Data availability
Supplementary Table 1 is deposited at figshare (https://figshare.com/articles/Supplementary_Table_1/12029283). Script in the current study is available upon request.
References
Clements PJ, Hurwitz EL, Wong WK, Seibold JR, Mayes M, White B, Wigley F, Weisman M, Barr W, Moreland L, Medsger TA, Steen VD, Martin RW, Collier D, Weinstein A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Furst DE (2000) Skin thickness score as a predictor and correlate of outcome in systemic sclerosis: high-dose versus low-dose penicillamine trial. Arthritis Rheum 43:2445–2454
Assassi S, Swindell WR, Wu M, Tan FD, Khanna D, Furst DE, Tashkin DP, Jahan-Tigh RR, Mayes MD, Gudjonsson JE, Chang JT (2015) Dissecting the heterogeneity of skin gene expression patterns in systemic sclerosis. Arthritis Rheumatol 67:3016–3026
Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S (2020) Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile. Ann Rheum Dis 79:379–386
Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559
Mastrogiannaki M, Lichtenberger BM, Reimer A, Collins CA, Driskell RR, Watt FM (2016) β-Catenin stabilization in skin fibroblasts causes fibrotic lesions by preventing adipocyte differentiation of the reticular dermis. J Investig Dermatol 136:1130–1142
Patel CH, Leone RD, Horton MR et al (2019) Targeting metabolism to regulate immune responses in autoimmunity and cancer. Nat Rev Drug Discov 18:669–688
Acknowledgments
Gene expression datasets were obtained from the Prospective Registry for Early Systemic Sclerosis (PRESS) cohort. I thank all investigators for sharing the data.
Author information
Authors and Affiliations
Contributions
All of conceptualization, formal analysis, and writing were conducted by the author.
Corresponding author
Ethics declarations
Disclosures
None.
Ethics approval
Not required because this study uses only publicly available data.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
ESM 1
(XLSX 78 kb)
Rights and permissions
About this article
Cite this article
Inamo, J. Distinct gene network in skin lesion of patients with diffuse cutaneous systemic sclerosis. Clin Rheumatol 39, 3143–3144 (2020). https://doi.org/10.1007/s10067-020-05245-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-020-05245-7