Abstract
Biotin is an important vitamin functioning as coenzyme in several carboxylase-mediated metabolic reactions. Total 105 foods were selected as the target samples, of those 75 samples were highly and frequently consumed by Korean and the others were potently high biotin content foods. HPLC with the triple column system had been optimized and applied for the analysis of biotin in various food samples. The foods with the biotin concentration over 0.10 μg/g were 13 kinds of foods such as soybean (2.037 μg/g), soy milk (0.591 μg/g), pork liver (0.455 μg/g), etc. The total daily biotin exposure per person via average and the 95th percentile food intake was 44.656 and 169.416 μg, respectively. The Korean staple food, rice contributed as fifth diet for biotin intake (3.433 μg/person/day) following soybean (9.167 μg/person/day) > milk (6.018 μg/person/day) > soy milk (4.433 μg/person/day) > beer (4.428 μg/person/day).
Similar content being viewed by others
References
Livaniou E, Costopoulou D, Vassiliadou I, Leondiadis L, Nyala JO, Ithakissios DS, Evangelatos GP. Analytical techniques for determining biotin. J. Chromatogr. A 881: 331–343 (2000)
Mock DM, Shils ME, Olson JA, Shike M, Ross C. Modern Nutrition in Health and Disease. 9th ed. Lippincott, Williams and Wilkins, MD, USA. pp. 459–466 (1999)
Yomato C, Ohnishi Y. Determination of biotin following derivatization with 2-nitrophenylhydrazine by high-performance liquid chromatography with on-line UV detection and electrosprayionization mass spectrometry. J. Chromatogr. A 1142: 231–235 (2007)
Nojiri S, Kamata K, Nishijima M. Fluorescence detection of biotin using post-column derivatization with OPA in high performance liquid chromatography. J. Pharmaceut. Biomed. 16: 1357–1362 (1998)
Baldet P, Alban C, Douce R. Biotin synthesis in higher plants. Vol. 279, pp. 327–339. In: Vitamins and Coenzymes. Part I. In Methods in Enzymology. McCormick DB, Suttie JW, Wagner C (eds). Academic Press, San Diego, CA, USA (1997)
Höller U, Wachter F, Wehrli C, Fizet C. Quantification of biotin in feed, food, tablets, and premixes using HPLC-MSMS. J. Chromatogr. B 831: 8–16 (2006)
Bonjour JP. Biotin in human nutrition. Ann. NY Acad. Sci. 447: 97–104 (1985)
Bonjour JP, Machlin LJ. Handbook of Vitamins. Marcel Dekker, New York, NY, USA. p. 403 (1984)
Zemplini J, Mock DM. Human peripheral blood mononuclear cells: Inhibition of biotin transport by reversible competition with pantothenic acid is quantitatively minor. J. Nutr. Biochem. 10: 427–432 (1999)
FNB (Food and Nutrition Board) (2000) Dietary Reference Intakes: Vitamins, Available from: http://iom.edu/~/media/Files/Activity%20Files/Nutrition/DRIs/DRI_Vitamins.pdf. Accessed May 23, 2011.
Walter P. Towards ensuring the safety of vitamins and minerals. Toxicol. Lett. 120: 83–87 (2001)
Whitehead CC. Assessment of biotin deficiency in animals. Ann. NY Acad. Sci. 447: 86–96 (1985)
Watkins BA. Influences of biotin deficiency and dietary transfatty acids on tissue lipids in chickens. Brit. J. Nutr. 61: 99–111 (1988)
Said HM. Biotin bioavailability and estimated average requirement: Why bother? Am. J. Clin. Nutr. 69: 352–353 (1999)
Licanjou E, Costopoulou D, Vassiladou I, Leondiadis L, Nyalala JO, Ithalissios DS, Evangelatos GP. Analytical techniques for determining biotin. J. Chromatogr. A 881: 331–343 (2000)
Green NM. A spectrophotometric assay for avidin and biotin based on binding of dyes by avidin. J. Biochem. 94: 23C–24C (1965)
Shimada K, Nagase Y, Matumoto U. Studies on labeling and application to microanalysis of biotin related compounds. Yakugaku Zasshi 89: 403–409 (1969)
McCormick DB, Roth JA. Specificity, stereochemistry, and mechanism of the color reaction between p-dimethylaminocinnamaldehyde and biotin analogs. Anal. Biochem. 34: 226–236 (1970)
Nojiri S, Kamata K, Nishijima M. Fluorescence detection of biotin using post-column derivatization with OPA in high performance liquid chromatography. J. Pharmaceut. Biomed. 16: 1357–1362 (1998)
Kamata K, Hagrwara T, Takahashi, Uehara S, Nakayama K, Akiyama K. Determination of biotin in multivitamin pharmaceutical preparations by high-performance liquid chromatography with electrochemical detection. J. Chromatogr. 356: 326–330 (1986)
Azoulay M, Desbene PL, Frappier F. Use of liquid chromatography-mass spectrometry for the quantitation of dethiobiotin and biotin in biological samples. J. Chromatogr. 303: 272–276 (1984)
KFDA. Food Code. Section 10-115-10-118. Korea Food & Drug Administration, Seoul, Korea (2010)
Ekpe AE, Hazen C. Liquid chromatographic determination of biotin in multivitamine-multimineral tablets. J. Pharm. Biomed. Anal. 16: 1311–1315 (1998)
Lahely S, Ndaw S, Arella F, Hasselmann C. Determination of biotin in foods by high-performance liquid chromatography with post-column derivatives and fluorimetric detection. Food Chem. 65: 253–258 (1999)
Hardinge MG, Crools H. Lesser known vitamins in food. J. Am. Diet. Assoc. 38: 240–245 (1961)
Hayakawa K, Katsumata N, Hirano M, Yoshikawa K, Ogata T, Tanaka T, Nagamine T. Determination of biotin by the high performance affinity chromatography with a trypsin-treated avidin-bound column. J. Chromatogr. B 869: 93–100 (2008)
Expert Group on Vitamins and Minerals Revised review of biotin. EVM/01/02 Revisedaug. http://www.food.gov.uk/multimedia/pdfs/biotin.pdf. Accessed April 28, 2002.
IUNA. The North-South Ireland Food Consumption Survey. Food Safety Promotion Board, Dublin, Ireland (2001)
Staggs CG, Sealey WM, McCabe BJ, Teague AM, Mock DM. Determination of the biotin content of select foods using accurate and sensitive HPLC/avidin binding. J. Food Compos. Anal. 17: 767–776 (2004)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kim, JY., Oh, CH. Analysis of biotin in Korean representative foods and dietary intake assessment for Korean. Food Sci Biotechnol 20, 1043–1049 (2011). https://doi.org/10.1007/s10068-011-0142-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10068-011-0142-2