas chromatography/mass selective detector, and liquid chromatography/triple quadrupole mass spectrometers. Food Sci Biotechnol 27, 1525–1530 (2018). https://doi.org/10.1007/s10068-018-0355-8

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  • DOI: https://doi.org/10.1007/s10068-018-0355-8

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