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Resistin and visfatin: are they valuable enough to be the differential diagnosis in familial Mediterranean fever with acute appendicitis?

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Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disease which predominantly affects certain ethnic groups mainly Sephardic Jews, Turks, Arabs, and Armenians. Differential diagnosis of an attack of FMF with appendicitis could be difficult in patients presenting with acute abdomen. Circulating levels of resistin and visfatin have been shown to increase in several inflammatory conditions. In this study we aimed to investigate the role of resistin and visfatin in diseases activity by monitoring these adipokines’ levels in patients with FMF (attacks and attack-free period) and acute appendicitis. The study involves four groups: group 1—31 FMF patients at attack (M/F, 14/17), group 2—27 FMF patients at attack-free period (M/F, 9/18), group 3—29 acute appendicitis patients (M/F, 16/13), and group 4—20 healthy controls (M/F, 10/10). Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, fibrinogen, resistin, visfatin, interleukin-1β, interleukin-6, interleukin-10, TNF-α, and IFN-γ were evaluated concurrently. Resistin level could be a useful test in diagnosis of FMF patients in attacks period but not in acute appendicitis as differential diagnosis. Measuring visfatin levels would not give additional information neither for attacks and attack-free period nor FMF attack and appendicitis.

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Authors and Affiliations

  1. Department of Internal Medicine Division of Rheumatology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

    Bunyamin Kisacik

  2. Ministry of Health, 4th Surgery Clinic, Ankara Education and Research Hospital, Ankara, Turkey

    Mehmet Fatih Erol

  3. Department of Internal Medicine Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Yuksel Maras, Umut Kalyoncu, Omer Karadag, Sedat Kiraz, Ihsan Ertenli & Meral Calguneri

  4. Ministry of Health, Clinical Biochemistry Laboratory, Ankara Education and Research Hospital, Ankara, Turkey

    Gulsen Yilmaz & Fatma Meric Yilmaz

  5. Gaziantep Universitesi Tip Fakültesi Romatoloji Unitesi, 27100, Şahinbey, Gaziantep, Turkey

    Bunyamin Kisacik

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  1. Bunyamin Kisacik
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  2. Mehmet Fatih Erol
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  3. Gulsen Yilmaz
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  5. Yuksel Maras
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  7. Omer Karadag
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  8. Sedat Kiraz
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  9. Ihsan Ertenli
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  10. Meral Calguneri
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Correspondence to Bunyamin Kisacik.

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Kisacik, B., Erol, M.F., Yilmaz, G. et al. Resistin and visfatin: are they valuable enough to be the differential diagnosis in familial Mediterranean fever with acute appendicitis?. Clin Rheumatol 31, 225–229 (2012). https://doi.org/10.1007/s10067-011-1806-2

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  • DOI: https://doi.org/10.1007/s10067-011-1806-2

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