Skip to main content
Log in

Ethanolic extract from Rubus coreanus enhanced swimming capacity in mice

  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

Swimming enhancement effects of ethanol extract from ripe Rubus coreanus (RCE) fruits were investigated in mice. An Ex-RCE group was orally administered 1 g/kg body weight/day of RCE. An Ex-Control group received distilled water for 28 days. Exhaustive swimming times were significantly (p<0.05) prolonged in Ex-RCE mice, compared with Ex-Control mice. Ex-RCE mice had lower lactate and higher glucose levels after exhaustive swimming. Plasma non-esterified fatty acid levels in Ex-RCE mice were significantly (p<0.05) increased during swimming, compared with Ex-Control. Lower plasma triglyceride levels were shown in Ex-RCE mice after swimming. Ex-RCE mice exhibited higher muscle glycogen and lower malondialdehyde levels, compared with Ex-Control mice. RCE is a useful agent for enhancement of the swimming capacity and amelioration of physical fatigue via a decrease in lactate accumulation, and supply of energy sources via glycogen sparing and facilitation of fat use, and reduction of lipid peroxidation levels through swimming.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Deldicque L, Francaux M. Functional food for exercise performance: Fact or foe? Curr. Opin. Clin. Nutr. Metab. Care 11: 774–781 (2008)

    Article  CAS  Google Scholar 

  2. Mizunoya W, Haramizu S, Shibakusa T, Okabe Y, Fushiki T. Dietary conjugated linoleic acid increases endurance capacity and fat oxidation in mice during exercise. Lipids 40: 265–271 (2005)

    Article  CAS  Google Scholar 

  3. Murase T, Haramizu S, Shimotoyodome A, Tokimitsu I. Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288: 708–715 (2005)

    Article  Google Scholar 

  4. You Y, Kim K, Heo H, Lee K, Lee J, Shim S, Jun W. Stimulatory effects of Pseudosasa japonica leaves on exercise performance. Biosci. Biotech. Bioch. 70: 2532–2535 (2006)

    Article  CAS  Google Scholar 

  5. Lancha AH, Recco MB, Abdalla DSP, Curi R. Effect of aspartate, asparagines, and carnitine supplementation in the diet on metabolism of skeletal muscle during a moderate exercise. Physiol. Behav. 57: 367–371 (1995)

    Article  CAS  Google Scholar 

  6. Ishihara K, Yamada A, Mita Y, Goto A, Ishimi T, Mabuchi H, Inoue K, Fushiki T, Yasumoto K. Improved swimming pool achieves higher reproducibility and sensitivity to effect of food components as ergogenic AIDS. J. Nutr. Sci. Vitaminol. 55: 301–308 (2009)

    Article  CAS  Google Scholar 

  7. Aoi W, Naito Y, Yoshikawa T. Exercise and functional foods. Nutr. J. 5: 1–8 (2006)

    Article  Google Scholar 

  8. Fitts RH. Cellular mechanism of muscle fatigue. Physiol. Rev. 74: 49–94 (1994)

    CAS  Google Scholar 

  9. Coombes JS, Rowell B, Dodd JM, Demirel HA, Naito H, Shanely RA, Powers SK. Effects of vitamin E deficiency on fatigue and muscle contractile properties. Eur. J. Appl. Physiol. 87: 272–277 (2002)

    Article  CAS  Google Scholar 

  10. You L, Zhao M, Regenstin JM, Ren J. In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion. Food Chem. 124: 188–194 (2011)

    Article  CAS  Google Scholar 

  11. You Y, Park J, Yoon H, Lee Y, Hwang K, Lee J, Kim K, Lee K, Shim S, Jun W. Stimulatory effects of ferulic acid on endurance exercise capacity in mice. Biosci. Biotech. Bioch. 73: 1392–1397 (2009)

    Article  CAS  Google Scholar 

  12. Shim S, Chung J, Lee J, Hwang K, Sone J, Hong BS, Cho HY, Jun W. Hepatoprotective effects of black rice on superoxide anion radicals in HepG2 cells. Food Sci. Biotechnol. 15: 993–996 (2006)

    CAS  Google Scholar 

  13. Sawa T, Akaike T, Maeda H. Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase. J. Biol. Chem. 275: 32467–32474 (2000)

    Article  CAS  Google Scholar 

  14. Xu J, Li Y. Effects of salidroside on exhaustive exercise-induced oxidative stress in rats. Mol. Med. Rep. 6: 1195–1198 (2012)

    CAS  Google Scholar 

  15. Yu SH, Huang HY, Korivi M, Hsu MF, Huang CY, Hou CW, Chen CY, Kao CL, Lee RP, Lee SD, Kuo CH. Oral Rg1 supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles. J. Int. Soc. Sports Nutr. 9: 23 (2012)

    Article  CAS  Google Scholar 

  16. Lim JW, Hwnag HJ, Shin CS. Polyphenol compounds and anti-inflammatory activities of Korean black raspberry (Rubus coreanus Miquel) wines produced from juice supplemented with pulp and seed. J. Agr. Food Chem. 60: 5121–5127 (2012)

    Article  CAS  Google Scholar 

  17. Jeon SK, Lee JW, Lee IS. Effect of antioxidant activity and induction of DNA damage on human gastric cancer cell by Rubus coreanus Miquel. J. Life Sci. 17: 1723–1728 (2007)

    Article  Google Scholar 

  18. Lee S, You Y, Yoon HG, Kim K, Park J, Kim S, Ho JN, Lee J, Shim S, Jun W. Fatigue-alleviating effect on mice of an ethanolic extract from Rubus coreanus. Biosci. Biotech. Bioch. 75: 349–351 (2011)

    Article  CAS  Google Scholar 

  19. Matsumoto K, Ishihara K, Tanaka K, Inoue K, Fushiki T. An adjustable-current swimming pool for the evaluation of endurance capacity of mice. J. Appl. Physiol. 81: 1843–1849 (1996)

    CAS  Google Scholar 

  20. Gierus M, Rocha JB. Forage substitution in a grain-based diet affects pH and glycogen content of semimembranosus and semitendinosus rabbit muscles. J. Anim. Sci. 75: 2920–2924 (1997)

    CAS  Google Scholar 

  21. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Method. Enzymol. 186: 421–431 (1990)

    Article  CAS  Google Scholar 

  22. Bradford MA. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248–254 (1976)

    Article  CAS  Google Scholar 

  23. Moriura T, Matsuda H, Kubo M. Pharmacological study on Agkistrodon blomhoffii blomhoffii BOIE. V. anti-fatigue effect of the 50% ethanol extract in acute weight-loaded forced swimming-treated rats. Biol. Pharm. Bull. 19: 62–66 (1996)

    Article  CAS  Google Scholar 

  24. Jung KA, Kim IH, Han DS. Effect of medicinal plant extracts on forced swimming capacity in mice. J. Ethnopharmacol. 93: 75–81 (2004)

    Article  Google Scholar 

  25. Medbo JI. Glycogen breakdown and lactate accumulation during highintensity cycling. Acta Physiol. Scand. 149: 85–89 (1993)

    Article  CAS  Google Scholar 

  26. Jones NL, Havel RJ. Metabolism of free fatty acids and chylomicron triglycerides during exercise in rats. Am. J. Physiol. 213: 824–828 (1967)

    CAS  Google Scholar 

  27. Ikeuchi M, Yamaguchi K, Koyama T, Sono Y, Yazawa K. Effects of fenugreek seeds (Trigonella foenum greaecum) extract on endurance capacity in mice. J. Nutr. Sci. Vitaminol. 52: 287–292 (2006)

    Article  CAS  Google Scholar 

  28. Dohm GL, Tapscott EB, Barakat HA, Kasperek GJ. Influence of fasting on glycogen depletion in rats during exercise. J. Appl. Physiol. 55: 830–833 (1983)

    CAS  Google Scholar 

  29. Rennie MJ, Winder WW, Holloszy JO. A sparing effect of increased plasma fatty acids on muscle and liver glycogen content in the exercising rat. Biochem. J. 156: 647–655 (1976)

    Article  CAS  Google Scholar 

  30. Márquez R, Santángelo G, Sastre J, Goldschmidt P, Luyckx J, Pallardó FV, Viña J. Cyanoside chloride and chromocarbe diethylamine are more effective than vitamin C against exercise-induced oxidative stress. Pharmacol. Toxicol. 89: 255–258 (2001)

    Article  Google Scholar 

  31. Powers SK, Jackson MJ. Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production. Physiol. Rev. 88: 1243–1276 (2008)

    Article  CAS  Google Scholar 

  32. You Y, Kim K, Yoon HG, Lee KW, Lee J, Chun J, Shin DH, Park J, Jun W. Chronic effect of ferulic acid from Pseudosasa japonica leaves on enhancing exercise activity in mice. Phytother. Res. 24: 1508–1513 (2010)

    Article  CAS  Google Scholar 

  33. Lee S, You Y, Kim K, Park J, Jeong C, Jhon D, Jun W. Antioxidant activities of native Gwangyang Rubus coreanus Miq. J. Korean. Soc. Food Sci. Nutr. 41: 327–332 (2012)

    Article  CAS  Google Scholar 

  34. Swamy MS, Sivanna N, Tamatam A, Khanum F. Effect of poly phenols in enhancing the swimming capacity of rats. Funct. Foods Health Dis. 1: 482–491 (2011)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Woojin Jun.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

You, Y., Kim, K., Jeong, H. et al. Ethanolic extract from Rubus coreanus enhanced swimming capacity in mice. Food Sci Biotechnol 24, 2213–2217 (2015). https://doi.org/10.1007/s10068-015-0295-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-015-0295-5

Keywords

Navigation