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Dear Sir
Thank you to Rodney Grahame and colleagues for their letter [1], published in this edition, concerning our systematic review of tissue mechanics in hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility syndrome disorders (HSD) [2].
It was very interesting to read that additional measures of ligamentous laxity are being considered in people with hEDS, HSD, and other connective tissue disorders who have suspected craniocervical instability, basilar invagination, or ventral brainstem compression. As highlighted in our review [2], the consensus statements agreed by their group reiterate the potential importance of using measures of soft tissue mechanics that are supplemental to the Beighton score. Their recommendation of dynamic imaging techniques is particularly interesting. We sincerely hope that their group is successful in identifying appropriate diagnostic measures for such cases.
Yours faithfully,
Shea Palmer
Elise Denner
Matthew Riglar
Holly Scannell
Sarah Webb
Georgina Young
References
Grahame R, Malik, Hakim A, Koby M, Henderson F Sr (2020) Comment on “Quantitative measures of tissue mechanics to detect hypermobile Ehlers-Danlos syndrome and hypermobility syndrome disorders: a systematic review”. Clin Rheumatol
Palmer S, Denner E, Riglar M, Scannell H, Webb S, Young G (2020) Quantitative measures of tissue mechanics to detect hypermobile Ehlers-Danlos syndrome and hypermobility syndrome disorders: a systematic review. Clin Rheumatol 39(3):715–725. https://doi.org/10.1007/s10067-020-04939-2
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See related article, https://doi.org/10.1007/s10067-020-05158-5
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Palmer, S., Denner, E., Riglar, M. et al. Response to “Quantitative measures of tissue mechanics to detect hypermobile Ehlers Danlos syndrome and hypermobility syndrome disorders: a systematic review”. Clin Rheumatol 39, 2479 (2020). https://doi.org/10.1007/s10067-020-05192-3
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DOI: https://doi.org/10.1007/s10067-020-05192-3