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The association between fibromyalgia and polymorphism of monoamine oxidase A and interleukin-4

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Abstract

Because fibromyalgia (FM) is often comorbid with anxiety, and monoamine oxidase A (MAOA) was reported to be associated with anxiety, we determine if there is MAOA gene polymorphism associated with FM patients. Moreover, interleukin 4 (IL-4) was found to be an important cytokine participating in the immunologic pathway of T-helper 2 (Th-2) cells, in this study, we search if the genetic polymorphism of IL-4 intron3 could be demonstrated in FM patients. The genotype of sixty-two FM patients was compared with that of control subjects. The polymorphism of IL-4 intron3 variable number of tandem repeats (VNTR) was demonstrated by performing the genomic polymerase chain reaction (PCR) and analyzing the length of PCR product. Furthermore, the MAOA 941 G to T polymorphism was also determined by PCR-RFLP (restriction fragment length polymorphism) analysis. The MAOA 941 position genotype polymorphism between FM and control subjects was found neither statistically different in male (p=0.60) or female (p=0.52), nor total allelic frequency (p=0.52). Similarly, the difference of IL-4 intron3 polymorphism between FM and control was neither existing in genotype (p=0.06), nor allele frequency (p=0.07). The result suggests either the genetic linkage between FM and anxiety or that between FM and immunologic diseases are weak. Accordingly, the MAOA 941 position and IL-4 intron3 polymorphisms are not susceptible markers to predict FM.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

    Jonathan Jiunn-Horng Chen

  2. Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan

    Shan-Yu Su

  3. Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan

    Chun-Ming Chen & Fuu-Jen Tsai

  4. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

    Chien-Chen Lai

  5. Internal Medicine Department, China Medical University Hospital, No. 2 Yu-Der Road, North District, Taichung, 404, Taiwan

    Fuu-Jen Tsai

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  1. Shan-Yu Su
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  2. Jonathan Jiunn-Horng Chen
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  3. Chien-Chen Lai
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  4. Chun-Ming Chen
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  5. Fuu-Jen Tsai
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Correspondence to Fuu-Jen Tsai.

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Su, SY., Chen, J.JH., Lai, CC. et al. The association between fibromyalgia and polymorphism of monoamine oxidase A and interleukin-4. Clin Rheumatol 26, 12–16 (2007). https://doi.org/10.1007/s10067-006-0213-6

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  • DOI: https://doi.org/10.1007/s10067-006-0213-6

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