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Anti-obesity effects of the stem bark of Japanese horse chestnut (Aesculus turbinate) in 3T3-L1 preadipocytes

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Abstract

The inhibitory effects of lipid accumulation on ethanol extract from stem bark of Japanese horse chestnut (JHC) were evaluated. Exposure to JHC extract (10–100 μg/mL) for a 72 h incubation period did not alter cell viability compared to the untreated control. JHC extract, with concentrations of 25, 50, and 100 μg/mL, inhibited lipid accumulation in 3T3-L1 adipocytes in a dose dependent manner. The expression of PPARγ and C/EBPα, important adpogenic key markers was significantly reduced when JHC extract was added to cells for 8 days compared with the untreated control group. These results suggest that JHC extract might be a potential therapeutic agent as a natural anti-obesity material.

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Authors and Affiliations

  1. Institute of Natural Medicine, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Hajin Nam & Jun Gyo Suh

  2. Gyeonggi Institute of Science and Technology Promotion, Suwon, Gyeonggi, 443-270, Korea

    Jin-Kyu Kim

  3. Department of Medical Genetics, College of Medicine, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Harry Jung & Jun Gyo Suh

Authors
  1. Hajin Nam
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  2. Jin-Kyu Kim
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  3. Harry Jung
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  4. Jun Gyo Suh
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Correspondence to Jun Gyo Suh.

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Nam, H., Kim, JK., Jung, H. et al. Anti-obesity effects of the stem bark of Japanese horse chestnut (Aesculus turbinate) in 3T3-L1 preadipocytes. Food Sci Biotechnol 23, 289–292 (2014). https://doi.org/10.1007/s10068-014-0040-5

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  • DOI: https://doi.org/10.1007/s10068-014-0040-5

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