Skip to main content

Advertisement

Log in

Fetal exposure to canakinumab: a report of three pregnancies

  • Letters of Biomedical and Clinical Research
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Data availability

Not applicable.

Code availability

Not applicable.

References

  1. Berger CT, Recher M, Steiner U, Hauser TM (2009) A patient’s wish: anakinra in pregnancy. Ann Rheum Dis 68:1794–1795

    Article  CAS  Google Scholar 

  2. Fischer-Betz R, Specker C, Schneider M (2011) Successful outcome of two pregnancies in patients with adult-onset Still’s disease treated with IL-1 receptor antagonist (anakinra). Clin Exp Rheumatol 29:1021–1023

    PubMed  Google Scholar 

  3. İlgen U, Küçükşahin O (2017) Anakinra use during pregnancy: report of a case with familial Mediterranean fever and infertility. Eur J Rheumatol 4:66–67

    Article  Google Scholar 

  4. Smith CJF, Chambers CD (2018) Five successful pregnancies with antenatal anakinra exposure. Rheumatology (Oxford) 57:1271–1275

    Article  CAS  Google Scholar 

  5. Chang Z, Spong CY, Jesus AA, Davis MA, Plass N, Stone DL, Chapelle D, Hoffmann P, Kastner DL, Barron K, Goldbach-Mansky RT, Stratton P (2014) Anakinra use during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS). Arthritis Rheumatol 66:3227–3232

    Article  CAS  Google Scholar 

  6. Youngstein T, Hoffmann P, Gül A, Lane T, Williams R, Rowczenio DM, Ozdogan H, Ugurlu S, Ryan J, Harty L, Riminton S, Headley AP, Roesler J, Blank N, Kuemmerle-Deschner JB, Simon A, Woolf AS, Hawkins PN, Lachmann HJ (2017) International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology 56:2102–2108

    Article  Google Scholar 

  7. Gunn JL, Waller R, O’Neil L, David J (2018) Canakinumab use during pregnancy for the treatment of systemic onset juvenile idiopathic arthritis and refractory macrophage activation syndrome. Rheumatology 57(Suppl):3. https://doi.org/10.1093/rheumatology/key075.245

    Article  Google Scholar 

  8. Egawa M, Imai K, Mori M, Miyasaka N, Kubota T (2017) Placental transfer of canakinumab in a patient with Muckle-Wells syndrome. J Clin Immunol 37:339–341

    Article  Google Scholar 

  9. Babaoglu H, Varan O, Kucuk H, Atas N, Satis H, Salman R, Ozturk MA, Goker B, Tufan A, Haznedaroglu S (2020) Effectiveness of canakinumab in colchicine- and anakinra-resistant or -intolerant adult familial Mediterranean fever patients: a single-center real-life study. J Clin Rheumatol 26:7–13

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Conception & design: U.İ., Ş.E.; data acquisition & analysis: U.İ., Ş.E., M.E.Y., O.K.; interpretation: Uİ; manuscript drafting; U.İ., Ş.E., M.E.Y.; critical review: U.İ., Ş.E., M.E.Y., O.K. All authors approve the final version and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Ufuk İlgen.

Ethics declarations

Ethics approval

Not applicable.

Consent to participate

Not applicable.

Consent for publication

Written informed consents were obtained from the patients.

Permissions

Data were reused in Table 1 by permission from Youngstein T et al. International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology 2017; 56: 2102–8. Copyright © 2017, Oxford University Press.

Disclosures

None.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

İlgen, U., Eyüpoğlu, Ş., Yayla, M.E. et al. Fetal exposure to canakinumab: a report of three pregnancies. Clin Rheumatol 41, 1261–1263 (2022). https://doi.org/10.1007/s10067-022-06060-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-022-06060-y

Navigation