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The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: Molecular target on cancer metabolism

  • Published:
Molecules and Cells

Abstract

1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a polyphenolic compound isolated from Rhus chinensis Mill. PGG has been known to have anti-tumor, anti-angiogenic and anti-diabetic activities. The present study revealed another underlying molecular target of PGG in MDA-MB-231 breast cancer cells by using Illumina Human Ref-8 expression BeadChip assay. Through the Beadstudio v3 micro assay program to compare the identified genes expressed in PGG-treated MDA-MB-231 cells with untreated control, we found several unique genes that are closely associated with pyruvate metabolism, glycolysis/gluconeogenesis and tyrosine metabolism, including PC, ACSS2, ACACA, ACYP2, ALDH3B1, FBP1, PRMT2 and COMT. Consistent with microarray data, real-time RT-PCR confirmed the significant down-regulation of these genes at mRNA level in PGG-treated MDA-MB-231 cells. Our findings suggest the potential of PGG as anticancer agent for breast cancer cells by targeting cancer metabolism genes.

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Authors and Affiliations

  1. Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Korea

    Woo Sik Yu, Soo-Jin Jeong, Ji-Hyun Kim, Hyo-Jung Lee, Hyo Sook Song, Eunjung Ko, Hyo-Jeong Lee, Hyeung-Jin Jang, Young Chul Kim, Hyunsu Bae & Sung-Hoon Kim

  2. College of Dental Medicine, Tufts University, Boston, USA

    Min-Seok Kim

  3. College of Physical Education, Kyung Hee University, Seoul, 130-701, Korea

    Jae-Ho Khil

  4. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

    Chang Yan Chen

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  1. Woo Sik Yu
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Yu, W.S., Jeong, SJ., Kim, JH. et al. The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: Molecular target on cancer metabolism. Mol Cells 32, 123–132 (2011). https://doi.org/10.1007/s10059-011-2254-1

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