Abstract
Gastrodia elata Blume (GE) has been used in traditional medicine as a sedative, an anti-convulsant and anti-epileptic drug. This study was performed to investigate antihyperglycemic effect of fermented-Gastrodia elata Blume (FGE) in streptozotocin (STZ)-induced type 1 diabetic mice. FGE was prepared by fermentation with Saccharomyces cerevisia. GE and FGE were orally administered at 20 or 100 mg/kg/day for 3 weeks to STZ (70 mg/kg)-induced diabetic mice. Administartion of FGE significantly reduced blood glucose levels in an oral glucose tolerance test (OGTT), fasting blood glucose (FBG), and glycosylated hemoglobin (HbA1c) compared to GE. In addition, FGE significantly decreased serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and at the same time markedly increased serum high density lipoprotein cholesterol (HDL-C) and plasma insulin levels. The results of this experimental study indicate that FGE possesses antihyperglycemic effect in STZ-induced diabetic mice.
Similar content being viewed by others
References
Callahan ST, Mansfield MJ. Type 2 diabetes mellitus in adolescents. Curr. Opin. Pediatr. 12: 310–315 (2000)
Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J. Ethnopharmacol. 104: 119–123 (2006)
Mahay S, Adeghate E, Lindley MZ, Rolph CE, Singh J. Streptozotocin-induced type 1 diabetes mellitus alters the morphology, secretory function and acyl lipid contents in the isolated rat parotid salivary gland. Mol. Cell. Biochem. 261: 175–181 (2004)
Williams G, Pickup JC. Handbook of Diabetes. 3rd ed. Blackwell Publishing Ltd., Oxford, UK. pp. 125–132 (1998)
Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetes potential. J. Ethnopharmacol. 81: 81–100 (2002)
Junod A, Lambert AE, Orci L, Pictet R, Gonet AE, Renold AE. Studies of the diabetogenic action of streptozotocin. Exp. Biol. Med. 126: 201–205 (1967)
Hakim ZS, Patel BK, Goyal RK. Effects of chronic ramipril treatment in streptozotocin-induced diabetic rats. Indian J. Physiol. Pharmacol. 41: 353–360 (1997)
Lu H, Kraut D, Gerstenfeld LC, Graves DT. Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology 144: 346–352 (2003)
Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet. Med. 22: 359–370 (2005)
Yang XD, Zhu J, Yang R, Liu JP, Li L, Zhang HB. Phenolic constituents from the rhizomes of Gastrodia elata. Nat. Prod. Res. 21: 180–186 (2007)
Hsieh CL, Chiang SY, Cheng KS, Lin YH, Tang NY, Lee CJ, Pon CZ, Hsieh CT. Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl. in kainic acid-treated rats. Am. J. Chinese Med. 29: 331–341 (2001)
Pei JC, Keng CL, Hui CL. Ching LH, Kuan PS, Mei CH, Lee YS. Gastrodia elata Bl. Attenuated learning deficits induced by forcedswimming stress in the inhibitory avoidance task and morris water maze. J. Med. Food 14: 610–617 (2011)
Hwang SM, Lee YJ, Kang DK, Lee HS. Anti-inflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells. Am. J. Chinese Med. 37: 395–406 (2009)
Park S, Kim DS, Kang S. Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: Vanillin and 4-hydroxybenzaldehyde are the bioactive candidates. Eur. J. Nutr. 50: 107–118 (2011)
Jung JW, Yoon BH, Oh HR, Ahn JH, Kim SY, Park SY, Ryu JH. Anxiolutic-like effects of Gastrodia elata and its phenolic constituents in mice. Biol. Pharm. Bull. 29: 261–265 (2006)
Xiang X, Yanying L, Xiaodong B. Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta. Med. 73: 650–654 (2007)
Yu SJ, Kim JR, Lee CK, Han JE, Lee JH, Kim HS, Hong JH, Kang SG. Gastrodia elata Blume and an active component, p-hydroxy benzylalcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Biol. Pharm. Bull. 28: 1016–1020 (2005)
Jang YW, Lee JY, Kim CJ. Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl. Int. Immunopharmacol. 10: 147–154 (2010)
Nevoigt E. Progress in metabolic engineering of Saccharomyces cerevisiae. Microbiol. Mol. Biol. R. 72: 379–412 (2008)
Jie Z, Jiguo H, Baoping J, Ye L, Xiaofeng Z. Antihyperglycemic activity of Prunella vulagricus L. in streptozotocin-induced diabetic mice. Asia. Pac. J. Clin. Nutr. 16: 427–431 (2007)
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499–502 (1972)
Jung YM, Lee SH, Lee DS, You MJ, Chung IK, Cheon WH, Kwon YS, Lee YJ, Ku SK. Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutr. Res. 31: 387–396 (2011)
Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH. Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity. Biol. Pharm. Bull. 25: 743–747 (2002)
Yang HJ, Weon JB, Lee B, Ma CJ. The alteration of components in the fermented Hwangryunhaedok-tang and its neuroprotective activity. Pharmacogn. Mag. 7: 207–212 (2011)
Kwon SU, Jeon SB, Xin M, Kim JH, Im JY, Cha JY, Jee HK, Lee OG, Kim DK, Lee YM. Inhibitory effect of fermented Gastrodia elata on high glucose-induced NO and IL-8 production in human umbilical vein endothelial cells. Nat. Prod. Sci. 18: 266–272 (2012)
Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem. 6: 24–27 (1969)
Yadav JP, Saini S, Kalia AN, Dangi AS. Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvodora oleoides in normal and alloxan-induced diabetic rats. Indian J. Pharmacol. 40(1): 23–27 (2008)
Kalaiarasi P, Pugalendi KV. Antihyperglycemic effect of 18 betaglycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocindiabetic rats. Eur. J. Pharmacol. 606: 269–273 (2009)
Ramesh B, Saravanan R, Pugalendi KV. Effect of dietary substitution of groundnut oil on blood glucose, lipid profile, and redoxstatus in streptozotocin-diabetic rats. Yale J. Biol. Med. 79: 9–17 (2006)
Chen J, Li WL, Wu JL, Ren BR, Zhang HQ. Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat [Eriobotrya japonica (Thunb.) Lindl.]. Phytomedicine 15: 98–102 (2008)
Xie JT, Wang A, Mehendale S, Wu J, Aung HH, Dey L, Qiu S, Yuan CS. Anti-diabetic effects of Gymnema yunnanense extract. Pharmacol. Res. 47: 323–329 (2003)
Attelem AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51: 1851–1858 (2002)
George D. New strategies for basal insulin treatment in type 2 diabetes mellitus. Clin. Ther. 26: 889–901 (2004)
Sim KC. Effect of each Gastrodia elata Blume concentration on antidiabeticin diabetic mellitus rats. Korean. J. Orient Physiol. Pathol. 21: 1477–1482 (2007)
Koenig RJ, Peterson CM, Jones RL, Saudek C, Lehrman M, Cerami A. Correlation of glucose regulation and hemoglobin A1 C in diabetes mellitus. New Engl. J. Med. 295: 417–420 (1976)
Nathan DM, Turjeon H, Regan S. Relationship between glycated hemoglobin levels and mean glucose level over time. Diabetologia 50: 2239–2244 (2007)
Ahmed I, Lakhani MS, Gillett M, John A, Raza H. Hypotriglyceridemic and hypocholesterolemic effects of antidiabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pr. 51: 155–161 (2001)
Mansi K, Amneh M, Nasr H. The hypolipidemic effects of Artemisia sieberi (A. herba-alba) in alloxan induced diabetic rats. Inter. J. Pharm. 3: 487–491 (2007)
Gong F, Li F, Zhang L, Li J, Zhang Z, Wang G. Hypoglycemic effects of crude polysaccharide from purslane. Int. J. Mol. Sci. 10: 880–888 (2009)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kwon, SU., Im, JY., Jeon, SB. et al. Antihyperglycemic effect of fermented Gastrodia elata blume in streptozotocin-induced diabetic mice. Food Sci Biotechnol 22, 1–6 (2013). https://doi.org/10.1007/s10068-013-0229-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10068-013-0229-z