Skip to main content

Advertisement

SpringerLink
Log in

Antiphospholipid and antisynthetase syndrome in a patient with polymyositis–rheumatoid arthritis overlap

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Idiopathic inflammatory myopathies, mainly polymyositis (PM) may occur in the course of several autoimmune diseases. The overlapping forms of myositis, when the patient also meets the criteria for rheumatoid arthritis (RA), affect 3%–5% of myositis patients [1]. To the best of our knowledge this is the first report on the overlapping form of RA, antiphospholipid syndrome (APS) and the serological subgroup of PM, the antisynthetase syndrome (ASS).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Abbreviations

APS:

Antiphospholipid syndrome

ASS:

Antisynthetase syndrome

DVT:

Deep venous thrombosis

GC:

Glucocorticoid

ILD:

Interstitial lung disease

MRI:

Magnetic resonance imaging

PM:

Polymyositis

RA:

Rheumatoid arthritis

RF:

Rheumatoid factor

References

  1. Thymms KE, Weeb J (1985) Dermatomyositis and other connective tissue disease: review of 105 cases. J Rheumatol 12:1140–1148

    PubMed  Google Scholar 

  2. Mathews MB, Bernstein RM (1983) Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity. Nature 304: 177–179

    CAS  PubMed  Google Scholar 

  3. Hughes GRV, Harris EN, Gharavi AE (1986) The anticardiolipin syndrome. J Rheumatol 13:486–489

    CAS  PubMed  Google Scholar 

  4. Love LA, Leff RL, Frase DD et al. (1991) A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogenous patients groups. Medicine (Baltimore) 70:360–374

    Google Scholar 

  5. Miller FW (1993) Myositis-specific autoantibodies. Touchstones for understanding the inflammatory myopathies. JAMA 270:1846–1849

    Article  CAS  PubMed  Google Scholar 

  6. Huemer C, Duesse M, Seerainer W, Lubec G (1995) Juvenile dermatomyositis with major thrombosis – an unusual course. Clin Exp Rheumatol 13:795

    CAS  PubMed  Google Scholar 

  7. Sherer Y, Livneh A, Levy Y, Shoenfeld Y, Langevitz P (2000) Dermatomyositis and polymyositis associated with the antiphospholipid syndrome – a novel overlap syndrome. Lupus 9:42–46

    CAS  PubMed  Google Scholar 

  8. Merkel PA, Chang Y, Pierangeli SS, Covery K, Harris EN, Polisson RP (1996) The prevalence and clinical associations of anticardiolipin antibodies in a large inception cohort of patients with connective tissue diseases. Am J Med 101:576–583

    CAS  PubMed  Google Scholar 

  9. Love PE, Santoro SA (1990) Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and non-SLE disorders. Ann Intern Med 112:682–698

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Clinical Immunology, 3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, 22. Móricz Zs. krt., 4004, Debrecen, Hungary

    Andrea Ponyi & Katalin Dankó

  2. 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary

    Tamás Constantin

Authors
  1. Andrea Ponyi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tamás Constantin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Katalin Dankó
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Katalin Dankó.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ponyi, A., Constantin, T. & Dankó, K. Antiphospholipid and antisynthetase syndrome in a patient with polymyositis–rheumatoid arthritis overlap. Clin Rheumatol 23, 371–372 (2004). https://doi.org/10.1007/s10067-004-0903-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-004-0903-x

Keywords

Search

Navigation