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Diallyl trisulfide ameliorates arsenic induced dyslipidemia in rats

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Abstract

The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipidemia in the plasma and livers of rats was studied. Oral administration of As [5 mg/kg of body weight (BW)/day] for 4 weeks showed significant (p<0.05) increases in TC, LDL-C, VLDL-C, FFA, PL, and TG levels and the activity of HMG-CoA reductase in the plasma and liver, with significant (p<0.05) reductions in levels of HDL-C hepatic ubiquinones and activities of LCAT and LPL in the plasma and liver. Oral administration of DATS (80 mg/kg of BW) for 4 weeks in As intoxicated rats significantly (p<0.05) reduced plasma and liver TC, FFA, TGs, VLDL-C, and LDL-C levels, and the activity of HMG-CoA reductase, and significantly (p<0.05) increased the activities of LCAT and LPL and the levels of HDL-C and ubiquinone in the livers of rats. DATS protects against As-induced dyslipidemia in rats.

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Authors and Affiliations

  1. Department of Zoology, Annamalai University, Annamalainagar, 608002, Tamilnadu, India

    Selvaraj Miltonprabu & Naorem Chanu Sumedha

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  1. Selvaraj Miltonprabu
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  2. Naorem Chanu Sumedha
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Correspondence to Selvaraj Miltonprabu.

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Miltonprabu, S., Sumedha, N.C. Diallyl trisulfide ameliorates arsenic induced dyslipidemia in rats. Food Sci Biotechnol 24, 725–733 (2015). https://doi.org/10.1007/s10068-015-0094-z

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  • DOI: https://doi.org/10.1007/s10068-015-0094-z

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