Abstract
We describe a 32-year-old man who developed granulomatous thyroiditis (GT) during etanercept therapy for rheumatoid arthritis (RA). Fever and thyroid pain developed 8 months after administration of etanercept. Noncaseating epithelioid cell granulomas consistent with GT were detected in a thyroid biopsy. Tissue staining and cultures for bacteria, mycobacterium, and fungus were all negative. Etanercept therapy was withdrawn and steroids regime was indicated with clinical and laboratory improvement. A month after, the patient developed hypothyroidism and recurrence of RA. A year after, the patient is asymptomatic with rituximab, methotrexate, and levothyroxine therapy. We report a case of GT probably in an etanercept-induced granulomatous reaction context.
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Cañas, C.A., Tobón, G.J., Arango, L.G. et al. Developing of granulomatous thyroiditis during etanercept therapy. Clin Rheumatol 28 (Suppl 1), 17–19 (2009). https://doi.org/10.1007/s10067-008-1046-2
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DOI: https://doi.org/10.1007/s10067-008-1046-2