Skip to main content

Advertisement

SpringerLink
Log in

Autonomic dysfunction and cardiovascular risk in psoriatic arthritis

  • Review Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Psoriatic arthritis (PsA) is an inflammatory disease with a high prevalence of cardiovascular (CV) events due to traditional cardiovascular risk factors and increased systemic inflammation. In this review, our objectives were to (i) evaluate the cardiovascular events and risk factors and (ii) investigate the relationship between autonomic dysfunction and CV diseases in PsA. A systematic review of the literature was done on the Medline/PubMed, Scopus, and the Directory of Open Access Journals databases between January 2017 and July 2022. After screening and exclusions, 73 studies were included for the final review. Patients with PsA have a greater risk of CV diseases and increased traditional CV risk factors, including hypertension, diabetes mellitus, obesity, metabolic syndrome, and dyslipidemia. Although autonomic dysfunction is more common in PsA than in the general population, its relationship with increased CV diseases in these patients is still unclear. Limitations in explaining CV risk in these patient groups complicate patient assessment as cardiovascular risk factors are linked to the morbidity and mortality of PsA, and it is essential to improve an optimal screening and management strategy for CV disease. All CV risk scoring systems cannot fully assess the CV risk in these patients, so in addition to scoring systems, carotid ultrasound evaluation may be a part of the CV evaluation.

Key Points

• Psoriatic arthritis is associated with an increased risk of cardiovascular disease due to traditional cardiovascular risk factors, increased systemic inflammation, and autonomic system dysfunction, although not fully demonstrated.

• The autonomic nervous system is crucial in regulating cardiovascular disease through its effect on the heart, blood vessels, and kidneys. Although the relationship between autonomic dysfunction and cardiovascular diseases has been shown, this relationship is still unclear in PsA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ritchlin CT, Colbert RA, Gladman DD (2017) Psoriatic arthritis. N Engl J Med 376:957–970. https://doi.org/10.1056/nejmra1505557

    Article  PubMed  Google Scholar 

  2. López-Medina C, Chevret S, Molto A, Sieper J, Duruöz T, Kiltz U, Elzorkany B, Hajjaj-Hassouni N, Burgos-Vargas R, Maldonado-Cocco J, Ziade N, Gavali M, Navarro-Compan V, Luo SF, Biglia A, Tae-Jong K, Kishimoto M, Pimentel-Santos FM, Gu J, Muntean L, van Gaalen FA, Geher P, Magrey M, Ibáñez-Vodnizza SE, Bautista-Molano W, Maksymowych W, Machado PM, Landewé R, van der Heijde D, Dougados M (2021) Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study. RMD Open 7:e001728. https://doi.org/10.1136/rmdopen-2021-001728

  3. Husted JA, Thavaneswaran A, Chandran V, Gladman DD (2013) Incremental effects of comorbidity on quality of life in patients with psoriatic arthritis. J Rheumatol 40:1349–1356. https://doi.org/10.3899/jrheum.121500

    Article  PubMed  Google Scholar 

  4. Polachek A, Touma Z, Anderson M, Eder L (2017) Risk of cardiovascular morbidity in patients with psoriatic arthritis: a meta-analysis of observational studies. Arthritis Care Res (Hoboken) 69:67–74. https://doi.org/10.1002/acr.22926

    Article  PubMed  Google Scholar 

  5. Lauper K, Courvoisier DS, Chevallier P, Finckh A, Gabay C (2018) Incidence and prevalence of major adverse cardiovascular events in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis. Arthritis Care Res (Hoboken) 70:1756–1763. https://doi.org/10.1002/acr.23567

    Article  PubMed  Google Scholar 

  6. Provan SA, Olstad DS, Solberg EE, Smedslund G, Dagfinrud H (2018) Evidence of reduced parasympathetic autonomic regulation in inflammatory joint disease: a meta-analyses study. Semin Arthritis Rheum 48:134–140. https://doi.org/10.1016/j.semarthrit.2017.11.010

    Article  PubMed  Google Scholar 

  7. Haque N, Lories RJ, de Vlam K (2016) Comorbidities associated with psoriatic arthritis compared with non-psoriatic spondyloarthritis: a cross-sectional study. J Rheumatol 43:376–382. https://doi.org/10.3899/jrheum.141359

    Article  CAS  PubMed  Google Scholar 

  8. Yagensky V, Schirmer M (2022) Cardiovascular risks and risk stratification in inflammatory joint diseases: a cross-sectional study. Front Med (Lausanne) 9:786776. https://doi.org/10.3389/fmed.2022.786776

    Article  PubMed  Google Scholar 

  9. Sinnathurai P, Buchbinder R, Hill C, Lassere M, March L (2018) Comorbidity in psoriatic arthritis and rheumatoid arthritis. Intern Med J 48:1360–1368. https://doi.org/10.1111/imj.14046

    Article  CAS  PubMed  Google Scholar 

  10. Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD (2011) Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int 31:1409–1417. https://doi.org/10.1007/s00296-011-1999-3

    Article  PubMed  Google Scholar 

  11. Lorenzo A, Pardo E, Charca L, Pino M, Queiro R (2020) Enthesitis and joint erosions are disease traits associated with cardiovascular risk in psoriatic arthritis. Clin Rheumatol 39:2973–2979. https://doi.org/10.1007/s10067-020-05088-2

    Article  PubMed  Google Scholar 

  12. Charlton R, Green A, Shaddick G, Snowball J, Nightingale A, Tillett W, Smith C, McHugh N (2019) Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: a population-based cohort study. Rheumatology (Oxford) 58:144–148. https://doi.org/10.1093/rheumatology/key286

    Article  PubMed  Google Scholar 

  13. Navarini L, Margiotta DPE, Caso F, Currado D, Tasso M, Angeletti S, Ciccozzi M, Scarpa R, Afeltra A, Costa L (2018) Performances of five risk algorithms in predicting cardiovascular events in patients with psoriatic arthritis: an Italian bicentric study. PLoS ONE 13:e0205506. https://doi.org/10.1371/journal.pone.0205506

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Bengtsson K, Forsblad-d’Elia H, Lie E, Klingberg E, Dehlin M, Exarchou S, Lindström U, Askling J, Jacobsson LTH (2017) Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study. Arthritis Res Ther 19:102. https://doi.org/10.1186/s13075-017-1315-z

    Article  PubMed  PubMed Central  Google Scholar 

  15. Degboé Y, Koch R, Zabraniecki L, Jamard B, Couture G, Ruidavets JB, Ferrieres J, Ruyssen-Witrand A, Constantin A (2022) Increased cardiovascular risk in psoriatic arthritis: results from a case-control monocentric study. Front Med (Lausanne) 9:785719. https://doi.org/10.3389/fmed.2022.785719

    Article  PubMed  Google Scholar 

  16. Egeberg A, Thyssen JP, Jensen P, Gislason GH, Skov L (2017) Risk of myocardial infarction in patients with psoriasis and psoriatic arthritis: a nationwide cohort study. Acta Derm Venereol 97:819–824. https://doi.org/10.2340/00015555-2657

    Article  CAS  PubMed  Google Scholar 

  17. Egeberg A, Skov L, Hansen PR, Gislason GH, Wu JJ, Thyssen JP, Mallbris L (2018) Duration of psoriatic arthritis as a risk factor for myocardial infarction. Rheumatol Adv Pract 2:rky011. https://doi.org/10.1093/rap/rky011

  18. Jatwani S, Jatwani K, Tiwari P, Wadhwa N, Chugh K (2021) Trends in hospitalisations and inpatient mortality from acute myocardial infarction among patients with psoriatic arthritis: an analysis of nationwide inpatient sample 2004–2014. Clin Exp Rheumatol 39:790–794. https://doi.org/10.55563/clinexprheumatol/kh5h6s

  19. Ogdie A, Maliha S, Shin D, Love TJ, Baker J, Jiang Y, Choi H, Gelfand JM (2017) Cause-specific mortality in patients with psoriatic arthritis and rheumatoid arthritis. Rheumatology (Oxford) 56:907–911. https://doi.org/10.1093/rheumatology/kew502

    Article  PubMed  Google Scholar 

  20. Colaco K, Widdifield J, Luo J, Rosen CF, Alhusayen R, Paterson JM, Campbell W, Tu K, Bernatsky S, Gladman DD, Eder L (2021) Trends in mortality and cause-specific mortality among patients with psoriasis and psoriatic arthritis in Ontario, Canada. J Am Acad Dermatol 84:1302–1309. https://doi.org/10.1016/j.jaad.2020.10.031

    Article  PubMed  Google Scholar 

  21. Schieir O, Tosevski C, Glazier RH, Hogg-Johnson S, Badley EM (2017) Incident myocardial infarction associated with major types of arthritis in the general population: a systematic review and meta-analysis. Ann Rheum Dis 76:1396–1404. https://doi.org/10.1136/annrheumdis-2016-210275

    Article  PubMed  Google Scholar 

  22. Tinggaard AB, Hjuler KF, Andersen IT, Winther S, Iversen L, Bøttcher M (2021) Prevalence and severity of coronary artery disease linked to prognosis in psoriasis and psoriatic arthritis patients: a multi-centre cohort study. J Intern Med 290:693–703. https://doi.org/10.1111/joim.13311

    Article  CAS  PubMed  Google Scholar 

  23. Ogdie A, Kay McGill N, Shin DB, Takeshita J, Jon Love T, Noe MH, Chiesa Fuxench ZC, Choi HK, Mehta NN, Gelfand JM (2018) Risk of venous thromboembolism in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a general population-based cohort study. Eur Heart J 39:3608–3614. https://doi.org/10.1093/eurheartj/ehx145

    Article  PubMed  Google Scholar 

  24. Galloway J, Barrett K, Irving P, Khavandi K, Nijher M, Nicholson R, de Lusignan S, Buch MH (2020) Risk of venous thromboembolism in immune-mediated inflammatory diseases: a UK matched cohort study. RMD Open 6(3):e001392. https://doi.org/10.1136/rmdopen-2020-001392

  25. Gazitt T, Pesachov J, Lavi I, Elias M, Haddad A, Feldhamer I, Cohen AD, Saliba W, Zisman D (2022) The association between psoriatic arthritis and venous thromboembolism: a population-based cohort study. Arthritis Res Ther 24:16. https://doi.org/10.1186/s13075-021-02703-8

    Article  PubMed  PubMed Central  Google Scholar 

  26. Eder L, Harvey P, Chandran V, Rosen CF, Dutz J, Elder JT, Rahman P, Ritchlin CT, Rohekar S, Hayday R, Barac S, Feld J, Zisman D, Gladman DD (2018) Gaps in diagnosis and treatment of cardiovascular risk factors in patients with psoriatic disease: an international multicenter study. J Rheumatol 45:378–384. https://doi.org/10.3899/jrheum.170379

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Jafri K, Bartels CM, Shin D, Gelfand JM, Ogdie A (2017) Incidence and management of cardiovascular risk factors in psoriatic arthritis and rheumatoid arthritis: a population-based study. Arthritis Care Res (Hoboken) 69:51–57. https://doi.org/10.1002/acr.23094

    Article  PubMed  Google Scholar 

  28. Landgren AJ, Dehlin M, Jacobsson L, Bergsten U, Klingberg E (2021) Cardiovascular risk factors in gout, psoriatic arthritis, rheumatoid arthritis and ankylosing spondylitis: a cross-sectional survey of patients in Western Sweden. RMD Open 7(2):e001568. https://doi.org/10.1136/rmdopen-2021-001568

  29. Queiro R, Lorenzo A, Tejón P, Pardo E, Coto P, Ballina J (2019) Polyarticular evolution and late-onset psoriasis may be associated with cardiovascular disease in psoriatic arthritis. Int J Rheum Dis 22:269–274. https://doi.org/10.1111/1756-185x.13421

    Article  PubMed  Google Scholar 

  30. Kavadichanda C, Shanoj KC, Ganapathy S, Shah SI, Ananthakrishnan R, Sahoo J, Negi VS (2022) Factors associated with high cardiovascular risk in psoriatic arthritis and non-psoriatic spondyloarthritis. Rheumatol Int 42:251–260. https://doi.org/10.1007/s00296-021-05064-2

    Article  CAS  PubMed  Google Scholar 

  31. Lam SHM, Cheng IT, Li EK, Wong P, Lee J, Yip RM, Yim CW, Ying SK, Li M, Li TK, Lee AP, Tam LS (2020) DAPSA, carotid plaque and cardiovascular events in psoriatic arthritis: a longitudinal study. Ann Rheum Dis 79:1320–1326. https://doi.org/10.1136/annrheumdis-2020-217595

    Article  CAS  PubMed  Google Scholar 

  32. Cheng IT, Li EK, Wong PC, Law MY, Yim IC, Lai BT, Ying SK, Kwok KY, Li M, Li TK, Lee JJ, Szeto CC, Yan BP, Lee AP, Tam LS (2020) Treat to target and prevention of subclinical atherosclerosis in psoriatic arthritis-which target should we choose? Rheumatology (Oxford) 59:2881–2892. https://doi.org/10.1093/rheumatology/keaa025

    Article  CAS  PubMed  Google Scholar 

  33. Apraş Bilgen Ş, Kalyoncu U, Erden A, Canpolat U, Kılıç L, Karadağ Ö, Aytemir K, Kiraz S, Akdoğan A, Ertenli İ (2018) Assessment of subclinical atherosclerosis in psoriatic arthritis patients without clinically overt cardiovascular disease or traditional atherosclerosis risk factors. Turk Kardiyol Dern Ars 46:358–365. https://doi.org/10.5543/tkda.2018.36169

    Article  PubMed  Google Scholar 

  34. Arias de la Rosa I, Font P, Escudero-Contreras A, López-Montilla MD, Pérez-Sánchez C, Ábalos-Aguilera MC, Ladehesa-Pineda L, Ibáñez-Costa A, Torres-Granados C, Jimenez-Gomez Y, Patiño-Trives A, Luque-Tévar M, Castro-Villegas MC, Calvo-Gutiérrez J, Ortega-Castro R, López-Pedrera C, Collantes-Estévez E, Barbarroja N (2020) Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis. Ther Adv Chronic Dis 11:2040622320965067. https://doi.org/10.1177/2040622320965067

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Xiong L, Tian G, Leung H, Soo YOY, Chen X, Ip VHL, Mok VCT, Chu WCW, Wong KS, Leung TWH (2018) Autonomic dysfunction predicts clinical outcomes after acute ischemic stroke: a prospective observational study. Stroke 49:215–218. https://doi.org/10.1161/strokeaha.117.019312

    Article  PubMed  Google Scholar 

  36. Gaydukova I, Rebrov A, Nikitina N, Poddubnyy D (2012) Decreased heart rate variability in patients with psoriatic arthritis. Clin Rheumatol 31:1377–1381. https://doi.org/10.1007/s10067-012-2015-3

    Article  PubMed  Google Scholar 

  37. Adlan AM, Lip GY, Paton JF, Kitas GD, Fisher JP (2014) Autonomic function and rheumatoid arthritis: a systematic review. Semin Arthritis Rheum 44(3):283–304. https://doi.org/10.1016/j.semarthrit.2014.06.003

    Article  PubMed  Google Scholar 

  38. Rupprecht S, Finn S, Hoyer D, Guenther A, Witte OW, Schultze T, Schwab M (2020) Association between systemic inflammation, carotid arteriosclerosis, and autonomic dysfunction. Transl Stroke Res 11:50–59. https://doi.org/10.1007/s12975-019-00706-x

    Article  CAS  PubMed  Google Scholar 

  39. Gezer HH, Erdem Gürsoy D, Acer Kasman S, Duruöz MT (2022) Assessment of autonomic dysfunction with the COMPASS-31 and its relationship with disease activity and cardiovascular risks in patients with psoriatic arthritis. Rheumatol Int 42:1539–1548. https://doi.org/10.1007/s00296-022-05110-7

    Article  CAS  PubMed  Google Scholar 

  40. Brock C, Rasmussen SE, Drewes AM, Møller HJ, Brock B, Deleuran B, Farmer AD, Pfeiffer-Jensen M (2021) Vagal nerve stimulation-modulation of the anti-inflammatory response and clinical outcome in psoriatic arthritis or ankylosing spondylitis. Mediators Inflamm 2021:9933532. https://doi.org/10.1155/2021/9933532

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Wibetoe G, Ikdahl E, Rollefstad S, Olsen IC, Bergsmark K, Kvien TK, Salberg A, Soldal DM, Bakland G, Lexberg Å, Fevang BT, Gulseth HC, Haugeberg G, Semb AG (2017) Cardiovascular disease risk profiles in inflammatory joint disease entities. Arthritis Res Ther 19:153. https://doi.org/10.1186/s13075-017-1358-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Gulati AM, Salvesen Ø, Thomsen RS, Kavanaugh A, Semb AG, Rollefstad S, Haugeberg G, Hoff M (2018) Change in cardiovascular risk factors in patients who develop psoriatic arthritis: longitudinal data from the Nord-Trøndelag Health Study (HUNT). RMD Open 4:e000630. https://doi.org/10.1136/rmdopen-2017-000630

    Article  PubMed  PubMed Central  Google Scholar 

  43. Kibari A, Cohen AD, Gazitt T, Bitterman H, Lavi I, Feldhamer I, Shalom G, Greenberg-Dotan S, Zisman D (2019) Cardiac and cardiovascular morbidities in patients with psoriatic arthritis: a population-based case control study. Clin Rheumatol 38:2069–2075. https://doi.org/10.1007/s10067-019-04528-y

    Article  PubMed  Google Scholar 

  44. Kaine J, Song X, Kim G, Hur P, Palmer JB (2019) Higher incidence rates of comorbidities in patients with psoriatic arthritis compared with the general population using U.S. administrative claims data. J Manag Care Spec Pharm 25:122–132.https://doi.org/10.18553/jmcp.2018.17421

  45. Cooksey R, Brophy S, Kennedy J, Gutierrez FF, Pickles T, Davies R, Piguet V, Choy E (2018) Cardiovascular risk factors predicting cardiac events are different in patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis. Semin Arthritis Rheum 48:367–373. https://doi.org/10.1016/j.semarthrit.2018.03.005

    Article  PubMed  Google Scholar 

  46. Nissen CB, Hørslev-Petersen K, Primdahl J (2017) Cardiovascular risk profiles in a hospital-based population of patients with psoriatic arthritis and ankylosing spondylitis: a cross-sectional study. Rheumatol Int 37:113–120. https://doi.org/10.1007/s00296-016-3614-0

    Article  PubMed  Google Scholar 

  47. Özkul Ö, Yazıcı A, Aktürk AS, Karadağ DT, Işık ÖO, Tekeoğlu S, Cefle A (2019) Are there any differences among psoriasis, psoriatic arthritis and rheumatoid arthritis in terms of metabolic syndrome and cardiovascular risk factors? Eur J Rheumatol 6:174–178. https://doi.org/10.5152/eurjrheum.2019.19029

    Article  PubMed  Google Scholar 

  48. Queiro R, Lorenzo A, Tejón P, Coto P, Pardo E (2019) Obesity in psoriatic arthritis: comparative prevalence and associated factors. Medicine (Baltimore) 98:e16400. https://doi.org/10.1097/md.0000000000016400

    Article  PubMed  Google Scholar 

  49. Wang Q, Luo Y, Chen M, Zheng X, Zhu W, Shen M, Kuang Y (2021) Comparison of behavioral risk factors and cardiometabolic comorbidities of psoriatic arthritis and psoriasis: a case-control study in chinese patients. Ther Clin Risk Manag 17:397–404. https://doi.org/10.2147/tcrm.s307102

    Article  PubMed  PubMed Central  Google Scholar 

  50. Anyfanti P, Gkaliagkousi E, Triantafyllou A, Koletsos N, Gavriilaki E, Galanopoulou V, Aslanidis S, Douma S (2021) Hypertension in rheumatic diseases: prevalence, awareness, treatment, and control rates according to current hypertension guidelines. J Hum Hypertens 35:419–427. https://doi.org/10.1038/s41371-020-0348-y

    Article  PubMed  Google Scholar 

  51. Queiro R, Lorenzo A, Tejón P, Pardo E, Coto P (2019) Hypertension is associated with increased age at the onset of psoriasis and a higher body mass index in psoriatic disease. Clin Rheumatol 38:2063–2068. https://doi.org/10.1007/s10067-019-04519-z

    Article  PubMed  Google Scholar 

  52. Toussirot E, Aubin F, Desmarets M, Wendling D, Augé B, Gillard J, Messica O, Guillot X, Laheurte C, Monnet E, Dumoulin G (2021) Visceral adiposity in patients with psoriatic arthritis and psoriasis alone and its relationship with metabolic and cardiovascular risk. Rheumatology (Oxford) 60:2816–2825. https://doi.org/10.1093/rheumatology/keaa720

    Article  CAS  PubMed  Google Scholar 

  53. Landgren AJ, Bilberg A, Eliasson B, Larsson I, Dehlin M, Jacobsson L, Klingberg E (2020) Cardiovascular risk factors are highly overrepresented in Swedish patients with psoriatic arthritis compared with the general population. Scand J Rheumatol 49:195–199. https://doi.org/10.1080/03009742.2019.1672783

    Article  CAS  PubMed  Google Scholar 

  54. Erdem Gürsoy D, Gezer HH, Acer Kasman S, Duruöz MT (2022) Validity and psychometric characteristics of the self-administered comorbidity questionnaire in patients with psoriatic arthritis. Rheumatol Int 42(11):2061–2067. https://doi.org/10.1007/s00296-022-05150-z

    Article  PubMed  Google Scholar 

  55. Gupta S, Syrimi Z, Hughes DM, Zhao SS (2021) Comorbidities in psoriatic arthritis: a systematic review and meta-analysis. Rheumatol Int 41:275–284. https://doi.org/10.1007/s00296-020-04775-2

    Article  PubMed  PubMed Central  Google Scholar 

  56. Schwartz DM, Parel P, Li H, Sorokin AV, Berg AR, Chen M, Dey A, Hong CG, Playford M, Sylvester M, Teague H, Siegel E, Mehta NN (2022) PET/CT-based characterization of 18F-FDG uptake in various tissues reveals novel potential contributions to coronary artery disease in psoriatic arthritis. Front Immunol 13:909760. https://doi.org/10.3389/fimmu.2022.909760

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Xie W, Huang H, Deng X, Gao D, Zhang Z (2021) Modifiable lifestyle and environmental factors associated with onset of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational studies. J Am Acad Dermatol 84:701–711. https://doi.org/10.1016/j.jaad.2020.08.060

    Article  PubMed  Google Scholar 

  58. Fernández-Carballido C, Martín-Martínez MA, García-Gómez C, Castañeda S, González-Juanatey C, Sánchez-Alonso F, García de Vicuña R, Erausquin-Arruabarrena C, López-Longo J, Sánchez MD, Corrales A, Quesada-Masachs E, Chamizo E, Barbadillo C, Bachiller-Corral J, Cobo-Ibañez T, Turrión A, Giner E, Llorca J, González-Gay MA (2020) Impact of comorbidity on physical function in patients with ankylosing spondylitis and psoriatic arthritis attending rheumatology clinics: results from a cross-sectional Study. Arthritis Care Res (Hoboken) 72:822–828. https://doi.org/10.1002/acr.23910

    Article  CAS  PubMed  Google Scholar 

  59. Gok K, Nas K, Tekeoglu I, Sunar I, Keskin Y, Kilic E, Sargin B, Acer Kasman S, Alkan H, Sahin N, Cengiz G, Cuzdan N, Albayrak Gezer İ, Keskin D, Mulkoglu C, Resorlu H, Bal A, Duruoz MT, Kucukakkas O, Yurdakul OV, Alkan Melikoglu M, Aydin Y, Ayhan FF, Bodur H, Calis M, Capkin E, Devrimsel G, Ecesoy H, Hizmetli S, Kamanli A, Kutluk O, Sen N, Sendur OF, Tolu S, Toprak M, Tuncer T (2022) Impact of obesity on quality of life, psychological status, and disease activity in psoriatic arthritis: a multicenter study. Rheumatol Int 42:659–668. https://doi.org/10.1007/s00296-021-04971-8

    Article  CAS  PubMed  Google Scholar 

  60. Ballegaard C, Skougaard M, Guldberg-Møller J, Nissen CV, Amris K, Jørgensen TS, Dreyer L, Kristensen LE (2021) Comorbidities, pain and fatigue in psoriatic arthritis, psoriasis and healthy controls: a clinical cohort study. Rheumatology (Oxford) 60:3289–3300. https://doi.org/10.1093/rheumatology/keaa780

    Article  PubMed  Google Scholar 

  61. Klingberg E, Björkman S, Eliasson B, Larsson I, Bilberg A (2020) Weight loss is associated with sustained improvement of disease activity and cardiovascular risk factors in patients with psoriatic arthritis and obesity: a prospective intervention study with two years of follow-up. Arthritis Res Ther 22:254. https://doi.org/10.1186/s13075-020-02350-5

    Article  PubMed  PubMed Central  Google Scholar 

  62. López-Medina C, Molto A, Sieper J, Duruöz T, Kiltz U, Elzorkany B, Hajjaj-Hassouni N, Burgos-Vargas R, Maldonado-Cocco J, Ziade N, Gavali M, Navarro-Compan V, Luo SF, Monti S, Tae-Jong K, Kishimoto M, Pimentel-Santos FM, Gu J, Schiotis R, van Gaalen FA, Geher P, Magrey M, Ibáñez Vodnizza SE, Bautista-Molano W, Maksymowych W, Machado PM, Landewé R, van der Heijde D, Dougados M (2021) Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASAS-PerSpA study. RMD Open 7(1):e001450. https://doi.org/10.1136/rmdopen-2020-001450

  63. Patel P, Rosen CF, Chandran V, Ye YJ, Gladman DD (2018) Addressing comorbidities in psoriatic disease. Rheumatol Int 38:219–227. https://doi.org/10.1007/s00296-017-3895-y

    Article  PubMed  Google Scholar 

  64. Queiro R, Lorenzo A, Pardo E, Brandy A, Coto P, Ballina J (2018) Prevalence and type II diabetes-associated factors in psoriatic arthritis. Clin Rheumatol 37:1059–1064. https://doi.org/10.1007/s10067-018-4042-1

    Article  PubMed  Google Scholar 

  65. Loganathan A, Kamalaraj N, El-Haddad C, Pile K (2021) Systematic review and meta-analysis on prevalence of metabolic syndrome in psoriatic arthritis, rheumatoid arthritis and psoriasis. Int J Rheum Dis 24:1112–1120. https://doi.org/10.1111/1756-185x.14147

    Article  PubMed  Google Scholar 

  66. Rahmatpour Rokni G, Mobini M, Mohammadpour RA, Hoseinian Amiri A, Mohseni A, Bahar A (2018) The association between the components and features of metabolic syndrome in patients with psoriasis and psoriatic arthritis. Iran J Diabetes Obes 10:94–101

    Google Scholar 

  67. Adeodato Ramos LM, Gomes KWP, de Saboia Mont'Alverne AR, Braga MV, Costa Vasconcelos AH, Rodrigues CEM (2021) High prevalence of metabolic syndrome in patients with psoriatic arthritis From northeastern Brazil: association with traditional cardiovascular risk factors and biologic disease-modifying antirheumatic drugs. JCR: J Clin Rheumatol 27(6S):S186-S192. https://doi.org/10.1097/rhu.0000000000001631

  68. Queiro R, Fernández S, Pardo E (2021) Hyperlipidaemia in psoriatic disease: higher prevalence in psoriatic arthritis and inverse association with systemic therapy. Rheumatology (Oxford) 60:3949–3951. https://doi.org/10.1093/rheumatology/keab365

    Article  PubMed  Google Scholar 

  69. Navarro-Millán I, Young SR, Shurbaji S, McDavid C, Cornelius-Schecter A, Johnson B, Cherrington AL, Fraenkel L, Goodman SM, Curtis JR, Venkatachalam S, Safford MM (2020) Barriers and facilitators for screening and treatment of hyperlipidemia among patients with inflammatory arthritis. BMC Rheumatol 4:26. https://doi.org/10.1186/s41927-020-00123-w

    Article  PubMed  PubMed Central  Google Scholar 

  70. Doca AM, Pomirleanu C, Ancuta C (2022) Where borders meet: psoriasic arthritis and the cardiovascular risk. Ro J Rheumatol 31(1). https://doi.org/10.37897/RJR.2022.1.7

  71. Colunga-Pedraza IJ, Galarza-Delgado DA, Azpiri-Lopez JR, Rodriguez-Romero AB, Guajardo-Jauregui N, Cardenas-de la Garza JA, Lugo-Perez S, Meza-Garza A, Loya-Acosta J, Garza-Acosta AC (2021) Nail involvement in psoriatic arthritis patients is an independent risk factor for carotid plaque. Ann Rheum Dis 80:1629–1631. https://doi.org/10.1136/annrheumdis-2021-220782

    Article  CAS  PubMed  Google Scholar 

  72. Bilim S, Içağasioğlu A, Akbal A, Kasapoğlu E, Gürsel S (2021) Assessment of subclinical atherosclerosis with ankle-brachial index in psoriatic arthritis: a case-control study. Arch Rheumatol 36:210–218. https://doi.org/10.46497/archrheumatol.2021.8083

  73. Dalbeni A, Giollo A, Tagetti A, Atanasio S, Orsolini G, Cioffi G, Ognibeni F, Rossini M, Minuz P, Fava C, Viapiana O (2017) Traditional cardiovascular risk factors or inflammation: which factors accelerate atherosclerosis in arthritis patients? Int J Cardiol 236:488–492. https://doi.org/10.1016/j.ijcard.2017.01.072

    Article  CAS  PubMed  Google Scholar 

  74. Ibáñez-Bosch R, Restrepo-Velez J, Medina-Malone M, Garrido-Courel L, Paniagua-Zudaire I, Loza-Cortina E (2017) High prevalence of subclinical atherosclerosis in psoriatic arthritis patients: a study based on carotid ultrasound. Rheumatol Int 37:107–112. https://doi.org/10.1007/s00296-016-3617-x

    Article  CAS  PubMed  Google Scholar 

  75. Luydmila Khimion AB (2019) Interconnection of traditional risk factors with the activity of the inflammatory process and atherosclerosis in patients with psoriatic arthritis. J Clin Med Kaz 1:32–36. https://doi.org/10.23950/1812-2892-JCMK-00663

  76. Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJ, Kvien TK, Dougados M, Radner H, Atzeni F, Primdahl J, Södergren A, Wallberg Jonsson S, van Rompay J, Zabalan C, Pedersen TR, Jacobsson L, de Vlam K, Gonzalez-Gay MA, Semb AG, Kitas GD, Smulders YM, Szekanecz Z, Sattar N, Symmons DP, Nurmohamed MT (2017) EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis 76:17–28. https://doi.org/10.1136/annrheumdis-2016-209775

    Article  CAS  PubMed  Google Scholar 

  77. Gonzalez-Martin C, Grande Morais S, Pertega-Diaz S, Seoane-Pillado T, Balboa-Barreiro V, Veiga-Seijo R (2019) Concordance between the different cardiovascular risk scores in people with rheumatoid arthritis and psoriasis arthritis. Cardiol Res Pract 2019:7689208. https://doi.org/10.1155/2019/7689208

    Article  PubMed  PubMed Central  Google Scholar 

  78. Galarza-Delgado DA, Azpiri-Lopez JR, Colunga-Pedraza IJ, Guajardo-Jauregui N, Rodriguez-Romero AB, Lugo-Perez S, Cardenas-de la Garza JA, Arvizu-Rivera RI, Flores-Alvarado DE, Ilizaliturri-Guerra O, Garcia-Arellano G, Garza-Acosta AC (2022) Cardiovascular risk reclassification according to six cardiovascular risk algorithms and carotid ultrasound in psoriatic arthritis patients. Clin Rheumatol 41:1413–1420. https://doi.org/10.1007/s10067-021-06002-0

    Article  PubMed  Google Scholar 

  79. Martínez-Vidal MP, Andrés M, Jovaní V, Santos-Ramírez C, Romera C, Fernández-Carballido C (2020) Role of carotid ultrasound and systematic coronary risk evaluation charts for the cardiovascular risk stratification of patients with psoriatic arthritis. J Rheumatol 47:682–689. https://doi.org/10.3899/jrheum.181223

    Article  PubMed  Google Scholar 

  80. Martínez-Vidal MP, Fernández-Carballido C (2018) Is the SCORE chart underestimating the real cardiovascular (CV) risk of patients with psoriatic arthritis? Prevalence of subclinical CV disease detected by carotid ultrasound. Joint Bone Spine 85:327–332. https://doi.org/10.1016/j.jbspin.2017.07.002

    Article  PubMed  Google Scholar 

  81. Fragoulis GE, Evangelatos G, Tentolouris N, Fragkiadaki K, Panopoulos S, Konstantonis G, Iliopoulos A, Chatzidionysiou K, Sfikakis PP, Tektonidou MG (2020) Higher depression rad diabetes mellitus. Ther Adv Musculoskelet Dis 12:1759720x20976975. https://doi.org/10.1177/1759720x20976975

Download references

Author information

Authors and Affiliations

  1. Department of Rheumatology, Ümraniye Training and Research Hospital, İstanbul, Turkey

    Halise Hande Gezer

  2. Department of Rheumatology, Kartal Lütfi Kırdar City Hospital, İstanbul, Turkey

    Sevtap Acer Kasman

  3. Rheumatology Division, PMR Department, Marmara University School of Medicine, Istanbul, Turkey

    Mehmet Tuncay Duruöz

Authors
  1. Halise Hande Gezer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sevtap Acer Kasman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mehmet Tuncay Duruöz
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization: Gezer HH, Kasman Acer S, Duruöz MT. Methodology: Gezer HH and Kasman Acer S. Writing—original draft: Gezer HH and Kasman Acer S. Writing—review and editing: Gezer HH, Kasman Acer S, Duruöz MT. All the authors have approved the final manuscript and take full responsibility for the integrity of the contents of the final manuscript.

Corresponding author

Correspondence to Halise Hande Gezer.

Ethics declarations

Disclosures

None.

Disclaimer

No part of the present review, including text, graphics, and ideas, was published or copied from elsewhere.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Part of the Topical Collection entitled ‘Cardiovascular Issues in Rheumatic Diseases’

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gezer, H.H., Acer Kasman, S. & Duruöz, M.T. Autonomic dysfunction and cardiovascular risk in psoriatic arthritis. Clin Rheumatol 42, 2635–2649 (2023). https://doi.org/10.1007/s10067-022-06484-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-022-06484-6

Keywords

Search

Navigation