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Antioxidant activity of cyanidins isolated from Ogapy (Acanthopanax divaricatus var. albeofructus) fruits in U937 macrophages

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Abstract

Reactive oxygen species (ROS) are continuously produced in aerobic organisms. Overproduction of ROS is known to play a crucial role in the pathogenesis of many cardiovascular diseases, including atherosclerosis and hypertension. Superoxide dismutase (SOD) and catalase (CAT) play critical roles on the removal of excess ROS. In the present study, we investigated the antioxidant activity of cyanidins from ogapy (Acanthopanax divaricatus var. albeofructus, ADA) fruits against oxidative stress in hydrogen peroxide (H2O2)-pretreated U937 macrophages, and explored the plausibility of the therapeutic effect of cyanidins on atherosclerosis. As a result, H2O2 generation and lipid peroxidation induced by H2O2-pretreatment was decreased by the treatment of cyanidins in U937 macrophages. In addition, increased activity of SOD and CAT was shown in H2O2-pretreated cells when treated with cyanidins. Overall, the results obtained in this study showed that cyanidin 3-galactoside and cyanidin 3-lathyroside from ADA fruits could protect macrophages against the damaging effects of H2O2 treatment.

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Authors and Affiliations

  1. Department of Chemistry, Seoul Women’s University, Seoul, 139-774, Korea

    Ai Hyang Shin & Won-Bong Park

  2. Department of Pharmacy, Sunchon National University, Suncheon, Jeonnam, 540-742, Korea

    Su-Yun Lyu

  3. Laboratory of Native Korean Acanthopanacis Remedies Production Co., Cheonan, Chungnam, 330-881, Korea

    Dug Ryong Hahn

Authors
  1. Su-Yun Lyu
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  2. Ai Hyang Shin
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  3. Dug Ryong Hahn
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  4. Won-Bong Park
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Correspondence to Won-Bong Park.

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Lyu, SY., Shin, A.H., Hahn, D.R. et al. Antioxidant activity of cyanidins isolated from Ogapy (Acanthopanax divaricatus var. albeofructus) fruits in U937 macrophages. Food Sci Biotechnol 21, 1445–1450 (2012). https://doi.org/10.1007/s10068-012-0190-2

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  • DOI: https://doi.org/10.1007/s10068-012-0190-2

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