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Anti-diabetic effect of the soybean extract fermented by Bacillus subtilis MORI in db/db mice

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Abstract

This study investigated the effects of soy bean extract fermented by Bacillus subtilis MORI (BTD-1) on blood glucose, hemoglobin A1c (HbA1c), plasma insulin, and pancreatic β islets in db/db mice. The BTD-1 (500 mg/kg) group showed significantly lower fasting blood glucose level (p<0.01) and postprandial 2 h blood glucose level (p<0.01) compared with the db control group. The BTD-1 (500 mg/kg) group showed significantly lower HbA1c level compared with the db control group (p<0.01). After 8 weeks of BTD-1 administration, the pancreatic islet architecture was preserved and the immunofluorescent intensities of insulin in BTD-1 (500mg/kg) group apparently increased compared to in the db control group. Plasma insulin levels were found to be significantly higher in the BTD-1 (500 mg/kg) group than in the db control group (p<0.05). In summary, our results suggest that BTD-1 has an anti-diabetes effect in a non-insulin dependent diabetes mellitus mouse model.

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Authors and Affiliations

  1. Institute of Natural Medicine, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Hajin Nam & Jun Gyo Suh

  2. Department of Medical Genetics, College of Medicine, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Harry Jung, S. Karuppasamy & Jun Gyo Suh

  3. R&D Center for Life Science, Biotopia Co., Ltd., Chuncheon, Gangwon, 200-883, Korea

    Young Shik Park, Yong Seok Cho, Jae Yeon Lee & Su-Il Seong

  4. Department of Life Science, University of Suwon, Hwaseong, Gyeonggi, 445-743, Korea

    Yong Seok Cho & Su-Il Seong

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  1. Hajin Nam
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  3. S. Karuppasamy
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Correspondence to Jun Gyo Suh.

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Nam, H., Jung, H., Karuppasamy, S. et al. Anti-diabetic effect of the soybean extract fermented by Bacillus subtilis MORI in db/db mice. Food Sci Biotechnol 21, 1669–1676 (2012). https://doi.org/10.1007/s10068-012-0222-y

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