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Screening of Korean edible wild plants for estrogenic activity using MCF-7 cell proliferation assay

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Abstract

This present study was performed to investigate estrogenic activity of Korean edible wild plants for alternative of estrogen replacement therapy in postmenopausal women. When the estrogenic activity was measured by estrogen induced proliferation of MCF-7 cells, of investigated 29 extracts, 3 samples of kudzu vine (Pueraria thunbergiana), Cardamine leucantha, and David Vetchling (Lathyrus davidii) exhibited a significant proliferation of above 20% at concentration of 100 μg/mL. This stimulation of MCF-7 cell proliferation could be completely blocked by addition of estrogen antagonist ICI 182,780 (100 nM), indicating estrogen receptor-dependent mechanism of these estrogenic effects on MCF-7 cell proliferation.

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Authors and Affiliations

  1. Functional Food & Nutrition Division, Department of Agro-Food Resources, National Academy of Agricultural Science, Rural Development Administration, Suwon, Gyeonggi, 441-853, Korea

    Young Min Lee, Ji Hyun Bae, Jin Young Lee, Hwan Hee Jang, Dong Sik Park & Jae-Hyun Kim

  2. Ellead Skin Research Center, Seongnam, Gyeonggi, 463-824, Korea

    Ho Young Jung

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  1. Young Min Lee
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  2. Ho Young Jung
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  4. Jin Young Lee
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  5. Hwan Hee Jang
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  7. Jae-Hyun Kim
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Correspondence to Jae-Hyun Kim.

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Lee, Y.M., Jung, H.Y., Bae, J.H. et al. Screening of Korean edible wild plants for estrogenic activity using MCF-7 cell proliferation assay. Food Sci Biotechnol 20, 829–833 (2011). https://doi.org/10.1007/s10068-011-0115-5

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  • DOI: https://doi.org/10.1007/s10068-011-0115-5

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